Clinical trials: Postoperative Pancreatic Fistula
Postoperative Pancreatic Fistula Post-pancreatoduodenectomy
Evaluation of the Perfusion of the Pancreatic Remnant With Indocyanine Green and Its Impact on the Reduction of Pancreatic Fistula After Pancreaticoduodenectomy
Postoperative pancreatic fistula (POPF) is the most common complication following cephalic duodenopancreatectomy (DPC) and is a key determinant of severe postoperative morbidity and mortality.
- Trial name
- INDOPANC (NCT07502053)
- Testing
- No Indocyanine Green, Indocyanine Green
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Pancreatic Fistula
A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy
The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy remains controversial. This study aimed to evaluate the benefits of external and internal stents using the Updated Alternative…
- Trial name
- NCT05725590
- Testing
- External pancreatic duct stent, Internal pancreatic duct stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Tumor
Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Under the hypothesis that collagen-based hemostatic agents improve the suppression of leakage of hemostatic pancreatic fluid at the surgical site during surgery, thrombin-containing collagen-based hemostatic agents are applied in…
- Trial name
- TCM (NCT04357483)
- Testing
- flowable thrombin containing collagen hemostat matrix, thrombin coated L-dopa contained collagen patch
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreas Disease, Complication,Postoperative
Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist)
Main indications for distal pancreatectomy (DP) are pancreatic body and tail tumors including ductal adenocarcinoma, neuroendocrine tumors, and cystic neoplasms.
- Conditions
- Pancreas Disease, Complication,Postoperative, PROMs, Pancreatic Fistula
- Trial name
- Early-Dist (NCT04609137)
- Testing
- Early drain removal, Standard drain removal
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Post Operative Pancreatic Fistula
Does Reinforcement of the Staple Line in Left Pancreatectomy Reduce the Rate of Pancreatic Fistula?
Dividing pancreas when performing left-sided resections opens the risk for leakage from the divided end of the pancreas. Pancreatic juices could have a severe effect on surrounding abdominal tissues with abscess formation…
- Trial name
- NCT02149446
- Testing
- Surgisis (C-SLRA-ECH60) made by COOK Medical
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Ampullary Cancer, Bile Duct Cancer
Modified vs Conventional Blumgart Anastomosis of LPD for the Effects of Pancreatic Fistula of Periampullary Carcinoma
The incidence rate and mortality rate of periampullary cancer at home and abroad both show an increasing trend, seriously affecting the health level of the people.
- Conditions
- Ampullary Cancer, Bile Duct Cancer, Pancreas Cancer, Duodenum Cancer
- Trial name
- NCT06076252
- Testing
- Modified Blumgart Anastomosis in LPD, conventional Blumgart anastomosis in LPD
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Pancreatic Leak, Pancreatic Fistula
A Phase II Trial of Lanreotide for the Prevention of Postoperative Pancreatic Fistula
This is a single arm investigator-initiated study designed to test the feasibility and potential efficacy of preoperative lanreotide to reduce the risk of postoperative abscess or pancreatic leak and fistula.
- Conditions
- Pancreatic Leak, Pancreatic Fistula, Pancreaticoduodenal; Fistula, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03174353
- Testing
- Lanreotide Prefilled Syringe
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Washington
Pancreas Neoplasm
The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF).
- Trial name
- NLR (NCT04724551)
- Testing
- pancreatoduodenectomy (PD)
- Volunteers
- 648 people
- Sponsor
- Institut Paoli-Calmettes
Pancreaticoduodenectomy
Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy
Postoperative pancreatic fistula (POPF) especially clinically relevant POPF (CR-POPF; Grades B and C) is one of the critical and challenging post pancreaticoduodenectomy complications.
- Trial name
- NCT07854353
- Testing
- pancreaticoduodenectomy
- Volunteers
- 200 people
- Sponsor
- Assiut University
Pancreatic Fistula
Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy
Pancreaticoduodenectomy is a surgical procedure for removing cancer in the pancreas, the bile system or the duodenum that is associated with a high rate of complications.
- Trial name
- NCT01696903
- Testing
- Pancreaticojejunostomy technique
- Where
- 2 sites in Sweden
- Volunteers
- 123 people
- Sponsor
- Karolinska Institutet
Distal Pancreatic Resections
Pancreatic Stump Closure After Distal Pancreatic Resection
The aim of this study is to investigate whether finnish binding pancreatico-jejunal anastomosis is feasible and prevents the risk for post operative pancreatic fistula after distal pancreeatectomy.
- Trial name
- NCT02113046
- Testing
- pancreatico-jejunal anastomosis, traditional anastomosis
- Where
- Finland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Pancreatic Fistula
Prophylactic Pancreatic Stent for the Prevention of Post Operative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) remains one of the most harmful complications after pancreatic resection. Some studies have indicated that endoscopic pancreatic stenting was effective in the treatment of POPF.
- Trial name
- NCT03822676
- Testing
- Prophylactic pancreatic stent
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Diseases, Pancreatic Neoplasms
POstopeRative Standardization of Care: THe Implementation of Best Practice After Pancreatic Resection
This Nationwide stepped-wedge cluster randomized trial is designed to evaluate if the implementation of a best practice algorithm for postoperative care results in a decrease in incidence of major complications and death after…
- Conditions
- Pancreatic Diseases, Pancreatic Neoplasms, Pancreatic Cancer, Pancreatitis
- Trial name
- PORSCH (NCT03400280)
- Testing
- Best practice algorithm for postoperative care
- Where
- 17 sites in Netherlands
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Pancreaticoduodenectomy
Isolated Pancreatic Loop With Modified Pancreaticojejunostomy
The aim of the present study was to observe whether the modified pancreatico- jejunostomy (PJ ) technique with an isolated pancreatic loop would effectively reduce the POPF rate and overall morbidity after PD
- Trial name
- NCT04843670
- Testing
- duodenopancreatectomy
- Volunteers
- 201 people
- Sponsor
- Université de Sousse
PDAC of the Body and the Tail of the Pancreas, CR- POPF
Oncologic Impact of Pancreatic Fistula
Clinically-relevant post-operative fistula is a major complication after DP, but it did not affect post-operative therapeutic path nor oncologic long-term outcomes.
- Trial name
- POPF-DSS (NCT04348084)
- Where
- France
- Volunteers
- 382 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Fistula
Ultrasound Elastography for Prediction of Postoperative Pancreatic Fistula
The purpose of this study is to assess the value of preoperative objective modalities such as endoscopic ultrasound elastography and magnet resonance imaging in predicting development of postoperative pancreatic fistula in…
- Trial name
- PMPPOPF (NCT02589379)
- Testing
- Pancreatic Resection
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich