Clinical trials: Posttraumatic Stress Symptom, open to volunteers
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms
Veterans with co-morbid posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) are at substantial risk of developing hypertension and cardiovascular diseases that often lead to premature death, with some evidence…
- Trial name
- NCT07756723
- Testing
- Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Coatesville VA Medical Center
Posttraumatic Stress Disorder
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral…
- Trial name
- MAGNETS (NCT06449326)
- Testing
- Active Intermittent theta burst stimulation
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of New Mexico
Posttraumatic Stress Symptoms, Burnout
FLOAT for Healthcare PTSS
This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and…
- Conditions
- Posttraumatic Stress Symptoms, Burnout, Burnout, Healthcare Workers, First Responders
- Trial name
- PTSS FLOAT (NCT07710417)
- Testing
- Floatation-REST, Documentary
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Stress Disorders, Post-Traumatic, Pain, Chronic
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain
Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions…
- Trial name
- NCT07725588
- Testing
- Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Violence, Parenting
Evaluating the Effectiveness of the Common Elements Treatment Approach (CETA) in Peru: Mechanisms of Individual and Intergenerational Change
Recent advances in intervention research have revealed the promise of transdiagnostic, modular approaches implemented by lay paraprofessionals for the treatment of the most prevalent mental health concerns in settings affected by…
- Conditions
- Violence, Parenting, Poverty, Depression
- Trial name
- NCT07667738
- Testing
- Common Elements Treatment Approach, Enhanced Case Managment
- Where
- Peru
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Myocardial Infarction
Anxiety, Stress and Pain & Myocardial Infarction
People often experience the acute phase of a myocardial infarction as a stressful and traumatic event that seems lifethreatening.
- Trial name
- NCT04130269
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
PTSD, Military Activity
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members.
- Conditions
- PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder
- Trial name
- NCT05414708
- Testing
- Art Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Walter Reed National Military Medical Center
Post-traumatic Stress Disorder (PTSD), Trauma and Stress Related Disorders
Grappling With Trauma: Brazilian Jiu-Jitsu for First Responders
This study explores whether participating in an 8-week Brazilian Jiu-Jitsu (BJJ) program is linked to changes in trauma-related symptoms among first responders.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Trauma and Stress Related Disorders, Occupational Stress, Emotional Regulation Difficulties
- Trial name
- CAM-GRIP (NCT07783516)
- Testing
- Brazilian Jiu-Jitsu Program
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Psychosocial Functioning, Stress Disorders, Post-Traumatic
A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms
Posttraumatic stress disorder (PTSD) and depression are the two most common mental health conditions among Veterans. When Veterans experience both, there is a negative impact on their functioning, making it difficult to function…
- Conditions
- Psychosocial Functioning, Stress Disorders, Post-Traumatic, Depressive Disorder, Major
- Trial name
- NCT06689787
- Testing
- Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Diseases, Coronary Artery Disease
Depressive Symptoms After Cardiac Surgery
The primary goal of this project is to develop a predictive model for clinically significant depressive symptoms (CSDS) in patients undergoing coronary artery bypass graft (CABG) surgery, using pre- and perioperative data.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Depression
- Trial name
- PCD (NCT06706323)
- Where
- 2 sites in Switzerland
- Volunteers
- 300 people
- Sponsor
- Roland von Känel
Posttraumatic Stress Disorder (PTSD)
Inflammatory Challenge and Fear
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear.
- Trial name
- LIFE (NCT06630884)
- Testing
- Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Substance Use Disorders, Posttraumatic Stress Symptom
Safe & Sound Protocol in Adults With Trauma and SUD
This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma.
- Conditions
- Substance Use Disorders, Posttraumatic Stress Symptom, Anxiety
- Trial name
- NCT07219056
- Testing
- Safe and Sound Protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Caron Treatment Centers
Posttraumatic Stress Disorder, Depression
Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study
Posttraumatic stress disorder (PTSD) can have significant impairment on aspects of mental well-being (MWB) including functioning, loneliness, physical health, and quality of life.
- Trial name
- NCT07250061
- Testing
- Self-Help Cognitive Processing Therapy, Women Veterans Network (WoVeN), Treatment as Usual
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston University
Posttraumatic Stress Symptoms, Mental Health Conditions
Impact of Dog Adoption and Training in Veterans With Post-traumatic Stress Symptoms and/or Other Mental Health Conditions
The goal of this single-arm study is to learn if a dog adoption and training program can treat, prevent in [describe participant population/primary condition; could include any of the following: sex/gender, age groups, healthy…
- Trial name
- VCRM (NCT07542431)
- Testing
- Dog training
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Florida Atlantic University
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
PTSD, Depression
Positive Processes and Transition to Health - Single-Session (PATH-SS)
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a…
- Trial name
- PATH-SS (NCT06900712)
- Testing
- PATH-SS
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Case Western Reserve University
Breast Cancer
Financial Toxicity, Quality of Life, and Psychological Resources in Breast Cancer Survivors : A Longitudinal Study
Breast cancer survivors face significant financial stress (also called financial toxicity) due to the high costs of cancer treatment. This financial stress can worsen quality of life.
- Trial name
- FTQoL-BC (NCT07651267)
- Volunteers
- 160 people
- Sponsor
- Okayama University
Emotional Regulation, Depression
A Precision Medicine Approach to Target Engagement for Emotion Regulation
The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity.
- Conditions
- Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder
- Trial name
- NCT05651295
- Testing
- Checking the Facts, Opposite to Emotion Action, Mindfulness of Current Emotions
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Matthew Southward, PhD
Posttraumatic Stress Disorder, Myocardial Infarction
EMDR Treatment in PTSD Following Cardiac Events
Cardiac events can often result in debilitating and persistent psychological symptoms. A key question involves whether optimal treatment of cardiac-induced posttraumatic stress disorder (PTSD) reduces PTSD symptoms and thereby…
- Conditions
- Posttraumatic Stress Disorder, Myocardial Infarction, Eye Movement Desensitization and Reprocessing
- Trial name
- EMDR_PTSD_MI (NCT04672551)
- Testing
- EMDR Treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Insomnia
The PSP Sleep Course: An Online Sleep Intervention for Public Safety Personnel With Self-reported Sleep Difficulties.
This study evaluates an internet-delivered cognitive behavioural therapy for insomnia (ICBTi) intervention, known as the PSP Sleep Course, adapted for public safety personnel (PSP) experiencing sleep difficulties.
- Trial name
- NCT07021183
- Testing
- Sleep Course
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Regina