Clinical trials: Postpartum Hemorrhage,
Postpartum Hemorrhage, Carbetocin
Timing of Carbetocin Administration in Postpartum Hemorrhage
Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH.
- Trial name
- NCT06776926
- Testing
- Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mehmet Mete Kırlangıç
Hysterectomy (MeSH nr: E04.950.300.399)
Transforming Global Surgery Capacity and Capability Through Affordable Virtual Reality
The goal of this randomized controlled trial was to evaluate whether Deliberate Virtual Reality (VR) training can improve surgical skills, knowledge, and confidence in performing postpartum hysterectomy among junior-level Zambian…
- Trial name
- NCT07403526
- Testing
- Deliberate Virtual Reality (VR) Training, Standard Clinical Training
- Where
- Zambia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Postpartum Hemorrhage
Impact of Uterotonic Agents on Isolated Human Myometrium
The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs.
- Trial name
- NCT00989027
- Testing
- Oxytocin, Ergonovine, Carboprost
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Obesity, Maternal, Post Partum Hemorrhage
Efficacy of Carbetocin in Prevention of Postpartum Hemorrhage in Obese Versus Non Obese Women
Postpartum hemorrhage [PPH] can have serious consequences and is the leading cause of maternal mortality globally. Uterine contractility plays an important role in post-delivery uterine involution; impaired contractility can…
- Trial name
- NCT06217354
- Testing
- Carbetocin 100 Microgram/mL Solution for Injection
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hemorrhage Postpartum, Fertility Disorders
Fertility After Intrauterine Tamponing Balloon: Where Are we
Today, few data are available on the patient's fertility following intrauterine tamponade balloon (BTIU) used for postpartum hemorrhage (PPH) after vaginal delivery (AVB).
- Trial name
- FERTIBTIU (NCT04133402)
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Postpartum Hemorrhage
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
This study will investigate the effects of drugs called "uterotonics" that help with the contraction of the uterus after a baby is born. This uterine contraction is very important to stop the bleeding after delivery.
- Trial name
- NCT06285409
- Testing
- Carbetocin, Oxytocin, Ergonovine
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Placenta Previa
Intra-myometrial Vasopressin During Cesarean Section in Placenta Previa
Placenta previa can have serious adverse consequences for the mother, including an increased risk of maternal mobility, antenatal and intrapartum hemorrhage, and the mother may, therefore, require a blood transfusion or even an…
- Trial name
- NCT03725553
- Testing
- Intramyometrial Vasopressin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
Postpartum Hemorrhage
The Association Between Shock Index and Severity of Postpartum Blood Loss
The present study aims to determine the relationship between postpartum changes in the shock index and the severity of blood loss and other PPH results.
- Trial name
- NCT03135158
- Testing
- Exposure to vaginal delivery
- Where
- Colombia
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery
The aim is to assess the impact of tranexamic acid (TXA) for preventing postpartum hemorrhage (PPH) following a cesarean section (CS).
- Trial name
- TRAAP2 (NCT03431805)
- Testing
- Tranexamic Acid Injectable Solution, Sodium Chloride 0.9%
- Where
- 26 sites in France
- Volunteers
- 4,574 people
- Sponsor
- University Hospital, Bordeaux
ıntrapartum Haemorrhage, Postpartum Haemorrhage
The Effect of Rectal and Sublingual Misoprostol Administration in Postpartum or Intrapartum Haemorrhage at Elective Caesarean Delivery: a Randomized Controlled Trial
The investigators hypothesis in this study is that administration of rectal and sublingual misoprostol decreases intrapartum and postpartum haemorrhage.
- Trial name
- NCT01931410
- Testing
- Misoprostol
- Volunteers
- 618 people
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Cesarean Section Complications
Carbetocin Versus Oxytocin Infusion Plus Tranexamic Acid During Cesarean Section
Purpose to evaluates the effects of oxytocin infusion with or without intravenous tranexamic acid (TA) in comparison with Carbetocin for prevention of postpartum hemorrhage at a cesarean section with one or more risk factor for…
- Trial name
- NCT03777878
- Testing
- Carbetocin, oxytocin, TA
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Aswan University Hospital
Postpartum Hemorrhage
The Foley's Catheter Balloon to the Bleeding From Placenta Previa
Post-partum haemorrhage due to placenta previa is usually from the placental bed at the lower uterine segment and it occurs after the placenta separation.
- Trial name
- NCT02640885
- Testing
- Foley's cather ballon
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Uterine Atony, Uterine Tone Disorders
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections
Insufficient uterine tone resulting in atony can potentiate hemorrhage and adverse outcomes for the parturient. Oxytocin is the first pharmacologic agent used, followed by methylergonovine, carboprost, and misoprostol.
- Conditions
- Uterine Atony, Uterine Tone Disorders, Postpartum Hemorrhage
- Trial name
- NCT03303235
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postpartum Hemorrhage, Waterbirth
Measured Versus Hemoglobin-Calculated Postpartum Blood Loss in Waterbirth
During a waterbirth, blood lost in the pool between the birth of the baby and the mother's exit from the water cannot be collected or measured.
- Trial name
- NCT07884890
- Testing
- Water immersion during labor and birth
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- University of Campania Luigi Vanvitelli
Management of Delivery
Effectiveness of Placental Drainage in the Third Stage of Labor: a Randomized Clinical Trial
The purpose of this study is to determine if placental drainage shortens third period of labor and reduces postpartum blood lost.
- Trial name
- PLADRAINAGE (NCT01655576)
- Testing
- Placental drainage
- Where
- Brazil
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Postpartum Hemorrhage
Misoprostol as First Aid Measure to Address Excessive Postpartum Bleeding
The overall study purpose is to evaluate the safety, feasibility and acceptability of advance distribution of misoprostol to be used as 'first aid treatment' administered by the woman herself or her family to help treat excessive…
- Trial name
- NCT02853552
- Testing
- Misoprostol
- Volunteers
- 4,330 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Post Partum Hemorrhage
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
Background Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide accounting for 25% of maternal deaths. In Zimbabwe PPH is the second most common cause of death.
- Trial name
- NCT03463993
- Testing
- Tranexamic Acid, Oxytocin
- Where
- 2 sites in Zimbabwe
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Pregnancy; Fetomaternal Hemorrhage
Clinical Efficacy of Postpartum Immunization of Rh and Coombs Negative Women With Sensitization Risk.
This a open, prospective, multicenter, single-arm, phase III study for clinical assessment of anti-Rh immunoglobulin (KamRho-D®) in Rh and Coombs negative women with risk sensitization.
- Trial name
- NCT01666249
- Testing
- Immunoglobulin Anti-RhD
- Where
- 5 sites in Brazil
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Cesarean Section, Hypotension
Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia
This study compares two standard ways of giving oxytocin (a medicine that helps the uterus contract) after the baby is born during a planned caesarean section performed under spinal anaesthesia.
- Conditions
- Cesarean Section, Hypotension, Postpartum Hemorrhage, Spinal Anesthesia
- Trial name
- NCT07784478
- Testing
- Oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Girls Medical College