Clinical trials: Postoperative Nausea
Osteoarthritis, Knee
Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty
This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of…
- Trial name
- NCT01612702
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Tae Kyun Kim
Postoperative Nausea and Vomiting
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
The objective of the study is to assess the safety and efficacy of two doses of IV palonosetron each administered as a single dose for the prevention of postoperative nausea and vomiting through 72 hours postoperatively in…
- Trial name
- NCT00828295
- Testing
- palonosetron
- Where
- 13 sites in Russia, Ukraine
- Volunteers
- 150 people
- Sponsor
- Helsinn Healthcare SA
Postoperative Vomiting
Effect of Intraoperative Crystalloid Volume on Postoperative Vomiting
Postoperative nausea and vomiting is very common in children undergone tonsillectomy and/or adenoidectomy. The purpose of this clinical trial is to evaluate the antiemetic effect of super-hydration with 0.9% saline in children…
- Trial name
- EICVPV (NCT02177201)
- Testing
- Group 1, Group 2
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Aydin Adnan Menderes University
Gynecological Disease
Optimal Haloperidol Dose for Postoperative Nausea and Vomiting Prevention in High-risk Patients
Low-dose haloperidol is known to be effective for the treatment of postoperative nausea and vomiting (PONV). However, precise dose-response studies have not been completed, especially in patients at high risk for PONV who require…
- Trial name
- NCT01639599
- Testing
- Dexamethasone iv injection, Dexamethasone, haloperidol
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Postoperative Nausea and Vomiting
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
The primary objective of this study is to evaluate the efficacy of a single palonosetron IV dose compared to a single ondansetron IV dose in the prevention of postoperative nausea and vomiting through 24 hours after surgery in…
- Trial name
- NCT01395901
- Testing
- Palonosetron, Ondansetron
- Where
- 44 sites in United States, Argentina and 6 more
- Volunteers
- 670 people
- Sponsor
- Helsinn Healthcare SA
Postoperative Pain, Postoperative Vomiting and Nausea
Efficacy Side-effect Score (ESS): Development and Evaluation of a New Tool for Patients After Surgery
We hypothesized that better control of postoperative pain treatment and its side effects by monitoring ESS might influence the degree of mobility and morbidity in surgical patients and consequently reduce LOS.
- Conditions
- Postoperative Pain, Postoperative Vomiting and Nausea, Postoperative Complications, Mental Status Changes Postoperative
- Trial name
- ESScore (NCT02143128)
- Testing
- Efficacy Safety Score, Verbal Numeric Rating Scale
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Vestre VikenHF Kongsberg Sykehus
Postoperative Nausea and Vomiting, Respiratory Conditions Due to Other External Agents
A Study to Compare Neostigmine vs Sugammadex in Length of PACU Stay in Patients Undergoing Sleeve Gastrectomy Surgery
The investigators will track bariatric patients who received sugammadex versus neostigmine in the post anesthesia care unit until discharge and assess their length of stay and possible nausea / vomiting / hypoxia episodes.
- Trial name
- NCT03276026
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Postoperative Nausea and Vomiting
Olanzapine for Nausea After Surgery
Ambulatory surgery is occurring with rapidly increasing frequency as surgical and anesthetic techniques have improved and pressure to reduce health-care costs has increased.
- Trial name
- NCT02755116
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Jaime B Hyman
Pregnancy Related, Cesarean Delivery
Accupressure of P6 to Reduce Nausea During Cesarean Section
The purpose of this study is to evaluate if the addition of P6 pressure point stimulation as opposed to sham-point stimulation will decrease intraoperative and postoperative nausea and vomiting (IONV and PONV) for patients…
- Conditions
- Pregnancy Related, Cesarean Delivery, Nausea, Vomiting
- Trial name
- NCT04799587
- Testing
- Magnet at P6, Magnet applied to arm not at P6 pressure point.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Nausea and Vomiting, Postoperative
Antiemetic Prophylaxis for Postdischarge Nausea and Vomiting After Hip Arthroscopy
The study is a randomized placebo controlled trial to determine whether repeated postoperative prophylactic ondansetron ("Zofran") administration will prevent postoperative and/or postdischarge nausea and vomiting in patients…
- Trial name
- PDNV (NCT00878228)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Nausea and Vomiting
Study of APD421 as PONV Treatment (Prior Prophylaxis)
Double-blind, randomised, parallel-group, placebo-controlled, adaptive, seamless, dose-selecting study to compare the efficacy of APD421 to placebo as treatment of established PONV, in patients who have had prior PONV prophylaxis.
- Trial name
- NCT02646566
- Testing
- APD421
- Where
- 8 sites in United States, France and 1 more
- Volunteers
- 705 people
- Sponsor
- Acacia Pharma Ltd
Postoperative Nausea and Vomiting
Granisetron Transdermal Patch for Prevention of Postoperative Nausea and Vomiting
The objective of the study is to evaluate the efficacy and safety of adding transdermal preparation of granisetron (Sancuso ®) to the current postoperative nausea and vomiting (PONV) standard prophylaxis regimen with…
- Trial name
- GTPPONV (NCT02457195)
- Testing
- granisetron
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Post-Operative Nausea and Vomiting
A Study to Examine the Safety and Tolerability of MK0517 for the Prevention of Post-Operative Nausea and Vomiting (0517-015)
A new intravenous medication is being tested for the prevention of the nausea and vomiting that occurs after surgery. This new medication is being compared to another intravenous medication that is already available to patients…
- Trial name
- NCT00231777
- Testing
- Comparator: MK0517, Comparator: ondansetron
- Volunteers
- 216 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative, Postoperative Nausea and Vomiting
Effect of Pulmonary Recruitment Maneuver (PRM) on Pain and Nausea After Laparoscopic Bariatric Surgery
The purpose of this prospective, blinded, randomized clinical trial is to investigate whether a ventilator-piloted PRM at the end of laparoscopic bariatric surgery could reduce overall postoperative pain and nausea.
- Trial name
- NCT03026530
- Testing
- Pulmonary recruitment maneuver, Laparoscopic bariatric surgery, Ventilator
- Volunteers
- 200 people
- Sponsor
- Region Östergötland
Thyroidectomy, Thyroid Diseases
Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
The study is to compare the postoperative recovery, as determined by postoperative nausea and vomiting (PONV) after preoperative application of single-dose dexamethasone versus saline in patients undergoing partial or total…
- Trial name
- tPONV (NCT01189292)
- Testing
- Dexamethasone, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 152 people
- Sponsor
- Cantonal Hospital of St. Gallen
Obesity
Prospective, Double Blind, Placebo Control, Bariatric IV Ace
The purpose of this study is to determine if the administration of acetaminophen given intravenously (through an IV) beginning during surgery and then for 3 additional doses during the first 24 hours post-operatively will reduce…
- Trial name
- Bariatricace (NCT02452320)
- Testing
- intravenous acetaminophen
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Weill Medical College of Cornell University
Tonsillitis
Battlefield Auricular Acupuncture During Adult Tonsillectomies and Effect of Post op Pain and Nausea
The purpose of this study is to determine if auricular acupuncture significantly reduces post-operative pain in comparison to the standard of care.
- Trial name
- BFA (NCT02571075)
- Testing
- Auricular acupuncture
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
PONV
Efficacy of IV Palo With IV Dexamethasone vs IV Palo for Prevention of Immediate & Delayed PONV
The purpose of this study is to determine if subjects who receive Palonosetron plus Dexamethasone have less post-operative nausea and vomiting (PONV) than those who receive Palonosetron alone.
- Trial name
- PONV (NCT00952133)
- Testing
- Palonosetron only, Palonosetron with Dexamethasone
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- NYU Langone Health
Postoperative Nausea
How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women
This is called "Aim 1" of the investigators' NIH grant. Ondansetron (Zofran) is a safe and effective drug used in pregnant women to prevent nausea but the investigators do not know what effect pregnancy may have on the metabolism…
- Trial name
- Zofran_PK (NCT01801475)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Post-operative Nausea, Post-operative Vomiting
Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery
The purpose of this study is to determine whether a multi-modal anesthesia and pain control protocol reduces post-operative and post-discharge nausea and vomiting (PONV and PDNV) in patients undergoing upper jaw corrective…
- Conditions
- Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
- Trial name
- NCT01592708
- Testing
- Antiemetic anesthesia protocol
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of North Carolina, Chapel Hill