Clinical trials: Postprandial Hyperglycemia
Type 1 Diabetes, Type 1 Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Hyperglycemia, Postprandial
- Trial name
- NCT04163874
- Testing
- Fiasp, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University
Postprandial Hyperglycemia
Bread Structure and Postprandial Metabolic Responses
The structural properties of bread are considered one of the most important factors that can affect its digestibility, glucose homeostasis and postprandial metabolic responses.
- Trial name
- NCT05691686
- Testing
- Finely milled whole wheat-legume bread, Less processed whole wheat-legume bread, Less processed whole wheat bread
- Where
- Greece
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Postprandial Hyperglycemia, Hyperinsulinemia
Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults
Diabetes and cardiovascular disease account for millions of deaths per year. One of the risk factors for both conditions is high blood sugar, particularly after eating (postprandial hyperglycaemia).
- Trial name
- SURE-BloG (NCT06714552)
- Testing
- Galacto-Oligosaccharide, Glucose
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial
Exercise-meal Timing and Postprandial Glucose Control
Physical activity helps maintain optimal postprandial blood glucose control. However, there is a lack of clear information regarding the optimal meal-activity timing required to maximize blood glucose control.
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial, Physical Activity, Glucose Intolerance
- Trial name
- NCT03730727
- Testing
- Physical activity, Meal
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Impaired Glucose Tolerance
Postprandial Fatty Acid Metabolism in the Natural History of Type 2 Diabetes (T2D)
Lipotoxicity-causing fatty acid overexposure and accretion in lean tissues leads to insulin resistance and impaired pancreatic β-cell function - the hallmarks of T2D - contributing to associated complications such as heart…
- Trial name
- AGL11 (NCT02808182)
- Testing
- Nicotinic acid, [7,7,8,8-2H]-palmitate, [U-13C]-palmitate
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Post-Prandial Hyperglycemia, Post-Prandial Hypoglycemia
Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy
The study will be conducted in two phases; an in-patient meal study phase (Phase I) and an outpatient home study (Phase II). The two phase study design is chosen to enhance safety by testing the Afrezza Closed-Loop (CL) system in…
- Trial name
- NCT03234491
- Testing
- DiAS, Afrezza low dose, Afrezza high dose
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Postprandial Hyperglycemia
Metabolic Effects of High-amylose Wheat-based Breads
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial…
- Trial name
- NCT03899974
- Testing
- Test meal
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Endothelial Dysfunction
The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
- Trial name
- WMJ (NCT04092439)
- Testing
- Watermelon Juice
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus Type 1
Comparison of the Management of Post-prandial Hyperglycemia by Multiple Bolus Calculators
This prospective, non-randomized, non-controlled, interventional study will determine whether the Roche automated bolus caclulator (ABC) reduces post-meal hyperglycemia better than the competitor's ABC without causing significant…
- Trial name
- NCT01050868
- Testing
- Accu-Chek Combo Kit mg DE/de
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
Type2 Diabetes, Postprandial Hyperglycemia
Postprandial Metabolites of Meal Challenge Test in Diabetes State
Postprandial hyperglycemia is a hallmark feature of Type 2 Diabetes Mellitus (T2D), and persistent elevated glycemic level has shown to be strongly associated with oxidative stress, and a risk factor for cardiovascular disease…
- Trial name
- NCT04234763
- Testing
- Strategies to lower postprandial hyperglycemia in T2D patients, Control group
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Putra Malaysia
Healthy Diet, Postprandial Hyperglycemia
Effect of the Consumption of Alcohol-free Beers With Different Carbohydrates Composition on Postprandial Metabolic Response
The overall objective of this study is to explore the glycemic index and glycemic load induced by an alcohol-free beer with modified composition (including almost full fermentation of carbohydrates and the addition of…
- Trial name
- NCT04790877
- Testing
- Sub-study 1, Sub-study 2
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Type 1 Diabetes
Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy
"Closed loop artificial pancreas" systems have been under development for the control of blood sugars in those living with diabetes.
- Trial name
- NCT01945099
- Testing
- ePID closed loop system, hyaluronidase, Lispro-PH20
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Oral Glucose Tolerance Test, High Fat Tolerance Test
Effects of Fluid Milk in Attenuating Hyperglycemia and Hypertriglyceridemia After Meal
Epidemiological studies indicate that risk of type 2 diabetes is lower when milk is consumed in the regular diet. Milk products are unique in that they produce high insulin response despite their low glycemic index.
- Trial name
- NCT02894112
- Testing
- non-fat milk, carbohydrate control beverage, caloric control beverage
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Impaired Glucose Tolerance
The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes
The purpose of this study is to compare the effects of exenatide versus metformin on vascular health with chronic (3-month) therapy and during a 2-hour period following a meal in patients with pre-diabetes.
- Trial name
- NCT00546728
- Testing
- Exenatide, Metformin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Paul Heart Clinic
Type 2 Diabetes, Glycemic Control
Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose
Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes.
- Trial name
- NCT00821665
- Testing
- Sucrose consumption, water consumption
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes Mellitus, Postprandial Hyperglycemia
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.
- Trial name
- NCT00771693
- Testing
- Insulin aspart (Novorapid®)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2
A Study of Postprandial Hyperglycemia in Participants With Type 2 Diabetes
This Study is looking at whether high blood glucose levels after a meal affect arterial stiffness more or less than low blood glucose levels, and whether certain cardiovascular markers influence the outcome of this.
- Trial name
- NCT01159938
- Testing
- Lispro
- Where
- Finland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pre Diabetes, Postprandial Hyperglycemia
Evaluating the Acute Glycemic Response to Different Strategies of Breaking Up Sedentary Time
This study aims to determine the most effective strategy of reducing sedentary behavior to improve health. Specifically, we aim to answer the following questions: (a) To determine if there is a significant difference in acute…
- Trial name
- NCT04144920
- Testing
- CS: Continuous sitting, HFLD: HIgh frequency, low duration standing breaks, LFHD: Low frequency, high duration standing breaks
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Arizona State University
Breakfast
Eating vs Skipping Breakfast on Postprandial Hyperglycemia After Lunch and Dinner in T2D
Background: Skipping breakfast and/or overeating at evening, has been associated in type 2 diabetic (T2D) individuals, with higher BMI, visceral adiposity, hyperlipidemia, increased overall postprandial glycemia (PPHG) and higher…
- Trial name
- SkippB-T2D (NCT02287103)
- Testing
- Skipping Breakfast, Eating Breakfast
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel Aviv University