Clinical trials: Postural Hypotension
Orthostatic; Hypotension, Neurogenic
Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
Compare the effect of treatment of midodrine and pyridostigmine in neurogenic orthostatic hypotension and investigate the quality of life of treatment of neurogenic orthostatic hypotension.
- Trial name
- NCT02308124
- Testing
- Midodrine, Pyridostigmine Bromide, Midodrine + pyridostigmine
- Where
- South Korea
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neurogenic Orthostatic Hypotension, Autonomic Failure
CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study
Neurogenic orthostatic hypotension (nOH) is a chronic condition associated with increased cardiovascular risk and reduced quality of life.
- Trial name
- NCT05908760
- Testing
- CO2 ReHaler
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome
Patients with Postural Tachycardia Syndrome (POTS) may not adequately expand their plasma volume in response to a high sodium diet.
- Trial name
- NCT01563107
- Testing
- Plasma Volume, Exercise Capacity Test - Bicycle, Posture Study
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Parkinson Disease, Orthostatic Hypotension
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension…
- Conditions
- Parkinson Disease, Orthostatic Hypotension, Dysautonomia
- Trial name
- NCT05400174
- Testing
- Tilt table (upright position)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Parkinson's Disease, Neurogenic Orthostatic Hypotension in Parkinson's Disease
Abdominal Binder to Treat Orthostatic Hypotension (OH) in Parkinson's Disease (PD)
The purpose of the present study is to determine whether the use of an abdominal binder is effective in the non-pharmacological management of orthostatic hypotension in patients suffering from Parkinson's disease
- Trial name
- ABOHP (NCT01971008)
- Testing
- Elastic abdominal binder
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University Innsbruck
Orthostatic Hypotension, Parkinson's Disease
A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease
This is a study to evaluate the effects of an investigational drug, Droxidopa, in participants with neurogenic orthostatic hypotension (NOH), associated with Parkinson's disease.
- Trial name
- 306A/306B (NCT01176240)
- Testing
- Droxidopa
- Where
- 60 sites in United States
- Volunteers
- 225 people
- Sponsor
- Chelsea Therapeutics
Spinal Cord Injuries, Autonomic Imbalance
Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation.
- Conditions
- Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic; Hypotension, Neurogenic
- Trial name
- NCT04858178
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Cardiovascular Autonomic Function After Resistance Training
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI).
- Trial name
- NCT07725952
- Testing
- Upper-Limb Resistance Training
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Pusan National University Yangsan Hospital
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Orthostatic Hypotension, Spinal Cord Injury
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure.
- Trial name
- NCT00426842
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Symptomatic Neurogenic Orthostatic Hypotension, MSA
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, MSA, Parkinson's Disease (PD), Pure Autonomic Failure (PAF)
- Trial name
- REDWOOD (NCT03829657)
- Testing
- ampreloxetine
- Where
- 82 sites in United States, Australia and 17 more
- Volunteers
- 203 people
- Sponsor
- Theravance Biopharma
Spinal Cord Injury
Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury
This clinical study is designed to investigate the mechanisms of blood pressure regulation and respiratory motor function affected by spinal cord injury (SCI).
- Trial name
- NCT02154412
- Testing
- Respiratory Training
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Hypotension, Orthostatic, Parkinson Disease
Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease
Study on orthostatic Hypotension in Parkinson's disease
- Conditions
- Hypotension, Orthostatic, Parkinson Disease, Autonomic Failure, Cognitive Impairment
- Trial name
- PaKogOH (NCT03900000)
- Testing
- Physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Orthostatic Hypotension
Effective Volemia in Older Adults With Orthostatic Hypotension
Clinical and biological assessments of volemia are challenging in older patients as they are more likely to present non-typical signs.
- Trial name
- EVO (NCT05304806)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Orthostatic Hypotension, Idiopathic Parkinson Disease
Lundbeck TOMs Orthostatic Hypotension
Orthostatic hypotension (OH), which consists in a significant reduction in blood pressure levels upon standing from a seated position, may affect approximately one in three patients with Parkinson's disease (PD).
- Trial name
- NCT04510922
- Testing
- Droxidopa 100 MG [Northera]
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Alberto Espay, MD, MSc
Orthostatic Hypotension
Orthostatic Hypotension in Elderly Nursing Home Residents
In this study the investigators aimed 1. to investigate the prevalence of orthostatic hypotension in elderly nursing home residents. 2.
- Trial name
- NCT01362751
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 290 people
- Sponsor
- Medical Research Foundation, The Netherlands
Hypotension, Orthostatic
A Study for Patients With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright…
- Trial name
- NCT00046475
- Testing
- Midodrine Hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Shire