Clinical trials: Postpartum Pregnancy-Induced Hypertension
Microalbuminuria, Preeclampsia
Lisinopril for Renal Protection in Postpartum Preeclamptic Women
There may be a role for Lisinopril in improving renal protection in post-partum women who had preeclampsia during pregnancy. The aim of this study is to determine whether routine initiation of Lisinopril after delivery, in women…
- Trial name
- NCT05016440
- Testing
- Lisinopril
- Where
- United States
- Sponsor
- Eastern Virginia Medical School
Pre-Eclampsia, Gestational Hypertension
Physician Optimised Post-partum Hypertension Treatment Trial
It has been shown in a pilot randomised controlled study [SNAP-HT [4]; REC 14/SC/1316] that blood pressure self-management during the post-partum period after hypertensive pregnancies, results in lower blood pressure after six…
- Trial name
- POP-HT (NCT04273854)
- Testing
- OMRON Evolv® blood pressure monitor (Blue-tooth® enabled) & Proprietary Smartphone POP-HT app®
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Gestational Diabetes Mellitus, Hypertension in Pregnancy
Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)
STEP-UP will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (GDM) and/or hypertensive disorders of pregnancy (HDP).
- Conditions
- Gestational Diabetes Mellitus, Hypertension in Pregnancy, Dysglycemia
- Trial name
- NCT05852054
- Testing
- OB Provider Clinical Decision Support (CDS), Patient Education (OB Visit), Text messaging
- Where
- 2 sites in United States
- Volunteers
- 2,306 people
- Sponsor
- Northwestern University
Hypertension, Pregnancy Induced
Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension
A multicenter randomized trial that will compare the effectiveness of two postpartum blood pressure (BP) management strategies in improving blood pressure and cardiac function and increasing patient engagement and feeling of…
- Trial name
- SMART BP (NCT07209254)
- Testing
- High-touch blood pressure management, Low-touch blood pressure management
- Where
- 3 sites in United States
- Volunteers
- 770 people
- Sponsor
- Jennifer Lewey, MD, MPH
Preeclampsia Severe, Preeclampsia Postpartum
Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia
The objective of the study is to determine whether administration of vitamin C (1.5g/6 hours) in the first three days post-partum reduces the amount of extravascular lung water assessed by lung ultrasound in patients with severe…
- Trial name
- NCT03451266
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Hypertensive Disorder
Use of a Cloud-connected Remote Blood Pressure Monitoring Program During the Postpartum Period for Hypertensive Women
Hypertensive disorders (HD), including preeclampsia, gestational hypertension, chronic hypertension, and chronic hypertension with superimposed preeclampsia, affect around 10-20% of pregnant women in the United States and are…
- Trial name
- BP-ME (NCT06096701)
- Testing
- Blood pressure cuff
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- University of South Carolina
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Hypertension in Pregnancy, Preeclampsia
Response to Anti-hypertensives in Pregnant and Postpartum Patients
In this study, the investigators will evaluate the blood pressure response to nifedipine and labetalol in pregnant and postpartum patients, who present with hypertensive disease in pregnancy with severe range blood pressure…
- Trial name
- NCT03506724
- Testing
- Nifedipine, Labetalol
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pre-Eclampsia; Complicating Pregnancy, Gestational Hypertension
Remote Postpartum Blood Pressure Monitoring and Cardiovascular Education
The goal of this clinical trial is to learn if patient education and regular text reminders are a feasible intervention to engage patients and reduce post partum hypertension.
- Trial name
- NCT06920563
- Testing
- Video, Text Reminder, Blood pressure threshold
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- Ochsner Health System
Preeclampsia, Preeclampsia Postpartum
Vascular Effects of High-Salt After Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06749418
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Preeclampsia Postpartum
Aspirin for Postpartum Patients With Preeclampsia
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth.
- Trial name
- ASAPP (NCT05924971)
- Testing
- Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- MemorialCare Health System
Hypertension
Prevention of Severe Postpartum Hypertension
The purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours…
- Trial name
- NCT02450773
- Testing
- Furosemide, Potassium chloride
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Preeclampsia Postpartum
Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
- Trial name
- GDMT For PE (NCT05534932)
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Preeclampsia, Postpartum Period
The PreEclampsia Postpartum Prevention Trial
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy.
- Conditions
- Preeclampsia, Postpartum Period, Hypertension, Cardiovascular Diseases
- Trial name
- PEPP (NCT07199283)
- Testing
- Bundle Intervention
- Where
- 2 sites in Sweden
- Volunteers
- 356 people
- Sponsor
- Karolinska Institutet
Hypertension
Validation of Pulsewave Blood Pressure Monitor in Hypertensive and Normotensive Pregnant and Postpartum Women
The purpose of this study is to test the accuracy of the Pulsewave wrist blood pressure cuff in pregnant and postpartum women who have either normal blood pressure or high blood pressure.
- Trial name
- NCT02823873
- Testing
- Pulsewave oscillometric wrist cuff blood pressure monitor
- Where
- United States
- Sponsor
- University of Arkansas
Hypertension in Pregnancy
Persistent Postpartum Hypertension Pilot Trial
This study is a pilot, open-label, randomized controlled trial of postpartum women with hypertensive disorders pregnancy and persistent non-severe blood pressure.
- Trial name
- NCT04349124
- Testing
- Nifedipine Extended-Release Tablets
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Preeclampsia
Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia
Otherwise healthy women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life.
- Trial name
- NCT06157580
- Testing
- Compound 21, Angiotensin II
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Hypertension in Pregnancy, Postpartum Preeclampsia
Rhode Island - Statewide Postpartum Hypertension Remote Surveillance
This is a hybrid type 1 non-inferiority implementation effectiveness trial among postpartum patients with hypertension (N=1536) that will test the hypothesis that RI-SPHERES (a technologically enabled collaborative care model) is…
- Conditions
- Hypertension in Pregnancy, Postpartum Preeclampsia, Postpartum Complication
- Trial name
- RI-SPHERES (NCT06842875)
- Testing
- RI-SPHERES, Standard self-measured blood pressure program
- Where
- 5 sites in United States
- Volunteers
- 1,536 people
- Sponsor
- Women and Infants Hospital of Rhode Island