Clinical trials: Posttraumatic Stress
Nightmares, Insomnia
Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
Exposure to trauma, especially when it manifests as Posttraumatic Stress Disorder (PTSD), results in numerous negative consequences for patients, families, and society.
- Conditions
- Nightmares, Insomnia, Posttraumatic Stress Disorder
- Trial name
- NCT01009112
- Testing
- PTSD + IRT/CBT-I, PTSD + Supportive Care Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Diego
Posttraumatic Stress Disorder, Pregnancy Related
Online Intervention to Promote Resilience to Traumatic Stress During Pregnancy
The investigators will design, construct, and pilot a prototype of a trauma-informed online intervention, which will be called "SunnysideFlex," that functionally integrates a web-based intervention targeting skills to decrease…
- Trial name
- NCT04992767
- Testing
- Sunnyside, SunnysideFlex
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Post-Traumatic Stress Disorder
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
- Trial name
- NCT00158262
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder
Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
This study proposes to evaluate the effects of D-cycloserine (DCS) combined with cognitive-behavioral treatment with exposure therapy in a sample of patients who developed posttraumatic stress disorder (PTSD) as a consequence of…
- Trial name
- NCT00875342
- Testing
- DCS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Posttraumatic Stress Disorders
Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function
The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.
- Trial name
- NCT01644851
- Testing
- Executive function training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Posttraumatic Stress Disorders
Cognitive Behavioral Therapy to Improve Work and Wellness in Veterans With Mental Illness
Vocational instability in Veterans with serious mental illness (SMI) is pervasive, costly, and harmful. Over 75% of Veterans with SMI are unemployed, resulting in economic difficulties and trouble meeting basic needs.
- Trial name
- WORKWELL (NCT04504903)
- Testing
- Cognitive Behavioral Therapy For Work Success (CBTw), Psychoeducation
- Where
- 3 sites in United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Investigating a Novel Sensory-based Program for Veterans With PTSD
SENSE-PTSD is an randomized controlled trial (RCT) which will evaluate the feasibility and efficacy of a novel, sensory-based psychoeducational program for improving psychological, functional, sensory, and cognitive outcomes in…
- Trial name
- SENSE-PTSD (NCT05766241)
- Testing
- Sensory Strategies Training
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- McMaster University
Posttraumatic Stress Disorder With Attention Defic
Atomoxetine and Executive Function in PTSD
Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes.
- Trial name
- NCT06573970
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Shame
NET for SGBV Survivors in Eastern DR Congo
Throughout the last 10 years Narrative Exposure Therapy (NET) has evolved as one of the most effective, culturally sensitive trauma interventions.
- Trial name
- NCT02989987
- Testing
- Narrative Exposure Therapy, Social Support
- Where
- Germany
- Volunteers
- 201 people
- Sponsor
- University of Konstanz
Posttraumatic Stress Disorder
GAMBIT Task With PTSD and Healthy Control Participants
This is a pilot study of a digital training task called GAMBIT. This study will be the first to examine potential relationships between GAMBIT task completion and brain circuit flexibility, behavior, and symptoms in participants…
- Trial name
- GAMBIT (NCT05313334)
- Testing
- GAMBIT Task
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder (PTSD), Suicidal Ideation
Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD
The purpose of this research is to see if Crisis Response Planning (CRP), a brief strategy designed to help people cope effectively with emotional crises, combined with Cognitive Processing Therapy (CPT), a talk treatment for…
- Conditions
- Posttraumatic Stress Disorder (PTSD), Suicidal Ideation, Suicide Attempt
- Trial name
- mCPT+CRP (NCT07238192)
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Ohio State University
Alcohol Use, Posttraumatic Stress Disorder
CBT vs. Supportive Texts for PTSD & Hazardous Drinking (Project Better Study 2)
The study aims to test the efficacy of a CBT-enhanced text message intervention and a supportive text message intervention to reduce symptom burden in individuals with post-traumatic stress disorder symptoms and co-occurring…
- Trial name
- NCT06648395
- Testing
- CBT Text Messages, Supportive Messages
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- University of Washington
Substance Use Disorders, Posttraumatic Stress Symptom
Safe & Sound Protocol in Adults With Trauma and SUD
This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma.
- Conditions
- Substance Use Disorders, Posttraumatic Stress Symptom, Anxiety
- Trial name
- NCT07219056
- Testing
- Safe and Sound Protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Caron Treatment Centers
Stress Disorders, Posttraumatic, PTSD
Neural Correlates of PTSD Prevention With Mindfulness Based Stress Reduction (MBSR) in Iraqi Veterans
The purpose of this study is to compare Mindfulness Based Stress Reduction to a supportive therapy control group.
- Trial name
- NCT01058031
- Testing
- MBSR
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder, Pseudopheochromocytoma
Clinical Autonomic Disorders: A Training Protocol
Background: The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia.
- Conditions
- Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope
- Trial name
- NCT02154009
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Insomnia, Posttraumatic Stress Disorder
Suvorexant and Trauma Related Insomnia
Problems sleeping are common after exposure to highly threatening experiences and can occur with and without a diagnosis of posttraumatic stress disorder (PTSD).
- Trial name
- NCT02704754
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Howard University
Posttraumatic Stress Disorder
A Controlled Breathing Course for Social & Emotional Health for Vietnam Veterans With Chronic PTSD-RCT
The main aim of this project is to evaluate the use of a specific Yoga technique of controlled breathing in Vietnam War Veterans with chronic posttraumatic stress disorder.
- Trial name
- NCT00256477
- Testing
- Sudarshan KRIYA Breathing Technique
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Impulsive Aggression, Posttraumatic Stress Disorder
Pilot Trial of Neural Correlates of Response to Treatment of PTSD-Associated Impulsive Aggression
The purpose of this study is to identify changes in brain functioning which are related to reduced frequency and/or intensity of impulsive aggressive actions after treatment of PTSD-related impulsive aggression with either…
- Trial name
- NCT00333931
- Testing
- Phenytoin, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Posttraumatic Stress Disorder
Trial of Mifepristone in Combat Veterans With Posttraumatic Stress Disorder
The investigators propose to conduct a randomized double-blind, parallel-group, placebo-controlled trial of mifepristone in veterans with military-related posttraumatic stress disorder (PTSD).
- Trial name
- NCT00833339
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
PTSD, Anxiety Disorders
Creating Resilient Workplaces Study
The proposed study aims to understand the impact of a 5-Class CBTm Course on variables contributing to workplace resilience among Public Safety Personnel (PSP).
- Conditions
- PTSD, Anxiety Disorders, Depression, Stress Disorders, Posttraumatic
- Trial name
- CReW (NCT04002050)
- Testing
- Cognitive Behavioural Therapy with Mindfulness Course
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba