Clinical trials: Postoperative Neuromuscular Block
Neuromuscular Blockade
Deep Neuromuscular Blockade on Postoperative Pain
This study aims to investigate the impact of varying degrees of neuromuscular blockade on postoperative pain in pediatric patients aged over 2 months to under 7 years undergoing laparoscopic surgery under general anesthesia.
- Trial name
- NCT06679569
- Testing
- rocuronium 0.2 mg/kg/hr continuous infusion, rocuronium 0.6 mg/kg/hr continuous infusion
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Seoul National University Hospital
Pain, Postoperative, Muscle Weakness
Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty
The goal of this clinical trial is to compare two regimens of the pericapsular nerve group (PENG) block, an ultrasound-guided injection of local anaesthetic targeting the nerves supplying the front of the hip joint, for…
- Conditions
- Pain, Postoperative, Muscle Weakness, Arthroplasty, Replacement, Hip
- Trial name
- NCT07855341
- Testing
- Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Neuromuscular Blockade, Innate Inflammatory Response
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
- Conditions
- Neuromuscular Blockade, Innate Inflammatory Response, Quality of Life, Postoperative Complications
- Trial name
- HIPPO (NCT05562999)
- Testing
- Rocuronium Bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Reversal of Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis
The purpose of this study was to demonstrate in patients with myasthenia gravis (MG) undergoing thoracoscopic thymectomy faster recovery from a moderate neuromuscular block induced by rocuronium after reversal at reappearance of…
- Trial name
- NCT06436768
- Testing
- Sugammadex, Neostigmine
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Beijing Tongren Hospital
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Cesarean Section, Pain, Postoperative
Regional Analgesia After Cesarean Section
All patients will be anaesthetized with spinal technique. Each patient will be treated with intravenous morphine - patient controlled analgesia (PCA).
- Conditions
- Cesarean Section, Pain, Postoperative, Pain, Neuropathic
- Trial name
- NCT03244540
- Testing
- TAP (transversus abdominis plane block), QLB (quadratus lumborum block), Stimuplex Ultra 360 needle
- Where
- 2 sites in Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Lublin
Neuromuscular Blockade, Neuromuscular Blockade, Residual
Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade
The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four…
- Trial name
- NCT05037006
- Testing
- Sevoflurane - Neostigmine 30, Sevoflurane - Neostigmine 50, Sevoflurane - Neostigmine 70
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Local Anesthetic Complication, Local Anesthetic Drug Adverse Reaction
Defining Normal Postoperative Magnetic Resonance Imaging After Total Knee Arthroplasty
The aim of this study was to describe the postoperative "baseline" magnetic resonance imaging (MRI) appearance of the ipsilateral thigh musculature after total knee arthroplasty (TKA).
- Trial name
- NCT04821245
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Benaroya Research Institute
Neuromuscular Block, Residual
Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery
The purpose of this study is to assess the effect of quantitative block monitoring versus less expensive qualitative monitoring treatment effects on the lowest SpO2/FiO2 ratio in the PACU.
- Trial name
- QUANTUM (NCT07084363)
- Testing
- Quantitative monitoring, Qualitative monitoring
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- The University of Texas Health Science Center, Houston
Residual Neuromuscular Blockade, Curarization, Postoperative Residual
Validation of the REPS Prediction Tool
Neuromuscular blocking agents' (NMBA) use during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Residual Neuromuscular Blockade, Curarization, Postoperative Residual, Postoperative Respiratory Complication
- Trial name
- NCT03585400
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 101,510 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Neuromuscular Blockade
Reducing the Incidence of PostOperative Residual Curarization
The NMB (Neuromuscular Blockade) is the most frequent complication in anesthesiology associated with an increase in adverse respiratory events in the postoperative period. Its appearance depends on multiple factors.
- Trial name
- PORCzero (NCT03128151)
- Testing
- Educational program for clinicians: implementation of a package of clinical prevention measures of NMB
- Where
- Spain
- Volunteers
- 2,314 people
- Sponsor
- Oscar Diaz-Cambronero
Anesthesia, Neuromuscular Blockade
Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants
Although tonsillectomy is one of the most commonly performed surgeries, a review of literature reveals no articles dealing with the study of intraoperative blood loss in tonsillectomy and adenotonsillectomy according to the use…
- Conditions
- Anesthesia, Neuromuscular Blockade, Intraoperative Bleeding, Intraoperative Blood Loss
- Trial name
- NCT06399445
- Testing
- conventional cold tonsillectomy and curettage adenoidectomy, Rocuronium Bromide
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital of Split
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery, Immune Suppression
- Trial name
- RECOVER-PLUS (NCT03572413)
- Testing
- Low pressure pneumoperitoneum, Rocuronium bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Neuromuscular Blockade
Residual Block in Postoperative Anaesthetic Care Unit
The purpose of this study is to assess the incidence of residual block in patients arriving in the Post Anaesthetic Care Unit (PACU) following surgery, and in those who have received neuromuscular blocking drugs (muscle…
- Trial name
- NCT02930629
- Testing
- Train-of-Four (TOF) Watch
- Where
- Singapore
- Volunteers
- 400 people
- Sponsor
- Singapore General Hospital
Curarization, Postoperative Residual
A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old
Sugammadex is a drug used more and more frequently in infants as a rocuronium' s reversal agent. It has multiples benefits over other reversal agents such as a rapid onset of action and a complete reversal no matter how deep is…
- Trial name
- SUGAPEDIA (NCT07477132)
- Testing
- Sugammadex
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Caen
Blood Coagulation Tests ( INR, APTT)
Sugammadex Reversal of Neuromuscular Blockade and Postoperative Bleeding
Sugammadex is new drug that is used for reversal of rocuronium induced muscle relaxation. benefits of reversal of neuromuscular blockade appears to be of great value in living donor liver transplant recipients.
- Trial name
- Suga_bleeding (NCT02939430)
- Testing
- Sugammadex intravenous, Intravenous neostigmine and atropine
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Breast Cancer, Postoperative Pain, Acute
Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. RIB has been reported to be successful in attenuating acute pain following breast surgeries.
- Conditions
- Breast Cancer, Postoperative Pain, Acute, Postoperative Pain, Chronic, Neuropathic Pain
- Trial name
- NCT06019325
- Testing
- RIB
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Muğla Sıtkı Koçman University
Stomach Cancer
The Effect of Deep Neuromuscular Block on the Perioperative Stress Response Reduction and Postoperative Recovery Enhancement in Robot-assisted Stomach Cancer Surgery
Stress reactions caused by surgical stimuli can cause sympathetic nervous system activation and increased stress hormones, such as catecholamines, inflammatory cytokines, and pituitary hormones, and insulin resistance.
- Trial name
- NCT03937440
- Testing
- Deep neuromuscular block with 'rocunium®', Moderate neuromuscular block with 'rocunium®'
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Residual Neuromuscular Blockade in Elderly Patients
The Effect of Age on the Incidence of Postoperative Residual Neuromuscular Blockade
Residual neuromuscular blockade is frequently observed in the early postoperative period when patients have received a general anesthetic with muscle relaxants.
- Trial name
- NCT01545193
- Testing
- Age and incidence of residual neuromuscular blockade
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Endeavor Health