Clinical trials: Postoperative Ocular Pain
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Topical Anaesthesia, General Anesthetic Drug Adverse Reaction
Evaluation of Postoperative Pain in Cases Undergoing Cataract Surgery Under Topical Versus General Anesthesia
Comparison between cataract surgery under local versus general anesthesia regarding postoperative pain, complications and patient satisfaction and need for rescue analgesic intake after surgery The results will be followed up at…
- Conditions
- Topical Anaesthesia, General Anesthetic Drug Adverse Reaction, Cataract
- Trial name
- NCT07287683
- Testing
- Topical Anaesthesia group, General Anaesthesia group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Myopia
Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain
Compare the use of codeine/paracetamol against placebo for pain control after cornea photorefractive keratectomy (PRK).
- Trial name
- NCT02625753
- Testing
- Codeine, paracetamol
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Pterygium, Preoperative Anxiety
Video-Assisted Patient Education and Eye Fixation Training in Pterygium Surgery
This randomized controlled trial aims to investigate the effects of preoperative video-assisted patient education combined with eye position fixation training on anxiety, pain, intraoperative compliance, operation duration, and…
- Conditions
- Pterygium, Preoperative Anxiety, Postoperative Pain
- Trial name
- NCT07858045
- Testing
- Video-Assisted Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people
- Sponsor
- Ataturk University
Ocular Infections, Irritations and Inflammations
Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation
The primary purpose of this study is to determine the efficacy and safety of KPI-121 ophthalmic suspension compared to placebo in subjects who have undergone cataract surgery.
- Trial name
- Hawaii-1 (NCT02163824)
- Testing
- KPI-121 0.25%, KPI-121 1.0%, Vehicle of KPI-121 0.25%
- Where
- 23 sites in United States
- Volunteers
- 380 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Strabismus
Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery
The purpose of this study is to determine if local anesthetic, either a subtenons injection (an injection just beneath the surface tissue of the eye) or a topical ophthalmic gel (applied directly on the surface of the eye) given…
- Trial name
- NCT01812044
- Testing
- subtenons anesthetic - preservative-free bupivacaine 0.75%, topical anesthetic - 0.5 cc of lidocaine 3.5% ophthalmic gel, topical control - 0.5 cc of Hypromellose 0.3% gel
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Retinal Detachment
REtinal Detachment Outcomes Study
Background: Few large randomized controlled trials provide strong evidence to guide surgical repair of primary rhegmatogenous retinal detachment (RRD) repair.
- Trial name
- REDOS (NCT05863312)
- Testing
- Pars plana vitrectomy, Pars plana vitrectomy with scleral buckle, Sulfur hexafluoride gas tamponade
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- CHU de Quebec-Universite Laval
Blepharoptosis
Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid
Conjunctival Mullerectomy is a well known procedure used to correct upper lid ptosis via a posterior approach. Patients who undergo this procedure are often given local anesthesia to alleviate intraoperative and postoperative…
- Trial name
- NCT01350024
- Testing
- Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Wound Heal, Oral Dryness
Assessing the Efficacy of a Carbamide Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia Relief
The aim of this study is to evaluate the efficacy and safety of a carbamide peroxide mouthwash regarding oral wound healing, postoperative symptoms, xerostomia (dry mouth) and oral hygiene improvement.
- Conditions
- Wound Heal, Oral Dryness, Postoperative Pain, Sjogren's Syndrome
- Trial name
- NCT06363955
- Testing
- Carbamide Peroxide Mouthwash
- Where
- Greece
- Volunteers
- 54 people
- Sponsor
- National and Kapodistrian University of Athens
Sleep Deprivation, Postoperative Pain
The Effect of Night Eye Mask on Post-operative Pain in Cardiac Surgery Patients
Environmental factors such as noise and light have been cited as important causes of sleep deprivation in Intensive care unit (ICU) patients.
- Trial name
- NCT03213860
- Testing
- Flight Eye-masks; Dreaming, Zhuji City, Zhejiang, China
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Inflammation Eye Pain, Postoperative Cataract
A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
This was a randomized, double-masked, vehicle-controlled, Phase 3 study evaluating the efficacy and safety of OCS-01 QD compared to vehicle in the treatment of inflammation and pain following cataract surgery.
- Trial name
- OPTIMIZE-1 (NCT05147233)
- Testing
- OCS-01, Vehicle
- Where
- 25 sites in United States
- Volunteers
- 241 people
- Sponsor
- Oculis
Choroidal Melanoma, Melanoma
Pain Relief - Tramadol Versus Ibuprofen
The purpose of this study is to assess post operative pain following the insertion of radioactive plaque for choroidal melanoma in patients after receiving either ibuprofen or tramadol.
- Conditions
- Choroidal Melanoma, Melanoma, Eye Neoplasms
- Trial name
- NCT00111046
- Testing
- Ibuprofen, Tramadol
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Liverpool University Hospital
Corneal Epithelial Wound Healing, Post Operative Pain
Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking.
- Trial name
- NCT07812129
- Testing
- Insulin eye drops, standard post-operative topical drops
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Postoperative Pain, Analgesia
Application of Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Under Laparoscopic Direct Vision in Laparoscopic Renal Surgery
Evaluation of the effectiveness of Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision compared to local infiltration anesthesia for postoperative analgesia after laparoscopic…
- Conditions
- Postoperative Pain, Analgesia, Quadratus Lumborum Block, Laparoscopic Renal Surgery
- Trial name
- NCT06550869
- Testing
- Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision, Local infiltration anesthesia
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pterygium of Both Eyes
Dextenza for Post-operative Treatment of Pterygium
DEXTENZA for the Treatment of Post-Surgical Pain and Inflammation Compared to Standard of Care Topical Cortico-steroid Treatment in Patients who Undergo Bilateral Pterygium Surgery
- Trial name
- PERSIST (NCT04351737)
- Testing
- Intracanalicular Dexamethasone, (0.4 mg) Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brandon Eye Associates, PA
CABG, Physiological Parameter
The Effect of Virtual Reality and Eye Mask During Dressing After CABG Surgery
This study aims to evaluate the effects of virtual reality (VR) and eye mask (EM) applications on pain, anxiety, and physiological parameters during dressing after Coronary Artery Bypass Graft (CABG) surgery.
- Conditions
- CABG, Physiological Parameter, Postoperative Pain, Postoperative Anxiety
- Trial name
- CABG (NCT07039812)
- Testing
- Virtual Reality Headset, Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University - Cerrahpasa
Corneal Endothelial Cell Loss, Ocular Pain
RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD
This study assesses the efficacy and safety of two concentrations of omaveloxolone (RTA 408) ophthalmic suspension for the prevention of corneal endothelial cell loss following cataract surgery.
- Conditions
- Corneal Endothelial Cell Loss, Ocular Pain, Ocular Inflammation, Cataract Surgery
- Trial name
- NCT02128113
- Testing
- Vehicle Ophthalmic Solution, Omaveloxolone Ophthalmic Suspension 0.5%, Omaveloxolone Ophthalmic Suspension 1%
- Where
- 15 sites in United States
- Volunteers
- 307 people
- Sponsor
- Biogen
Postoperative Pain
Postoperative Pain in Orbital Disease and Ocular Tumor
The purpose of this study is to evaluate the postoperative pain after general anesthesia of orbital diseases and ocular tumor patients.
- Trial name
- NCT02704715
- Testing
- general anesthesia,orbital operation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Myopia
Preservative-free Topical Anesthetics for Post-PRK Pain
The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step…
- Trial name
- NCT05733741
- Testing
- Preservative-free Benoxinate hydrochloride 0.4% (Benoxidia unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt), Preservative-free Sodium hyaluronate 0.2% (Polyfresh unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt).
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University