Clinical trials: Postprandial Glycemic Control
Diabetes Mellitus, Type 1, Type 1 Diabetes
Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Postprandial Hyperglycemia
- Trial name
- NCT04243629
- Testing
- Rapid-Acting Insulin, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University
Obesity, Dyslipidemia
Meta-analyses of the Effect of Sucrose Versus High Fructose Corn Syrup on Cardiometabolic Risk
The rise in high fructose corn syrup (HFCS) consumption over the past 40 years since its introduction as a popular sweetener in the United States has led to much concern regarding its contribution to the rise in obesity (1)…
- Conditions
- Obesity, Dyslipidemia, Prediabetes, Dysglycemia
- Trial name
- NCT02702479
- Testing
- High Fructose Corn Syrup, Sucrose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 1 Diabetes Mellitus
Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus
The aim of this study is to determine whether insulin glulisine is more effective in postprandial glycemic control than insulin aspart after the H-GI meal in children with type 1 diabetes (T1DM) treated with insulin pump (CSII).
- Trial name
- NCT01678235
- Testing
- Insulin glulisine, Insulin aspart
- Where
- Poland
- Volunteers
- 64 people
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus, Type 1
To Compare Influence of Breakfast With and Without Sweeteners on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes
Introduction: Type 1 diabetes is a chronic autoimmune disease with multifactorial etiology, resulting in partial or complete destruction of pancreatic β cells, leading to an absolute deficit of insulin and vital dependence on…
- Trial name
- T1D (NCT06201806)
- Testing
- Test food breakfast with NCS or witout NCS
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- University of Chile
Type 2 Diabetes
Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification
A Randomized Control Trial (RCT) with 1:1 randomization of adults newly diagnosed with type 2 diabetes (T2D) to Routine Care (RC) and RC + Glycemic Excursion Minimization (RC+GEM); a program that provides RC in addition to…
- Trial name
- GEM (NCT05766735)
- Testing
- Routine Care + Glycemic Excursion Minimization (RC+GEM), Routine Care (RC)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Chiara Fabris, PhD
Poor Glycemic Control
Food Design for Improved Day-long Glycaemic Regulation
The study focus is on the possible improvement in glucose tolerance at a second standardized meal that can be achieved when preceded by a test meal with a low GI and a high GP.
- Trial name
- NCT02876029
- Testing
- Reference, Test product
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Glycemic Response
Glin3: Assessment of the Glycemic Responses to Nutritional Products
This study assesses the glycemic responses to nutritional products. During a study visit fasted subjects will consume one serving of the reference product or the test product.
- Trial name
- GLIN#3 (NCT06215534)
- Testing
- first reference product series 1, second reference product seies 1, third reference product series 1
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Type 1 Diabetes Mellitus
Postprandial Blood Glucose Control With BioChaperone® Combo and Insulin Lispro (Humalog®) Mix 25 in People With Type 1 Diabetes Mellitus
Each subject will be randomly allocated to a sequence of two treatments applied at two separate dosing visits. At each dosing visit subjects will be injected with individualised doses of either BioChaperone® Combo or Humalog® Mix…
- Trial name
- NCT02514954
- Testing
- Biochaperone® Combo, Humalog® Mix25
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Adocia
Type 2 Diabetes Treated With Insulin
Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Hyperglycemia affects 30-40% of hospitalized patients. Despite the fact that basal/bolus insulin therapy has been demonstrated to improve glycemic control and clinical outcomes in patients, achieving good glucose control remains…
- Trial name
- In-FI (NCT04460326)
- Testing
- Insulin glargine, NovoLog, Insulin Fiasp
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Boston Medical Center
Maximum Observed Plasma Glucose Concentration (Cmax)
Processed Orange and the Glycemic Response
Randomized, placebo controlled, double blind, postprandial crossover study in male subjects. 3 intervention arms, consisting of a control (Product A), a low dose processed whole orange (Product B) and a high dose processed whole…
- Trial name
- POGR (NCT02112851)
- Testing
- Orange flavored beverage
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Glycemic Control
Effects of Stair Stepping on Late Day Postprandial Glycemia
1. Purpose/objective: The purpose of the current study is to investigate whether the benefits of stair stepping established for early day food consumption extend to late day food consumption. 2.
- Trial name
- NCT05617157
- Testing
- Stair stepping
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Glycemic Control
Glycemic Response in Adults With Type 2 Diabetes
This is a randomized, controlled, crossover study to compare the effects of two treatments on postprandial glucose in adults with type 2 diabetes.
- Trial name
- NCT05166200
- Testing
- Experimental Formula, Test Meal
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Abbott Nutrition
Hyperglycemia, Carbohydrate
Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption
This project will test a unique botanical formula designed to inhibit alpha amylase (the primary starch degrading digestive enzyme) and inhibit sucrase (the primary sucrose degrading digestive enzyme) in order to reduce acute…
- Conditions
- Hyperglycemia, Carbohydrate, Insulin Resistance, Malabsorption
- Trial name
- PBPPCG (NCT03897517)
- Testing
- Proprietary Botanical Blend
- Volunteers
- 30 people
- Sponsor
- Plexus Worldwide
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Modification
A Trial on the GI of Spaghetti Versus Rice as Mixed Meals
Pasta and rice are two of the most commonly consumed grains worldwide, where the former has a low GI (e.g. spaghetti) and the latter, usually (as it depends on the type) has a higher GI (e.g. white rice).
- Trial name
- NCT03104712
- Testing
- Glucose #1, Glucose #2, Glucose #3
- Where
- Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Parma
Blood Sugar
Comparison of the Postprandial Glycemic and Insulinemic Response of ALLSWEET When Taken Alone or When Added to Sucrose
This study will explore the postprandial glycemic response of ALLSWEET®, a non-GMO certified allulose, when consumed alone or with sucrose, compared to the consuming sucrose alone.
- Trial name
- NCT05185960
- Testing
- ALLSWEET®, ALLSWEET® and sucrose, Sucrose
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Diabetes Mellitus
A Study to Evaluate the Effect of Nasal Insulin on Postprandial Glycemic Control in Type 2 Diabetic Patients
Insulin is a hormone which is produced by the human pancreas for the lowering of blood sugar. In patients who don't produce enough insulin, additional insulin must be given several times per day by injections.
- Trial name
- NCT00624767
- Testing
- Insulin (recombinant human insulin), NovoLog
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Nastech Pharmaceutical Company, Inc.
Diabetes, Diabetes Type 2
ACUTE EFFECT OF CONSUMPTION OF GROUND OR WHOLE FLAXSEEDS ON BLOOD GLUCOSE IN PEOPLE WITH TYPE 2 DIABETES
This study aimed to evaluate the effect of consuming a portion of French bread combined with whole or ground flaxseed on the glycemia of people with DM 2 in a randomized, crossover clinical trial conducted with 16 people with DM…
- Conditions
- Diabetes, Diabetes Type 2, Insulin Resistance
- Trial name
- DM2 (NCT06912542)
- Testing
- Whole flaxseed bread, Ground flaxseed bread, French bread
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Universidade Francisca
Glycemic Control, Diabetes Mellitus Risk
Effects of Seaweed Extract on Postprandial Response to White Bread
The study is designed to determine whether seaweed extract added to a carbohydrate-rich meal, can lower blood glucose levels after its consumption, and hence lower its glycaemic index, and if this effect is mediated through…
- Conditions
- Glycemic Control, Diabetes Mellitus Risk, Glucose Intolerance, Postprandial Hyperglycemia
- Trial name
- NCT05460884
- Testing
- Seaweed extract LD and white bread, Seaweed extract HD and white bread, White bread
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Diabetes Mellitus, Type 2
Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes
The primary objective of this study is to show that a prandial insulin regimen, consisting of premeal insulin lispro "mid mixture" (or a combined regimen of insulin lispro "mid mixture" and insulin lispro "low mixture") plus…
- Trial name
- NCT00191464
- Testing
- premeal insulin lispro mixtures, insulin glargine, metformin
- Where
- 7 sites in United States, Australia and 5 more
- Volunteers
- 320 people
- Sponsor
- Eli Lilly and Company