Clinical trials: Posttraumatic Stress Disorder
Psychosis;Schizophrenic, Personality Disorders
The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology
The outbreak of the SARS-CoV-2 pandemic may be considered a traumatic phenomenon. In a sample of subjects suffering from different psychiatric disorders, psychopathological status and Post-Traumatic Stress Disorder (PTSD)…
- Conditions
- Psychosis;Schizophrenic, Personality Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT04694482
- Testing
- Psychometric scale administration
- Where
- Italy
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Post-Traumatic Stress Disorder
Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine
The proposed study has three distinct but related research objectives. The first goal is to measure physiological correlates of successful treatment with Prolonged Exposure (PE) therapy for posttraumatic stress disorder (PTSD) in…
- Trial name
- NCT01031979
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder, Depressive Disorder
Project SERVE: Post Deployment Functioning
Functional recovery is of the utmost importance to evaluate in our returning Operation Enduring and Iraqi Freedom Veterans so that we can better understand their needs and experiences during the readjustment process from warzone…
- Conditions
- Post-traumatic Stress Disorder, Depressive Disorder, Alcoholism
- Trial name
- NCT01123642
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Posttraumatic Stress Disorder
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders.
- Conditions
- Major Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder and Agoraphobia
- Trial name
- NCT04293341
- Testing
- Transdiagnostic Behavior Therapy, Cognitive Processing Therapy for PTSD, Cognitive Behavioral Therapy for MDD
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- VA Office of Research and Development
PTSD, Alcohol Use Disorder
Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
The investigators propose to conduct a clinical trial to evaluate sertraline treatment efficacy in a large sample of military veterans with a dual diagnosis of PTSD and Alcohol Use Disorder who are receiving Cognitive and…
- Trial name
- DDx (NCT02504931)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Enhancement of PTSD Treatment With Computerized Executive Function Training
This study focuses on helping Iraq and Afghanistan Veterans with posttraumatic stress disorder (PTSD) benefit fully from therapy by first enhancing their thinking abilities.
- Trial name
- NCT03260127
- Testing
- Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder, Alcohol Abuse
Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Recent needs assessments suggest that difficulties exist in care coordination between emergency medical services (EMS) systems and primary care for injured adolescents with alcohol problems and post-traumatic stress disorder…
- Conditions
- Post-traumatic Stress Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- ATRSCC (NCT00619255)
- Testing
- Adolescent Trauma Support Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder (PTSD)
A Study of Dog Adoption in Veterans With Posttraumatic Stress Disorder (PTSD)
The purpose of this study is to provide preliminary data on the feasibility and impact of adopting a dog from an animal shelter as a supplement to usual care in Veterans with Posttraumatic Stress Disorder (PTSD) who desire to get…
- Trial name
- VITAL (NCT01729026)
- Testing
- Shelter Dog Adoption
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Critical Illness, Psychological Distress
Messy Memories: Mobile Application Therapy Following Critical Illness
The overall goal of this study is to determine whether English-speaking adults who were discharged from an intensive care unit (ICU) at least one month ago and have some level of distress related to their ICU experience will be…
- Conditions
- Critical Illness, Psychological Distress, Health Behavior
- Trial name
- NCT05849454
- Testing
- Messy Memories Intervention
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Stress Disorder, Post Traumatic
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
The purpose of this study is to investigate a new use for a medication called levodopa (L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT02560389
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison
Mild Traumatic Brain Injury, Distress-based Psychopathology
One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology
Traumatic brain injury (TBI) is the signature wound of Veterans returning from the recent operations in Iraq and Afghanistan (i.e OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Mild Traumatic Brain Injury, Distress-based Psychopathology, Chronic Pain
- Trial name
- NCT02844946
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Alcohol Use
CBT Texts for PTSD & Hazardous Drinking (Project Better)
The research study seeks to refine and test a brief, self-directed, intervention for individuals from the general public with PTSD and co-occurring HD that can be delivered via text-messaging.
- Trial name
- NCT05372042
- Testing
- CBT Text Messages
- Where
- United States
- Volunteers
- 505 people
- Sponsor
- University of Washington
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Insomnia, Posttraumatic Stress Disorder
Suvorexant and Trauma Related Insomnia
Problems sleeping are common after exposure to highly threatening experiences and can occur with and without a diagnosis of posttraumatic stress disorder (PTSD).
- Trial name
- NCT02704754
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Howard University
Post Traumatic Stress Disorder
The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Safety and Tolerability of COMP360 in Participants with Post-traumatic Stress Disorder
- Trial name
- NCT05312151
- Testing
- Psilocybin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 22 people
- Sponsor
- COMPASS Pathways
Posttraumatic Stress Disorder
Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
The purpose of this study is to combine a single infusion of Ketamine with 7-days of trauma focus psychotherapy to relieve post traumatic stress disorder (PTSD) symptoms more effectively.
- Trial name
- PTSD (NCT02727998)
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Posttraumatic Stress Disorder
A Case Formulation Approach to Cognitive Processing Therapy
Recent estimates suggest that over 610,000 US Veterans treated by the Veterans Health Administration (VHA) suffer from PTSD, a disorder that can be chronic and debilitating.
- Trial name
- CF-CPT (NCT04407767)
- Testing
- Case Formulation plus Cognitive Processing Therapy, Cognitive Processing Therapy
- Where
- 8 sites in United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Effect of TMS on PTSD Biomarkers
The study will (1) assess feasibility of a TMS treatment in an underserved population; (2) determine if this TMS treatment protocol improves PTSD symptoms and biological markers of PTSD such as brain functioning and startle…
- Trial name
- NCT04563078
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Sleep Initiation and Maintenance Disorders, Post-Traumatic Stress Disorders
Telemedicine Management of Chronic Insomnia
Insomnia is commonly present in Veterans with post-traumatic stress disorder (PTSD). Treatment of insomnia with a specialized type of psychotherapy has been shown to be more effective than treatment with medications.
- Trial name
- VIP (NCT01686438)
- Testing
- Cognitive behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- VA Office of Research and Development
PTSD, Posttraumatic Stress Disorder
The Use of a Novel Peer Education Program for Improving PTSD Treatment Engagement Among Veterans
Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best…
- Trial name
- AboutFace (NCT03521999)
- Testing
- AboutFace, Enhanced Usual Care (eUC)
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- VA Office of Research and Development