Clinical trials: Postoperative Pain, Chronic
Thyroid Cancer, Goiter
Superficial Cervical Plexus Block With Dexmedetomidine Versus Without Adjuvant in Thyroid Surgery
Efficacy of Superficial Cervical Plexus Block (SCPB) with Dexmedetomidine Adjuvant Compared to Without Adjuvant in Thyroid Surgery.
- Conditions
- Thyroid Cancer, Goiter, Hyperthyroidism
- Trial name
- BPSS-DEX (NCT07274670)
- Testing
- Dexmedetomidine & Bupivacaine., Bupivacain
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- Udayana University
Failed Back Surgery Syndrome, Lumbar Radiculopathy
EuroPainClinicsStudy IX ( EPCS IX )
This prospective investigator-initiated study compares the clinical effectiveness and safety of epiduroscopic adhesiolysis in patients with failed back surgery syndrome (FBSS) and in patients with lumbar radicular pain without…
- Conditions
- Failed Back Surgery Syndrome, Lumbar Radiculopathy, Chronic Low Back Pain, Epidural Fibrosis
- Trial name
- EPCS IX (NCT07411950)
- Testing
- Epiduroscopic mechanical adhesiolysis, Epidural pharmacologic therapy
- Where
- Slovakia
- Volunteers
- 141 people
- Sponsor
- EPC Education s.r.o.
Mastectomy
Biological and Clinical Underpinnings of Postoperative Pain - Mastectomy
Persistent pain after mastectomy remains a significant clinical challenge that can delay recovery, reduce quality of life, and increase long-term healthcare burden.
- Trial name
- BAC-UPP 1 (NCT07271589)
- Volunteers
- 86 people
- Sponsor
- University of Alabama at Birmingham
Postsurgical Pain, Cesarean Section
Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section
Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and…
- Conditions
- Postsurgical Pain, Cesarean Section, Chronic Post-surgical Pain
- Trial name
- NCT06344169
- Testing
- Sebacoyl Dinalbuphine Ester, Morphine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Dalin Tzu Chi General Hospital
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Pain, Postoperative
Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgeries (VATS) include severe postoperative acute pain which is also a predictor of chronic pain.
- Trial name
- VATS (NCT02302586)
- Testing
- Thoracic paravertebral block (TPVB), Patient Controlled Analgesia (IV PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Pain, Chronic Pain
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
The purpose of this trial is to investigate the efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain in comparison to placebo plaster.
- Conditions
- Pain, Chronic Pain, Neuropathic Pain, Postoperative Pain
- Trial name
- NCT01752322
- Testing
- Lidocaine 5% medicated plaster
- Where
- 42 sites in Austria, Belgium and 6 more
- Volunteers
- 444 people
- Sponsor
- Grünenthal GmbH
Failed Back Surgery Syndrome
A Post Market Study on DRG Stimulation in FBSS (SYMPATHY)
The purpose of this Post Market Observational Study is to monitor the effect of the Axium® SCS System in the management of chronic pain following surgical lumbar discectomy in subjects whom are routinely scheduled for treatment…
- Trial name
- NCT02634398
- Where
- Switzerland
- Sponsor
- Abbott Medical Devices
Cryotherapy Effect, Chronic Pain
Intercostal Cryoanalgesia for Chronic Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Cryotherapy Effect, Chronic Pain, Lung Cancer, Surgery
- Trial name
- CRYO-VATS-2 (NCT05884099)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Chronic Pain
Preventing Chronic Post Surgical Pain After Limb Surgery
This is a non-randomized prospective study. Patients undergoing upper extremity and shoulder surgical procedures after trauma at SJHC and LHSC will be divided in to two groups.
- Trial name
- PCPSPAULS (NCT02630498)
- Testing
- Brachial plexus block
- Where
- 2 sites in Canada
- Volunteers
- 55 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Pain
Susceptibility to Chronic Post-Traumatic Extremity Pain
The association between the COMT haplotypes and the presence or absence of CPSP or CRPS will be assessed stratifying the patients based on the individual categories of trauma or elective surgery.
- Trial name
- NCT00672711
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Corewell Health East
Persistent Post-surgical Pain, Neuropathic Pain
Development of a Personalised Care Plan Designed to Reduce Chronic Post-Operative Pain Following Breast Surgery
Numerous surveys have shown that following breast surgery, longterm pain affects around half of patients. Given that 1 in 9 women will get breast cancer and that surgery is the cornerstone of treatment, persistent pain represents…
- Conditions
- Persistent Post-surgical Pain, Neuropathic Pain, Cancer Pain
- Trial name
- NCT02170415
- Testing
- Protective analgesia, Pain education, Psychological support
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Vaginal Hysterectomy, Suburethral Slings
Sedation With Dexmedetomidine Versus Remifentanil in Urogynecological Surgery Under Spinal Anaesthesia
Neuraxial blocks are usually used as an anaesthetic method for urogynecological surgeries. In most patients under regional anaesthesia, premedication is given for reducing anxiety.
- Trial name
- NCT03883347
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Athens
Pain, Phantom, Pain, Neuropathic
Valproic Acid for the Prevention of Post-Amputation Pain
The objectives of this study are, to test the effectiveness of Valproic Acid (VPA) in the prevention of chronic neuropathic and post-amputation pain, as well as to further define the underlying inflammatory and epigenetic…
- Trial name
- NCT01928849
- Testing
- Valproic Acid, Cherry Syrup
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Acute Pain, Chronic Pain
The Effects of TAP Block on Postsurgical Pain After Minimally Invasive Partial Nephrectomy:
Single-center study in order to assess whether the tap block can make extremely beneficial in terms of reducing the acute and chronic pain as well as for use of opioids and side effects related to it in patients undergoing…
- Trial name
- NCT02460640
- Testing
- Tap block, intravenous Patient controlled analgesia, Morphine
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Regina Elena Cancer Institute
Phantom Limb Pain, Chronic Pain
Prevention of Phantom Limb Pain After Transtibial Amputation
Phantom limb pain following amputation is a major problem. Current evidence how to best prevent phantom limb pain is equivocal because previous trials have included small numbers of patients, and tested heterogeneous patient…
- Conditions
- Phantom Limb Pain, Chronic Pain, Prevention
- Trial name
- PLATA (NCT01626755)
- Testing
- Sciatic name block
- Where
- 9 sites in United States, Austria and 3 more
- Volunteers
- 12 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Postsurgical Pain, Acute Post Operative Pain
Prediction of Chronic Postsurgical Pain in Adults
This research will be a prospective single-centre observational cohort study in Denmark spanning approximately one year. The objective of this study is to develop a clinically applicable and generalizable prediction model for…
- Trial name
- NCT04866147
- Testing
- Cardiothoracic surgery, Breast surgery, Gastrointestinal surgery
- Where
- 2 sites in Denmark
- Volunteers
- 1,522 people
- Sponsor
- University of Aarhus
Rebound Pain, Total Knee Arthroplasty
Heart Rate Variability as a Predictor of Rebound Pain Following Total Knee Arthroplasty
This study aims to investigate whether heart rate variability (HRV), a marker of autonomic nervous system activity, can predict the occurrence of rebound pain after total knee arthroplasty (TKA).
- Conditions
- Rebound Pain, Total Knee Arthroplasty, Postoperative Pain, Chronic, Heart Rate Variability
- Trial name
- NCT06977191
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Konya City Hospital
Thoracic Surgery, Chronic Pain
Transcranial Magnetic Stimulation (TMS) for Thoracic Surgery
Patients with high severity of post-surgical pain scores will be randomized to transcranial magnetic stimulation (TMS) vs sham TMS groups. Both group of patients will have 10 TMS sessions during 5 days.
- Conditions
- Thoracic Surgery, Chronic Pain, Transcranial Magnetic Stimulation, Neuromodulation
- Trial name
- NCT03994991
- Testing
- active TMS
- Where
- United States
- Sponsor
- Emine Bayman
Post Operative Pain, Chronic Pain
Performance and Safety of the ANTALGEEK® Thess Monitoring Medical Device in the Outpatient Management of Acute Pain and Postoperative Recovery
Acute postoperative pain (APOP) is a major public health problem, affecting nearly 10 million patients in France each year. Effective analgesic therapy in the first postoperative week is a key factor in reducing early…
- Trial name
- TRACE (NCT07680998)
- Testing
- Post-operative follow-up using the Thess Telemonitoring device in conjunction with the ANTALGEEK® protocol
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes