Clinical trials: Postoperative Pulmonary Complication
Lung Cancer
Randomized Study on Effects of Uniportal VATS Versus Triportal VATS
For the treatment of stage I-II NSCLC, two mini-invasive techniques are mostly utilized: uni-portal and three-portal VATS. In the uniportal approach, the injury on a single intercostal space could determine a lower level of pain…
- Trial name
- NCT03240250
- Testing
- VATS uni-portal lobectomy and lymphoadenectomy, VATS three-portal lobectomy and lymphoadenectomy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
PONV
Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer Surgery
This prospective, randomized controlled study aims to evaluate the efficacy and safety of electroacupuncture combined with 5-HT3 receptor inhibitor for preventing postoperative nausea and vomiting (PONV) in high-risk patients…
- Trial name
- NCT07515027
- Testing
- Prophylactic administration of dolasetron, Electroacupuncture
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Chest Hospital
Atelectasis, Postoperative, Pulmonary Complication
Evaluation of Perioperative Lung Ultrasound Scores (LUS) in Living Donor Nephrectomy Surgeries
Living donor nephrectomy surgeries can be performed in lateral position with laparoscopic technique which necessitates pneumoperitoneum. Considering the position and the pneumoperitoneum, lungs can be affected macroscopically.
- Trial name
- NCT05815888
- Testing
- Lung Ultrasound Score
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University
One Lung Ventilation in Thoracic Surgery
Oxygen Reserve Index Guided FiO₂ Titration in One-Lung Ventilation
One-lung ventilation (OLV) is routinely used during thoracic surgery to facilitate surgical exposure but is associated with an increased risk of intraoperative hypoxemia.
- Trial name
- NCT07359833
- Testing
- Oxygen Reserve Index (ORi)-guided oxygen titration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Smoking ( Cigarette)
Effectiveness of Brief Smoking Cessation Counselling in Pre-Anaesthesia Assessment Clinic
The goal of this clinical trial is to evaluate whether a brief, nurse-delivered smoking cessation intervention can increase pre-operative smoking abstinence and improve perioperative outcomes among adult elective surgical…
- Trial name
- NCT07505147
- Testing
- Nurse-led AWARD brief smoking cessation counselling with active referral and tailored perioperative booklet in the pre-anaesthetic assessment clinic, Usual pre-anaesthetic care without structured smoking cessation
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Pok Oi Hospital
Lung Cancer (Diagnosis), Pulmonary Complications in Surgical Patients
Effect of Mechanical Power-based Lung-protective Ventilation During One-lung Ventilation
The goal of this clinical trial is to determine whether a mechanical power-based lung-protective ventilation strategy during one-lung ventilation reduces the incidence of postoperative pulmonary complications in adult patients…
- Trial name
- NCT07772804
- Testing
- Mechanical power-based lung protective ventilation, Conventional lung protective ventilation
- Where
- South Korea
- Volunteers
- 164 people
- Sponsor
- Samsung Medical Center
Pulmonary Hypertension, Thromboembolism, Pulmonary
Perioperative Portal Vein Pulsatility as a Postoperative Prognostic Indicator in Pulmonary Endarterectomy
The investigators aim to evaluate the utility of portal vein pulsatility as a predictor of the composite outcome of persistent organ dysfunction plus death in patients undergoing elective or urgent pulmonary endarterectomy for…
- Conditions
- Pulmonary Hypertension, Thromboembolism, Pulmonary, Perioperative/Postoperative Complications, Venous Hypertension
- Trial name
- PVP-ETO-CPC (NCT03197792)
- Testing
- All patients
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Primary Graft Dysfunction
Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation
Primary graft dysfunction (PGD or lung reperfusion edema) complicates 10 to 20% of lung transplantations and leads to severe early and late postoperative complications.
- Trial name
- NCT01151826
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Strasbourg, France
Prostate Cancer, Lung Protective Ventilation
Evaluating Respiratory Effects of Driving Pressure Guided Mechanical Ventilation Using Electrical Impedance Tomography in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Robot-Assisted Laparoscopic Radical Prostatectomy is a method increasingly used for prostate cancer due to fewer complications, morbidity, and mortality compared to other methods.
- Conditions
- Prostate Cancer, Lung Protective Ventilation, Postoperative Pulmonary Complications
- Trial name
- NCT06540794
- Testing
- PEEP TITRATION
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University
Postoperative Respiratory Complications
PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery
The purpose of this international, multicentre, double-blinded randomized controlled trial is to determine if the "open lung approach" providing recruitment maneuvers and PEEP(Positive End Expiratory Pressure) during general…
- Trial name
- PROVHILO (NCT01441791)
- Testing
- Lung protective strategy ventilation
- Where
- 30 sites in United States, Austria and 8 more
- Volunteers
- 900 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Pulmonary Complications
Mechanical Power and Driving Pressure Exposure in Laparoscopic Surgery
Postoperative pulmonary complications (PPCs) remain an important cause of morbidity after abdominal surgery. Intraoperative mechanical ventilation may contribute to lung injury through the mechanical load applied to the…
- Trial name
- NCT07431242
- Testing
- Intraoperative Ventilatory Load Exposure (Mechanical Power and Driving Pressure)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istinye University
Thoraric Surgery, Surgery Time Expected More Than Two Hours
Individualized Perioperative Open-Lung Ventilatory Strategy During One-Lung Ventilation
The purpose of this study is to determine whether individualized ventilatory management during one-lung ventilation in patients scheduled for thoracic surgery, combining the use of low tidal volumes, alveolar recruitment…
- Trial name
- iPROVE-OLV (NCT03182062)
- Testing
- Alveolar recruitment maneuver, PEEP Titration Trial, Lung protective ventilation
- Where
- 4 sites in Spain
- Volunteers
- 1,400 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Postoperative Complications
ARISCAT, ASA and LAS VEGAS Risk Scores and the Incidence of Postoperative Pulmonary Complications in Thoracic Surgery
Postoperative pulmonary complications (PPC) are among the main complications after the anesthetic-surgical procedure. It can be said that thoracic surgery results in impaired respiratory function in the postoperatively, due to…
- Trial name
- NCT06404892
- Testing
- Single-lung ventilation
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
URTI, Postoperative Complications
Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic
The goal of this observational study is to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional…
- Conditions
- URTI, Postoperative Complications, COVID - 19, Elective Non-cardiac Surgery
- Trial name
- URTI (NCT07157111)
- Where
- China
- Volunteers
- 2,392 people
- Sponsor
- aijun xu
Lung Cancer, Postoperative Pain
The Effects of Programmed Death-ligand 1 on Postoperative Pain for Lung Cancer Patients
The concentration of plasma programmed death-ligand 1(PD-L1) for lung cancer patients before video-assisted thoracoscopic surgery is detected.
- Trial name
- NCT06503432
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Postoperative Respiratory Failure, Abdominal Surgery
Mechanical Power for Ventilatory Settings in Operating Room
Postoperative respiratory failure (PRF) is a dreaded complication that imposes a significant burden through unplanned admission to the ICU, post discharge disability and mortality.
- Conditions
- Postoperative Respiratory Failure, Abdominal Surgery, Postoperative Pulmonary Complications, Morality
- Trial name
- IMPROVEIII (NCT07620132)
- Testing
- Mechanical power-guided ventilatory strategy, Standard fixed ventilatory settings
- Volunteers
- 490 people
- Sponsor
- University Hospital, Montpellier
Postoperative Delirium (POD)
Dexmedetomidine Nasal Spray on Postoperative Delirium in Elderly Thoracoscopic Lung Resection Patients
This clinical trial is designed to observe the effect of dexmedetomidine nasal spray on the incidence of postoperative delirium in elderly patients undergoing thoracoscopic lung resection.
- Trial name
- NCT07579806
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Mechanical Ventilation Complication, Surgery
Intraoperative Hypocapnia in PROVHILO and PROBESE
To gain a better understanding of the epidemiology of intraoperative hypocapnia, in particular the associations of intraoperative hypocapnia with patient demographics, ventilator characteristics, and perioperative complications…
- Conditions
- Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative Complications
- Trial name
- iHypoPRO (NCT05550181)
- Testing
- intraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)
- Where
- 4 sites in Brazil, Germany and 2 more
- Volunteers
- 2,793 people
- Sponsor
- NMC Specialty Hospital
Thoracic Surgery, Postoperative Pulmonary Complications (PPCs)
Perioperative Inhaled Therapy in Carcinological Thoracic Surgery in Patients at High Risk of Postoperative Pulmonary Complications
The objective of the study is to evaluate, in a clinical trial, the efficacy of peri operative administration of long-acting inhaled ß-2 mimetics on the occurrence of postoperative pulmonary complications
- Trial name
- TICTAC (NCT06865040)
- Testing
- Formoterol Fumarate 12 mcg (Foradil Aerolizer), Usual treatment
- Where
- France
- Volunteers
- 266 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens