Clinical trials: Posttraumatic Stress, active
mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Mindful RAVANS Study
This pilot study is testing a new treatment for people who still have frequent headaches months after a mild traumatic brain injury, with about half of the participants coming from military or veteran backgrounds.
- Conditions
- mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Headache
- Trial name
- RAVANS (NCT07872761)
- Testing
- Cala-RAVANS (Model CR-2)
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Posttraumatic Stress Disorder
Neurobiology of Posttraumatic Stress Disorder Dysfunction and Recovery Following Cognitive Processing Therapy
Posttraumatic stress disorder (PTSD) is a significant personal and societal burden. The purpose of this study is to examine genetic, epigenetic, behavioral, and brain activity changes related to PTSD dysfunction and recovery…
- Trial name
- NCT02695953
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Milissa Kaufman
Post Traumatic Stress Disorder, Trauma
Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD
This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older.
- Trial name
- NCT07485231
- Testing
- Beetroot Juice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Posttraumatic Stress Disorders, Dissociative Identity Disorder
Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect
This study aims to evaluate the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women who have histories of childhood abuse and neglect.
- Trial name
- NCT02757339
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms
Veterans with co-morbid posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) are at substantial risk of developing hypertension and cardiovascular diseases that often lead to premature death, with some evidence…
- Trial name
- NCT07756723
- Testing
- Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Coatesville VA Medical Center
Posttraumatic Stress Disorder
The Predictive Role of Immune-inflammatory Biomarkers and Their Interaction With the Oxytocin System in Trauma-related Psychotherapy Responsiveness
Despite a range of treatments for posttraumatic stress disorder (PTSD), only a small proportion of patients reach full symptomatic remission.
- Trial name
- NCT06348472
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Shalvata Mental Health Center
Posttraumatic Stress Disorder (PTSD)
EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder
Posttraumatic stress disorder, or PTSD, can affect emotional health, sleep, daily functioning, and quality of life. Written Exposure Therapy is a brief trauma-focused psychotherapy in which participants complete structured…
- Trial name
- TREAT (NCT07766798)
- Testing
- Written Exposure Therapy, Neutral Writing Condition
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mclean Hospital
PTSD, Posttraumatic Stress Disorder
Repurposing Low-Dose Clonidine for PTSD in Veterans
Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors.
- Conditions
- PTSD, Posttraumatic Stress Disorder, Sleep
- Trial name
- NCT04877093
- Testing
- Clonidine Pill
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Posttraumatic Stress Disorder
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral…
- Trial name
- MAGNETS (NCT06449326)
- Testing
- Active Intermittent theta burst stimulation
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of New Mexico
Posttraumatic Stress Disorder (PTSD)
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)
This study is testing a personalized form of brain stimulation called PrTMS as a treatment for post-traumatic stress disorder (PTSD) in military service members and veterans.
- Trial name
- NCT07526285
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial
The purpose of the current research study is to evaluate the efficacy of the refined Written Exposure in Substance Treatment (WEST) for PTSD among residential SUD patients through a randomized controlled trial.
- Trial name
- WEST (NCT07782268)
- Testing
- Written Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Potomac Health Foundations
Trauma, Posttraumatic Stress Disorder
Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)
One of the most common and widely disseminated trauma treatments is Trauma Focused Cognitive Behavioral Therapy (TF-CBT). TF-CBT is a therapist-led, structured and sequential intervention, with treatment organized around…
- Trial name
- NCT07396935
- Testing
- Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Posttraumatic Stress Symptoms, Burnout
FLOAT for Healthcare PTSS
This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and…
- Conditions
- Posttraumatic Stress Symptoms, Burnout, Burnout, Healthcare Workers, First Responders
- Trial name
- PTSS FLOAT (NCT07710417)
- Testing
- Floatation-REST, Documentary
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Stress Disorders, Post-Traumatic, Pain, Chronic
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain
Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions…
- Trial name
- NCT07725588
- Testing
- Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
SEE FAR CBT Intervention for Adults With PTSD
This single-arm clinical intervention study evaluates a 12-session SEE FAR CBT intervention for adults aged 18 years and older with posttraumatic stress disorder (PTSD).
- Trial name
- NCT07720674
- Testing
- SEE FAR CBT
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Community Stress Prevention Center
Generalized Anxiety Disorder, Social Anxiety Disorder
Metacognitive Therapy Compared to Cognitive-behavioral Therapy
This is a qualitative study of participants who have taken part in a randomized controlled trial comparing transdiagnostic metacognitive therapy and disorder-specific cognitive-behavioral therapy for anxiety disorders.
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Posttraumatic Stress Disorder (PTSD)
- Trial name
- NCT07382323
- Testing
- Transdiagnostic metacognitive therapy, Disorder-specific cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
PTSD, Posttraumatic Stress Disorder
Biomarkers in the Retina for Prognosticating Mental Health Treatments
Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event.
- Trial name
- BRIGHT (NCT06363968)
- Testing
- RETeval
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Puget Sound Health Care System
Posttraumatic Stress Disorder
A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD
Posttraumatic Stress Disorder (PTSD) remains a salient and debilitating problem, in the general population and for military veterans in particular.
- Trial name
- NCT04961190
- Testing
- Prolonged Exposure Therapy, Pharmacotherapy with paroxetine or venlafaxine XR
- Where
- 7 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Postpartum Complication, Posttraumatic Stress Symptoms
Labor Education to Reduce Postpartum Traumatic Stress
The goal of this randomized controlled trial is determine if education on common events in labor in nulliparous women can reduce the postpartum traumatic symptoms.
- Trial name
- LEPT (NCT06992791)
- Testing
- Prenatal Education on Childbirth
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Posttraumatic Stress Disorder (PTSD), Intrinsic and Novelty-related Sensory Cortical (SC) Disinhibition
A Neurosensory Account of Anxiety and Stress (Study 1)
This study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD. Additionally, the study aims to identify how Transcranial Alternating Current Stimulation (tACS) brain stimulation can…
- Trial name
- NCT05895006
- Testing
- Alternating Current Stimulation (tACS), Transcranial Random Noise stimulation (tRNS)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston