Clinical trials: Postoperative Patients
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders
Ramelteon in the Prevention of Post-operative Delirium
This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.
- Conditions
- Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
- Trial name
- RECOVER (NCT02324153)
- Testing
- Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Postoperative Pain, Hernia
A Safety and Efficacy Study of SABER®-Bupivacaine for Pain Following Hernia Repair
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Conditions
- Postoperative Pain, Hernia, Surgery
- Trial name
- NCT00974350
- Testing
- SABER-Bupivacaine
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 124 people
- Sponsor
- Durect
Pain, Postoperative, Medication Adherence
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
Millions of children and adolescents are prescribed opioid pain relievers each year, placing them at risk for serious adverse events and misuse in the home setting.
- Conditions
- Pain, Postoperative, Medication Adherence, Opioid Use, Knowledge, Attitudes, Practice
- Trial name
- STOMP (NCT03287622)
- Testing
- Educational Intervention, Nudge
- Where
- United States
- Volunteers
- 712 people
- Sponsor
- University of Michigan
Pain, Postoperative, Medication Adherence
Scenario Tailored Opioid Messaging Program (STOMP) to Improve Risk Understanding in Young Adults
Legitimate prescription opioid use during adolescence has been associated with later prescription opioid misuse and substance use disorder symptoms during adulthood.
- Conditions
- Pain, Postoperative, Medication Adherence, Opioid Use, Knowledge, Attitudes, Practice
- Trial name
- STOMPYA (NCT03863353)
- Testing
- Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 503 people
- Sponsor
- University of Michigan
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Low Back Pain
Postoperative Opioid Use and Pain Scores in Patients Undergoing Transforaminal Lumbar Interbody Fusion
The purpose of this project is to study the effects of preoperative followed by scheduled intravenous acetaminophen on pain control for 24 hours postoperatively after minimally invasive 1 or 2 level transforaminal lumbar…
- Trial name
- NCT02061774
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Post Operative Pain
Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied.
- Trial name
- NCT00385541
- Testing
- Morphine PCA, Hydromorphone PCA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy Before or After Surgery in Treating Patients With Colorectal Cancer With Liver Metastases That Could Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy work in different ways to kill tumor cells or stop them from growing. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that…
- Trial name
- NCT01189227
- Testing
- Postoperative chemotherapy, Perioperative chemotherapy
- Where
- 283 sites in United States
- Volunteers
- 9 people
- Sponsor
- NSABP Foundation Inc
Surgical Site Infection, Vaginal Surgery
Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery
This is a randomized trial comparing the effectiveness of 4 vaginal prep solutions (betadine, baby shampoo, TechniCare and Peridex) on reducing bacterial colony counts during surgery preparation.
- Trial name
- NCT03854370
- Testing
- Betadine, Peridex, TechniCare
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wright State University
Resident Knowledge and Attitudes Regarding Cross-cultural Care, Interpersonal and Communication Skills in Patient-clinician Encounters
The Provider Awareness and Cultural Dexterity Toolkit for Surgeons Trial
This study is designed to test the impact of a new curriculum, called Provider Awareness Cultural Dexterity Toolkit for Surgeons (PACTS), on surgical residents' cross-cultural knowledge, attitudes, and skills surrounding the care…
- Conditions
- Resident Knowledge and Attitudes Regarding Cross-cultural Care, Interpersonal and Communication Skills in Patient-clinician Encounters, Patient-reported Satisfaction With Resident Physicians Involved in Their Care, Patients' Clinical Health Outcomes After Surgery
- Trial name
- PACTS (NCT03576495)
- Testing
- PACTS curriculum, Standard Residency Curriculum
- Where
- 8 sites in United States
- Volunteers
- 2,901 people
- Sponsor
- Brigham and Women's Hospital
Postoperative Complications, Neuromuscular Blockade
The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications
Substantial respiratory morbidity has been associated with postoperative residual paralysis, which is fairly common after general anesthesia involving a neuromuscular blocking agent.
- Trial name
- NCT02861131
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Short Bowel Syndrome
Metabolic Balance Study of Apraglutide in Patients With Short Bowel Syndrome, Intestinal Failure (SBS-IF) and Colon-in-Continuity (CIC)
The primary objective of the trial is to evaluate the safety of apraglutide in adult subjects with SBS-IF and CIC.
- Trial name
- STARSnutrition (NCT04964986)
- Testing
- Apraglutide
- Where
- 2 sites in Belgium, France
- Volunteers
- 10 people
- Sponsor
- VectivBio AG
Coronary Artery Disease
Heparin Dose and Post Operative Bleeding in Cardiopulmonary Bypass Patients
Blood is anticoagulated using a drug named heparin during open-heart surgery to allow it to safely pass through the heart-lung machine which pumps the blood throughout the body during the surgery.
- Trial name
- NCT01574105
- Where
- 2 sites in Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Single-ventricle, Heart Diseases
Colchicine in Postoperative Fontan Patients
The investigators found that there is inflammation in the chest drainage in patients after the Fontan operation. The investigators want to test the theory that Colchicine, an anti- inflammatory medication, can decrease the…
- Trial name
- CPFP (NCT03575572)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan
Arteriovenous Fistula, Arteriovenous Graft
Automated 3D Ultrasound-based Surveillance of Arteriovenous Fistula Maturation for Post-operative Hemodialysis Patients
This is a two stage, prospective, multi-center study to evaluate the EchoMark and EchoSure devices in patients undergoing peripheral arteriovenous fistula creation for hemodialysis access.
- Trial name
- NCT04017910
- Testing
- EchoMark/EchoSure
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Sonavex, Inc.
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Pain, Postoperative
Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery
This prospective, randomized, double-blind study will enroll nonsmoking female subjects undergoing laparoscopic bariatric surgery under general anesthesia.
- Trial name
- NCT01194089
- Testing
- Nasal Nicotine Spray, Nasal Normal Saline Spray
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Toby Weingarten
Acromegaly
A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.
If someone is diagnosed with a pituitary tumor that causes acromegaly (too much growth hormone) the treatment is to have it surgically removed. This study has two phases.
- Trial name
- NCT01861717
- Testing
- lanreotide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Saint John's Cancer Institute