Clinical trials: Postoperative Pulmonary Complication
Post Operative Pulmonary Complications, Neuromuscular Blockade
Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease.
- Conditions
- Post Operative Pulmonary Complications, Neuromuscular Blockade, General Anesthesia
- Trial name
- NCT07203287
- Testing
- Rocuronium, Cisatracurium, Sugammadex
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiac Surgery, Ultrasound-guided Parasternal Block
Evaluation of the Effect of Para-sternal Block on Postoperative Respiratory Function After Cardiac Sternotomy Surgery
Postoperative pain after cardiac surgery is associated with reduced postoperative respiratory function. There is an association between greater pain and more pronounced decreases in lung volumes postoperatively.
- Conditions
- Cardiac Surgery, Ultrasound-guided Parasternal Block, Postoperative Pulmonary Complications, Pulmonary Function Testing
- Trial name
- PARACARD (NCT05515809)
- Testing
- parasternal block, Standard pain management
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Laparoscopy, Positive End Expiratory Pressure (PEEP)
Effects of Different Peep Applications on Tissue Oxygenation, Respiratory Mechanics and Postoperative Pulmonary Complications in Laparoscopic Hysterectomy Operations
This study aims to compare the effects of two different PEEP levels (5 cmH₂O and 10 cmH₂O) during laparoscopic hysterectomy on perioperative tissue and cerebral oxygenation, respiratory mechanics, and postoperative pulmonary…
- Conditions
- Laparoscopy, Positive End Expiratory Pressure (PEEP), Respiratory Mechanics
- Trial name
- NCT07105293
- Testing
- PEEP 5 cmH2o applied group, PEEP 10 cmH2o applied group
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
One-Lung Ventilation
Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery
One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to…
- Trial name
- NCT02963025
- Testing
- PEEP level, Use of recruitment maneuvers
- Where
- 79 sites in United States, Albania and 27 more
- Volunteers
- 2,200 people
- Sponsor
- Technische Universität Dresden
Anesthesia, Preoxygenation
Preoxygenation Before General Anesthesia
Rationale of the study: we aim to clarify the question (related to still unclear and not univocal response) about the protective or unnecessary role of preoxygenation in non-critically ill patients (otherwise with no high risk of…
- Trial name
- PREOX2018 (NCT03802643)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Parma
Postoperative Complications, Cancer
Predictive Value of Ariscat Index In The Development of Pulmonary Complication After Major Abdominal Cancer Surgery
The term postoperative pulmonary complication is the development of any complications affecting the respiratory system after anesthetic and surgery procedures.
- Conditions
- Postoperative Complications, Cancer, Pulmonary Complication, Atelectasis
- Trial name
- NCT04663958
- Testing
- Detection / Screening
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Postoperative Hypoxemia
Optiflow® to Prevent Post-Extubation Hypoxemia afteR Abdominal Surgery (the OPERA Trial)
To evaluate whether early application of nasal high flow oxygen therapy after extubation can reduce the incidence of postoperative hypoxemia (defined as a PaO2/FiO2 ratio <300) after abdominal surgery in patients with…
- Trial name
- OPERA (NCT01887015)
- Testing
- Nasal high flow cannula (OptiflowTM, MR850 heated humidified, Fisher & Paykel Healthcare, Auckland, New Zealand)
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pulmonary Complications
Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position
Postoperative pulmonary complications are main cause of overall perioperative morbidity and mortality in the patients following general anesthesia.
- Trial name
- NCT02373475
- Testing
- Conventional ventilation, Protective lung ventilation
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
Surgery-Complications, Respiratory Complication
Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
This will be a randomized, placebo-controlled, double-blinded, pilot trial with two parallel groups (1:1 ratio) receiving either dexmedetomidine (initial bolus of 1 mcg/kg over 30 min after induction, followed by an infusion rate…
- Conditions
- Surgery-Complications, Respiratory Complication, Lung Injury, Acute
- Trial name
- NCT06502002
- Testing
- Dexmedetomidine Hydrochloride
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Complications, Surgery
A Multi-center Randomized Clinical Trial About Using LMA or ETI in Elderly Patients
Perioperative airway management is a top priority of anesthesiologists in daily work, and endotracheal intubation (ETI) is considered as the gold standard for providing safe glottic seal,effective ventilation and oxygen…
- Trial name
- LMA;ETI (NCT02240901)
- Testing
- Laryngeal mask airway（LMA）, Endotracheal intubation（ETI）
- Where
- China
- Volunteers
- 2,900 people
- Sponsor
- RenJi Hospital
Observation of Neuromuscular Block, Complication of Ventilation Therapy
Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery
The aim of this project is to show, whether the use of the deep neuromuscular block in certain laparoscopic robot-assisted surgery can positively influence main physiological functions compared to the use of standard…
- Conditions
- Observation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative Recovery
- Trial name
- NCT03420937
- Testing
- Sugammadex, Neostigmine, Atropin Biotika
- Where
- Czechia
- Volunteers
- 138 people
- Sponsor
- University Hospital Olomouc
Hepatopulmonary Syndrome, Liver Cirrhosis
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations.
- Trial name
- HPS (NCT03092401)
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon
Postoperative Pulmonary Atelectasis, Pneumothorax
Cardiopulmonary Bypass on Mechanical Power and Postoperative Pulmonary Complications
During cardiopulmonary bypass (CPB), oxygenation of the patient on the pump can be left completely under pump control, or the lungs can be ventilated with low tidal volume to reduce atelectasis.
- Conditions
- Postoperative Pulmonary Atelectasis, Pneumothorax, Pneumonia, Ards
- Trial name
- NCT06292767
- Testing
- mechanical power calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- TC Erciyes University
Postoperative Delirium, Adult Cardiac Surgery
Incidence of Postoperative Delirium After Cardiac Surgery in Adults.
Postoperative delirium is an acute syndrome of mental deterioration characterized by acute onset and fluctuating course during the day.
- Conditions
- Postoperative Delirium, Adult Cardiac Surgery, Covid19
- Trial name
- NCT04828902
- Testing
- cardiac surgery
- Where
- Poland
- Volunteers
- 610 people
- Sponsor
- Medical University of Gdansk
Acute Lung Injury
The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications
Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis…
- Trial name
- lung (NCT07477951)
- Testing
- Automated recruitment maneuver (Auto-RM)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Yongtao Sun
Postoperative Pulmonary Complication
The Effect of Alveolar Recruitment Maneuver in Laparoscopic Surgery
Investigating the effect of alveolar recruitment on the incidence of postoperative pulmonary complication in patients who undergo laparoscopic surgery
- Trial name
- NCT03681236
- Testing
- Alveolar recruitment maneuver
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Seoul National University Bundang Hospital
Surgery, Ventilator Lung
Mechanical Ventilation in Surgical Patients
This is an investigator-initiated, international, multicenter, prospective, cross-sectional study that aims to 1) describe the incidence and types of postoperative pulmonary complications (PPCs), 2) describe patient demographics…
- Conditions
- Surgery, Ventilator Lung, Postoperative Complications
- Trial name
- MEET VENUS (NCT06296277)
- Testing
- Intraoperative mechanical ventilation for surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Postoperative Pulmonary Complications (PPCs), Hypoxemia
Lung Ultrasound Score and Postoperative Pulmonary Complications in Major Non-Thoracic Surgery
This prospective observational cohort study aims to evaluate the predictive value of perioperative lung ultrasound (LUS) score in determining early postoperative oxygen requirement and pulmonary complications in patients…
- Trial name
- LUS-POSTOP (NCT07515001)
- Volunteers
- 97 people
- Sponsor
- Dicle University
Gynecologic Surgery, High-flow Nasal Cannula
A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms
Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses…
- Conditions
- Gynecologic Surgery, High-flow Nasal Cannula, Post-operative Pulmonary Complications
- Trial name
- NCT05526534
- Testing
- heated humidified high flow nasal cannula oxygen therapy, HFNC, Nasal cannula oxygen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Surgery, Covid19
GlobalSurg-CovidSurg Week
Observational study to determine the optimal timing for surgery following SARS-CoV-2 infection and assess key global surgery indicators.
- Conditions
- Surgery, Covid19, Post-Op Complication
- Trial name
- NCT04509986
- Volunteers
- 1,000 people
- Sponsor
- University of Birmingham