Clinical trials: Postpartum Bleeding
Postpartum Hemorrhage, Treatment Outcome
Long Term Outcome After Use of Vacuum-induced Tamponade for Postpartum Hemorrhage
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period (2017-2025).
- Conditions
- Postpartum Hemorrhage, Treatment Outcome, Pregnancy Outcome
- Trial name
- LOVIT (NCT07885072)
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich
Post Partum Haemorrhage
Intramuscular Oxytocics: A Randomised Control Trial
A quarter of all pregnancy and child-birth related deaths are due to excessive bleeding after the birth, "post-partum haemorrhage" (PPH). In the UK, PPH affects approx 10% of new mothers.
- Trial name
- IMox (NCT02216383)
- Testing
- Carbetocin, Syntocinon, Syntometrine
- Where
- 5 sites in United Kingdom
- Volunteers
- 5,798 people, healthy volunteers welcome
- Sponsor
- North Bristol NHS Trust
Intrapartum - Moderate and Severe Anaemia
World Maternal Antifibrinolytic Trial_2
Postpartum haemorrhage (PPH) is responsible for about 100,000 maternal deaths every year, almost all of which occur in low and middle income countries.
- Trial name
- WOMAN-2 (NCT03475342)
- Testing
- Tranexamic Acid
- Where
- 41 sites in Nigeria, Pakistan and 2 more
- Volunteers
- 15,068 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Simulation Training, Nursing
The EFFECT of SIMULATION-BASED TRAINING on POSTPARTUM HAEMORRHAGE MANAGEMENT SKILLS
This study was planned to determine the effect of simulation-based training using two different reality levels-visually enhanced mental simulation (VEMS) and hybrid simulation-on postpartum haemorrhage (PPH) management skills in…
- Conditions
- Simulation Training, Nursing, Postpartum Hemorrhage
- Trial name
- (SBT) (NCT06872879)
- Testing
- VEMS Simulation, Hybrit Simulation
- Volunteers
- 64 people
- Sponsor
- Bandırma Onyedi Eylül University
Postpartum Hemorrhage
Efficacy of Balloon Tamponade in Post-partum Hemorrhage Within 24 Hours After Delivery
Postpartum hemorrhage (PPH) is a major cause of maternal death, especially in developing countries like Pakistan where it accounts for up to 34% of maternal deaths.
- Trial name
- BT-PPH (NCT07845240)
- Testing
- Intrauterine Balloon Tamponade - Condom Catheter
- Where
- Pakistan
- Volunteers
- 121 people
- Sponsor
- Aziz Fatimah Medical & Dental College, Faisalabad
High Risk Postpartum Hemorrhage (PPH)
ROTEM® Obstetric Hemorrhage Pilot Study
This is a prospective observational study among women at high-risk of postpartum hemorrhage, in their third trimester who are admitted to Labor \&Delivery in spontaneous labor, for induction of labor, or for scheduled cesarean…
- Trial name
- NCT04409015
- Testing
- ROTEM - rotation thromboelastometry testing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Postpartum Hemorrhage
Comparing Misoprostol and Oxytocin in UnijectTM for Postpartum Hemorrhage (PPH) Prevention in Mali
This is a large, community-based, cluster-randomized trial to compare routine prophylactic use of 600 mcg oral misoprostol and 10 IU oxytocin delivered by UnijectTM intramuscularly during the third stage of labor.
- Trial name
- NCT01487278
- Testing
- misprostol, UnijectTM
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage, Postpartum Preeclampsia
Postpartum Video Education
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Preeclampsia, Postpartum Sepsis, Postpartum Depression
- Trial name
- NCT05159726
- Testing
- Video Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Post Partum Hemorrhage
Mostafa Maged Maneuveur to Prevent and Control Post-partum Haemorrhage During Normal Vaginal Delivery
PPH is commonly defined as blood loss exceeding 1000 milliliters after vaginal birth or cesarean section.1 PPH is often classified as primary/immediate/early (occurring within 24 hours of birth) or secondary/delayed/late…
- Trial name
- NCT05288322
- Testing
- Mostafa Maged maneuver
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University
Postpartum Hemorrhage
Routine Bilateral Uterine Artery Ligation During the Cesarean Delivery of Multiple Gestation
Multiple pregnancy is well defined to be associated with a greater risk of postpartum blood loss . Interventions to control PPH generally stepped from less to more invasive and including compression maneuvers , drugs , and…
- Trial name
- NCT05670886
- Testing
- uterine artery ligation
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Postpartum Hemorrhage
Prediction of Postpartum Hemorrhage With Uterine Artery Doppler Measurement
The aim of the study is to evaluate the uterine artery doppler just before labour in term low risk pregnancies. And to investigate with this measurement if investigators could foreseen the amount of postpartum hemorrhage looking…
- Trial name
- NCT03229304
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Postpartum Hemorrhage
Evaluating the Safety and Efficacy of RUCS in PPH
This retrospective observational study aims to evaluate the efficacy and safety of Removable Uterine Compression Sutures (RUCS) in the surgical management of postpartum hemorrhage (PPH).
- Trial name
- RUCS-PPH (NCT07115355)
- Testing
- Removable Uterine Compression Suture (RUCS)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Havva Betül Bacak
Postpartum Hemorrhage
Intramuscular Versus Intravenous Prophylactic Oxytocin for Hemorrhage After Vaginal Delivery
Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour following vaginal delivery: A randomised controlled trial
- Trial name
- oxytocin (NCT02080104)
- Testing
- intarvenous and intramusculer 10 IU oxytocin
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Hediye Dagdeviren
Postpartum Hemorrhage (PPH), Placental Dysfunction
Risk Factors for Postpartum Hemorrhage in Patients With Histologically Verified Placenta Accreta
This retrospective, monocentric study aims to examine risk factors for postpartum hemorrhage in women with histologically verified placenta accreta.
- Trial name
- NCT05542043
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 2,348 people
- Sponsor
- University Hospital, Basel, Switzerland
Postpartum Hemorrhage， Cesarean Section
A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women
One hundred forty low risk pregnant women scheduled for elective cesarean delivery were randomized (1:1) into two groups: the intrauterine group (n=70) received 400 μg misoprostol (200 μg at each uterine cornu) after placental…
- Trial name
- NCT07728084
- Testing
- Misoprostol Tabets
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Post-Partum Hemorrhage
Fibrinogen in Haemorrhage of Delivery
The purpose of the study is to assess the benefits of a therapeutic strategy that associates an early administration of human fibrinogen concentrate in the management of PPH on the reduction of bleeding after the initiation of…
- Trial name
- FIDEL (NCT02155725)
- Testing
- Human Fibrinogen concentrate
- Where
- 31 sites in France, Martinique
- Volunteers
- 448 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Postpartum Hemorrhage
Postpartum Hemorrhage: Incidence and Risk Factors
Postpartum hemorrhage(PPH) is a major cause of maternal morbidity and mortality across the world. Incidence of PPH varies in the literature from 2 to 10%, most recent studies find around 10% of PPH and 2% of severe PPH.
- Trial name
- NCT05525143
- Testing
- Pregnant women who have given birth vaginally or by cesarean section
- Where
- Belgium
- Volunteers
- 2,402 people
- Sponsor
- Brugmann University Hospital
Postpartum Hemorrhage
A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects
Carbetocin is an oxytocin receptor agonist that selectively binds to receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the…
- Trial name
- NCT05924321
- Testing
- Carbetocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals