Clinical trials: Postoperative Nausea and Vomiting, active
PONV
Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study is a randomized controlled clinical trial focusing on the prevention of postoperative nausea and vomiting (PONV), planned to start in May 2026 and end in April 2027.
- Trial name
- NCT07891312
- Testing
- Amisulpride, Ondansetron
- Volunteers
- 718 people
- Sponsor
- Qianfoshan Hospital
Laparoscopic Cholecystectomy
Binaural Beats and Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy
This research is a single-center, parallel-group, single-blind, randomized controlled experimental study planned to evaluate the effect of postoperative binaural beats (BB) application on the incidence of postoperative nausea and…
- Trial name
- NCT07879274
- Testing
- Binaural Beats Application
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Bitlis Eren University
Postoperative Nausea, Postoperative Vomiting
Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial
The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult…
- Trial name
- ASPIRE-PONV (NCT07152249)
- Testing
- AW-D Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 19,480 people
- Sponsor
- Vanderbilt University Medical Center
Cholelithiasis, Postoperative Nausea and Vomiting
A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy
This study is designed to compare three sedative medications used during general anesthesia for gallbladder removal surgery (laparoscopic cholecystectomy) and their effects on nausea and vomiting after surgery.
- Trial name
- NCT07758803
- Testing
- Propofol, Ciprofol, Remimazolam
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Xi'an Aerospace General Hospital
Postoperative Vomiting, Postoperative Nausea and Vomiting
Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery
Pediatric strabismus surgery is frequently followed by postoperative nausea and vomiting, which can cause significant discomfort, dehydration, and delayed recovery in young children.
- Conditions
- Postoperative Vomiting, Postoperative Nausea and Vomiting, Strabismus
- Trial name
- NCT07871292
- Testing
- Ketamine and Propofol, Sevoflurane
- Volunteers
- 50 people
- Sponsor
- Assiut University
Adolescent Idiopathic Scoliosis, Postoperative Pain, Acute
The Use of a Comfort Tote to Improve Recovery in Pediatric and Adolescent Patients After Surgery
The goal of this clinical trial is to learn if the use of Comfort Tote can treat pain and anxiety in adolescents with idiopathic scoliosis undergoing posterior spinal fusion. The study aims to answer two questions: 1.
- Conditions
- Adolescent Idiopathic Scoliosis, Postoperative Pain, Acute, Postoperative Nausea and Vomiting, Anxiety
- Trial name
- NCT07632833
- Testing
- The Therapeutic Comfort Tote, The Modified Comfort Tote
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV)
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV), Postoperative Nausea and Vomiting
- Trial name
- NCT07868861
- Testing
- NS003 Ondansetron HCl microspheres powder for nasal application, Ondansetron Solution for IV infusion 8mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting
The Effect of White and Pink Noise in Patients Undergoing Total Hip and Knee Arthroplasty
This study aims to investigate the effects of preoperative white noise and pink noise interventions on sleep quality, anxiety, postoperative pain, nausea, and physiological parameters in patients undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting, Anxiety, Postoperative Pain After Arthroscopic Knee Surgery
- Trial name
- NCT07858058
- Testing
- White Noise Intervention, Pink Noise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people
- Sponsor
- Ataturk University
Postoperative Nausea and Vomiting
Effects of taVNS Combined With Dexmedetomidine on POVN
To explore the effects and possible mechanisms of dexmedetomidine combined with taVNS on the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic surgery
- Trial name
- NCT07271147
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator, Dexmedetomidine
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Affiliated Hospital of Nantong University
Chronic Sinusitis, Postoperative Pain
Opioid-Free Anesthesia in FESS: A Prospective ERAS Study
1. Information for Patients and Families What is this study about? When patients undergo functional endoscopic sinus surgery (FESS), strong pain relievers called opioids are traditionally used during anesthesia.
- Conditions
- Chronic Sinusitis, Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Surgical Field Visibility
- Trial name
- OFA-FESS (NCT07812389)
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Filiz Kaya
Post Operative Nausea and Vomiting (PONV)
Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery
Amisulpride is a potent antagonist of dopamine D2 and D3 receptors, both implicated in the emetic response when activated. It is currently used intravenously for the prevention of chemotherapy-induced and postoperative nausea and…
- Trial name
- NCT06887621
- Testing
- Encapsulated amisulpride 50 mg (matched for color, weight, smell and size)
- Where
- Brazil
- Volunteers
- 276 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
PONV
Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.
The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.
- Trial name
- NCT07806162
- Testing
- Opioid Free Anaesthesia, conventential opioid-based anaesthesia (OBA,
- Volunteers
- 120 people
- Sponsor
- Sohag University
Postoperative Nausea and Vomiting
Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy
The goal of this superiority randomized controlled trial (RCT) is to learn if one dual-drug arm increases patient comfort (time to needing rescue medication for nausea/vomiting) more effectively than the other in adults with…
- Trial name
- NCT07638527
- Testing
- ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg
- Where
- Pakistan
- Volunteers
- 264 people
- Sponsor
- Faisalabad Medical University
Postoperative Nausea and Vomiting, Postoperative Pain
Postoperative Nausea, Vomiting and Pain After Bariatric Surgery - a National Registry Study
Around 4,000-5,000 bariatric (weight-loss) operations are performed in Sweden every year. Nausea, vomiting and pain are common immediately after these operations, cause considerable suffering and increase the intensity and length…
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Obesity, Morbid, Bariatric Surgery
- Trial name
- BAROSPOR (NCT07797374)
- Where
- 2 sites in Sweden
- Volunteers
- 30,000 people
- Sponsor
- Umeå University
Remote Monitoring of Pain and Recovery Quality in the Immediate Postoperative Period Using a Digital Health Tool, Pain, Postoperative
Remote Assessment of Pain and Recovery Quality After Surgery Using a Digital Form: A Pilot Study
After surgery, doctors need to know how patients are doing, especially in the first hours after they leave the recovery room. This can be hard to track once patients go to a regular hospital room, and some symptoms - like pain or…
- Conditions
- Remote Monitoring of Pain and Recovery Quality in the Immediate Postoperative Period Using a Digital Health Tool, Pain, Postoperative, Postoperative Nausea and Vomiting, Recovery of Function (G11.427.698.620)
- Trial name
- NCT07794267
- Testing
- Digital web-based postoperative follow-up form
- Where
- Brazil
- Volunteers
- 213 people
- Sponsor
- Hospital de Base
Prevention of Postoperative Nausea and Vomiting
A Clinical Trial of HRS5580 for Injection Combined With Palonosetron Hydrochloride for the Prevention of Postoperative Nausea and Vomiting
The study is being conducted to evaluate the efficacy of HRS5580 for injection combined with palonosetron hydrochloride in the prevention of postoperative nausea and vomiting, and to explore the effective dose of HRS5580 for…
- Trial name
- NCT07709897
- Testing
- HRS5580 for injection combined with palonosetron hydrochloride;, HRS5580 for injection combined with palonosetron hydrochloride, HRS5580 for injection blank preparation combined with palonosetron hydrochloride
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Postoperative Nausea and Vomiting
Effect of a Multimodal Antiemetic Protocol on Postoperative Nausea and Vomiting in Patients Undergoing Flap Surgery for Head and Neck Cancer
This prospective randomized controlled trial evaluates whether a multimodal antiemetic protocol can reduce postoperative nausea and vomiting (PONV) in patients undergoing flap surgery for head and neck cancer.
- Trial name
- NCT07786155
- Testing
- Standard antiemetic and anesthetic protocol, Multimodal antiemetic and anesthetic protocol
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Postoperative Sleep Quality, Postoperative Behaviour
Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)
Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record.
- Conditions
- Postoperative Sleep Quality, Postoperative Behaviour, Postoperative Recovery in Children, Postoperative Nausea and Vomiting (PONV)
- Trial name
- SCORPION (NCT07777276)
- Testing
- Dexamethasone (IV), Ondansetron iv
- Where
- 3 sites in Australia, Brazil
- Volunteers
- 500 people
- Sponsor
- Telethon Kids Institute
Postoperative Nausea and Vomiting, Postoperative Complications
Early PONV - a Registry Based Study in Sweden.
The study is an registry study based on data from the Swedish Perioperative Registry (SPOR) during the years 2016-2022 with the aim to explore the risk for postoperative nausea and vomiting at the recovery unit (early PONV).
- Trial name
- SPOR-PONV (NCT04433676)
- Testing
- no intervention
- Where
- Sweden
- Volunteers
- 1,500,000 people
- Sponsor
- Jakob Wallden
Emergence Delirium
MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children
Postoperative agitation and emergence delirium describe a spectrum of symptoms of early postoperative negative behavior, in which the child experiences a variety of behavioral disturbances including crying, thrashing, and…
- Trial name
- MELA-PAED (NCT05541276)
- Testing
- Melatonin, Isotonic sodium chloride solution
- Where
- Denmark
- Volunteers
- 676 people
- Sponsor
- Arash Afshari