Clinical trials: Posttraumatic Stress Disorder
PTSD
A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective at reducing PTSD symptoms in people with PTSD who received placebo in a prior MDMA-assisted therapy study.
- Trial name
- MAPPUSX (NCT04714359)
- Testing
- Midomafetamine HCl
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 87 people
- Sponsor
- Resilient Pharmaceuticals
Post-Traumatic Stress Disorder
Comparison of Two Treatments for Post-Traumatic Stress Disorder
This study will compare the short- and long-term effectiveness of two different treatments for people with post-traumatic stress disorder.
- Trial name
- NCT00127673
- Testing
- Sertraline, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Post Traumatic Stress Disorder
Expressing Personal Recollections in English or Spanish to Alleviate Traumatic Emotions (Exprésate)
The purpose of this study is to test if expressive writing about traumatic events has positive changes in women living with post-traumatic stress.
- Trial name
- Exprésate (NCT05090839)
- Testing
- Weekly Emotional Disclosure (WED), Weekly Emotional Disclosure (WED) Spanish
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Posttraumatic Stress Disorder
A Self-Management Program for Completers of Trauma-Focused Therapy for PTSD
Veterans who complete trauma-focused therapies (TFTs) report improvements in posttraumatic stress disorder symptoms, quality of life, and social and role functioning.
- Trial name
- EMPOwER (NCT03225859)
- Testing
- Self-Management Program
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
The scientific objective of this program is to meet the rehabilitation needs of combat wounded Veterans with mild to moderate Traumatic Brain Injury (TBI) via telerehabilitation and determine the effect of this modality of care…
- Trial name
- NCT00676182
- Testing
- Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Post-Traumatic Stress Disorder
A Study To Assess the Effects Of PF-04457845 On BOLD fMRI In Subjects With Post Traumatic Stress Disorder
The purpose of the study is to evaluate proof of mechanism of PF-04457845, using a well-established neuroimaging paradigm including behavioral tasks selected to activate neuro-circuitry relevant to Post Traumatic Stress Disorder.
- Trial name
- NCT02216097
- Testing
- PF-04457845
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Pfizer
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Post Traumatic Stress Disorder
Service Dog Training Program for Military Veterans With PTSD
Post-traumatic stress disorder (PTSD), an invisible wound of war, affects approximately 20%1 of the 18.5 million U.S. veterans and places them at higher risk for impaired biopsychosocial functioning.
- Trial name
- NCT03777020
- Testing
- Service Dog Training Program, Dog Training Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Posttraumatic Stress Disorder, Major Depressive Disorder
rTMS for PTSD Comorbid With Major Depressive Disorder
The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive
- Trial name
- NCT02273063
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Post-Traumatic Stress Disorder
A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder
This study is open to people aged 18 to 65 who have post-traumatic stress disorder. The purpose of this study is to find out whether a medicine called BI 1358894 improves symptoms in people with post-traumatic stress disorder.
- Trial name
- NCT05103657
- Testing
- BI 1358894
- Where
- 61 sites in United States, Croatia and 6 more
- Volunteers
- 318 people
- Sponsor
- Boehringer Ingelheim
Posttraumatic Stress Disorder (PTSD)
The Impact of Vocational Rehabilitation on Mentally III Veterans
To study the impact of Individual Placement and Support (IPS) supported employment (SE) compared to treatment-as-usual vocational rehabilitation program (VRP) for veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT00333801
- Testing
- Vocational Rehabilitation Program (VRP), Individual Placement and Support (IPS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Autism, Trauma
A Pilot Participatory Program Evaluation of a Virtual Trauma Support Program for Autistic Adults
The goal of this single-group clinical trial is to learn about the initial efficacy and feasibility of telehealth-delivered Written Exposure Therapy (WET) for autistic adults with traumatic stress symptoms.
- Conditions
- Autism, Trauma, Posttraumatic Stress Disorder, Posttraumatic Stress Symptom
- Trial name
- NCT05862467
- Testing
- Written Exposure Therapy (WET) via telehealth
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wyoming
Guilt, Shame
Trauma Informed Guilt Reduction Therapy
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt.
- Conditions
- Guilt, Shame, Post-traumatic Stress Disorders
- Trial name
- TrIGR (NCT02512445)
- Testing
- Trauma Informed Guilt Reduction Therapy, Supportive Care Therapy
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Veterans Medical Research Foundation
Posttraumatic Stress Disorder
Placebo Controled Clinical Trial Using Topiramate To Treat Posttraumatic Stress Disorder (PTSD) Patients.
The study is 12-week randomized placebo controlled trial compared to topiramate to treat patients with posttraumatic stress disorder, according to DSM-IV criteria.
- Trial name
- NCT00725920
- Testing
- Topiramate
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Federal University of São Paulo
Posttraumatic Stress Disorder
Cognitive Training for PTSD
Posttraumatic stress disorder (PTSD) is a chronic, disabling condition that occurs in a subgroup of individuals after experiencing traumatic stress, and is common in Veterans seeking mental health treatment at the VA.
- Trial name
- NCT03316196
- Testing
- COGENT COGNITIVE TRAINING, Non training computer condition
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Alcohol-related Disorders, Post-traumatic Stress Disorder
Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder
The purpose of this study is to develop and test a couple-based treatment for Veterans with an alcohol use disorder and post-traumatic stress disorder.
- Trial name
- CTAP (NCT00946322)
- Testing
- Couple-Based Treatment for Alcohol Use Disorders and PTSD
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
This study proposes to evaluate the effects of D-cycloserine (DCS) combined with cognitive-behavioral treatment with exposure therapy in a sample of patients who developed posttraumatic stress disorder (PTSD) as a consequence of…
- Trial name
- NCT00875342
- Testing
- DCS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Sleep Disorders, PTSD
Efficacy of a Brief Nightmare Treatment for Veterans
The purpose of this study is to find out what effects Exposure, Rescripting, and Relaxation Therapy (ERRT) has on nightmares and associated problems in veterans.
- Conditions
- Sleep Disorders, PTSD, Suicide
- Trial name
- NCT01220401
- Testing
- exposure, relaxation, and rescription therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Tulsa
Posttraumatic Stress Disorder
A Multisite Randomized Controlled Trial of Mindfulness Meditation Therapy for PTSD
Currently, veterans with posttraumatic stress disorder (PTSD) are typically treated with antidepressants which have limited efficacy and yield extremely low remission rates.
- Trial name
- NCT01532999
- Testing
- Mindfulness Based Stress Reduction, Present Centered Group Therapy
- Where
- 3 sites in United States
- Volunteers
- 254 people
- Sponsor
- US Department of Veterans Affairs