Clinical trials: Posttraumatic Stress Disorder
Posttraumatic Stress Disorder, Insomnia Disorder
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
This study will investigate treatments for insomnia in Veterans who have posttraumatic stress disorder (PTSD). The purpose of this study is to compare a brief behavioral treatment for insomnia (BBTI) to a treatment that helps…
- Trial name
- BBTI & PTSD (NCT05780177)
- Testing
- Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Inflammation
Probiotic (LGG) for Veterans With PTSD
Exaggerated inflammation in the body and brain is thought to play a role in the vulnerability to and aggravation and perpetuation of adverse consequences among those with posttraumatic stress disorder (PTSD).
- Trial name
- NCT04150380
- Testing
- Lactobacillus rhamnosus GG (LGG; ATCC strain 53103; CRMTS #11272; PTS #3766)
- Where
- United States
- Volunteers
- 383 people
- Sponsor
- VA Eastern Colorado Health Care System
Posttraumatic Stress Disorder
Gaze-Contingent Music Reward Treatment for PTSD
The present study is a double-blind trial that seeks to examine the feasibility, acceptability, and efficacy of a recently developed eye-tracking-based, gaze-contingent music reward therapy (GC-MRT) in individuals with…
- Trial name
- NCT05057624
- Testing
- GC-MRT, Exposure
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post-Traumatic Stress Disorder
Therapeutic Effects of the Processing of Positive Memories Technique on Posttrauma Health
The current study will examine daily-level impacts of a technique addressing positive memory retrieval on thoughts, feelings, and health among individuals with trauma experiences.
- Trial name
- PPMT (NCT06680193)
- Testing
- Processing of Positive Memories Technique
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Texas, Denton, TX
To Investigate the Incidence and Causes of Awareness During General Anesthesia, To Investigate the of Dreaming During Anesthesia
İntraoperative Awareness Under General Anesthesia
Intraoperative awareness which means the recall of experiences recorded in patients' memories during general anesthesia in the postoperative period is an important issue in anesthesia practice.
- Conditions
- To Investigate the Incidence and Causes of Awareness During General Anesthesia, To Investigate the of Dreaming During Anesthesia, To Investigate the Intra-operative Experiences of Patients Who Report Awareness, To Investigate the Risk Factors That May be Associated With Awareness
- Trial name
- NCT04697732
- Testing
- General anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 30,000 people
- Sponsor
- Baskent University Ankara Hospital
PTSD
Post-Traumatic Stress Disorder (PTSD) Symptom Study
The primary goals for this investigation are to quantify: (1) fluctuations in PTSD symptom reports when assessed at bi-weekly intervals; (2) change in PTSD symptoms associated with stressful life events; and (3) change in PTSD…
- Trial name
- NCT00018798
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Comparing Imaginal Exposure and Imagery Rescripting in Treatment of Posttraumatic Stress Disorder (PTSD)
The outcome of trauma treatment (Posttraumatic Stress Disorder - PTSD) may be influenced by which emotions that are predominant among current symptoms, e.g. fear, anger, guilt, shame.
- Trial name
- NCT00891098
- Testing
- Imaginal exposure, Imagery rescripting
- Where
- Norway
- Volunteers
- 65 people
- Sponsor
- Modum Bad
Traumatic Brain Injury, Post Traumatic Stress Disorder
Executive Dysfunction and Self-Harm Behavior: An Examination of Veterans With TBI, PTSD, or Both
1. To determine whether tasks taken from the field of cognitive neuroscience can detect and distinguish impairments in executive function above and beyond standard neuropsychological measures in individuals with: a.) Mild…
- Conditions
- Traumatic Brain Injury, Post Traumatic Stress Disorder, Suicide, Self-Injurious Behavior
- Trial name
- NCT01334463
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Posttraumatic Stress Disorder (PTSD)
Trauma Suppression Training for Veterans
Intrusive memories of trauma are a core and often persistent symptom of posttraumatic stress disorder (PTSD). This study tested whether veterans with PTSD could take part in a computer-based training program that teaches people…
- Trial name
- TSTV (NCT07891559)
- Testing
- Web-based Think/No-Think retrieval-suppression training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Palo Alto Veterans Institute for Research
Stress Disorders, Post-Traumatic, Alcoholism
The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD
This study will investigate the effects of oxytocin on alcohol-related behaviors, social abilities, and physiological startle responses in healthy individuals and patients with posttraumatic stress disorder (PTSD) and alcohol use…
- Trial name
- POP (NCT02469259)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD)
- Trial name
- STRIDES2 (NCT06923423)
- Testing
- Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
- Where
- 6 sites in United States
- Volunteers
- 640 people
- Sponsor
- University of Arkansas
Posttraumatic Stress Disorder, Depression
Efficacy of Narrative Exposure Therapy (NET) in Treating Women After Human Trafficking or Forced Prostitution
The purpose of this study is to perform an evaluation of a trauma-focused short-term intervention (Narrative Exposure Therapy; Schauer, M., Neuner, F.
- Conditions
- Posttraumatic Stress Disorder, Depression, Dissociation
- Trial name
- NCT00717548
- Testing
- Narrative Exposure Therapy
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Konstanz
Posttraumatic Stress Disorder, Traumatic Brain Injury
Cognitive REmediation After Trauma Exposure Trial = CREATE Trial
This study will evaluate the efficacy of methylphenidate and galantamine in the treatment of persistent cognitive symptoms associated with posttraumatic stress disorder (PTSD) and/or traumatic brain injury (TBI).
- Trial name
- CREATE (NCT01416948)
- Testing
- Methylphenidate Hydrochloride 20 mg, Galantamine 12 mg
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Stress Disorders, Post-Traumatic
A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)
To evaluate the safety, efficacy and tolerability of brexpiprazole (with placebo) as monotherapy or combination therapy with Zoloft (sertraline) in adults with PTSD.
- Trial name
- NCT03033069
- Testing
- Brexpiprazole, Sertraline
- Where
- 54 sites in United States
- Volunteers
- 336 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Post Traumatic Stress Disorder
An Internet-delivered Cognitive-behavioral Intervention Provided Soon After Trauma: a RCT
The primary objective with this study is to investigate the short-term efficacy (primary endpoint at week 3) of Internet-delivered cognitive behavior therapy (ICBT) provided soon after trauma.
- Trial name
- NCT04101942
- Testing
- Internet-based CBT
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Karolinska Institutet
Post Traumatic Stress Disorder
A Study of JZP150 in Adults With Posttraumatic Stress Disorder
This is a 12-week, double-blind, placebo-controlled, randomized, parallel-group, multicenter study of the safety and efficacy of JZP150 in the treatment of adult participants with post-traumatic stress disorder (PTSD).
- Trial name
- NCT05178316
- Testing
- JZP150
- Where
- 52 sites in United States
- Volunteers
- 282 people
- Sponsor
- Jazz Pharmaceuticals
Depression, Posttraumatic Stress Disorder
Effectiveness of Group Focused Psychosocial Support for Adults Affected by Humanitarian Crises
This is an effectiveness study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises.
- Conditions
- Depression, Posttraumatic Stress Disorder, Psychological Distress
- Trial name
- GroupPM+ (NCT03747055)
- Testing
- Group problem management plus, Enhanced treatment as usual
- Where
- Nepal
- Volunteers
- 611 people
- Sponsor
- George Washington University
Gunshot Entry Wound
Predictors of Treatment Failure Among Patients With Gunshot Wounds and Post-traumatic Stress Disorder
The 82.1% treatment failure of post-traumatic stress disorder(PTSD), associated with gunshot wounds, is related to high incidence of chronic pain syndrome as well as resistance to the PTSD treatment.
- Trial name
- NCT04689022
- Testing
- Mississippi Scale for Combat-Related PTSD (M-PTSD), visual analogue scale (VAS), Douleur Neuropathique 4 questions (DN4)
- Volunteers
- 218 people
- Sponsor
- Vasyl' Horoshko
Post Traumatic Stress Disorder, Postoperative Complications
PTSD of Surgeons or Anesthesiologists on Prognosis of Surgical Patients
The objective of this prospective cohort study is to explore the association between the development of post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists and postoperative prognosis in surgical patients they…
- Conditions
- Post Traumatic Stress Disorder, Postoperative Complications, COVID-19
- Trial name
- NCT05732116
- Testing
- PTSD
- Where
- 2 sites in China
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Alcohol Abuse, Post-Traumatic Stress Disorder
Pilot Evaluation of the VetChange Mobile App for Veterans With PTSD Who Engage in Problem Drinking
Concept: Alcohol misuse is common among Veterans with PTSD. It has been proposed that this high comorbidity is the result of "self-medication," with alcohol being used to alleviate common PTSD symptoms (e.g., hyperarousal, sleep…
- Trial name
- NCT03208738
- Testing
- VetChange, web-based drinking assessment and feedback tool (AFT)
- Volunteers
- 280 people
- Sponsor
- Eric Kuhn