Clinical trials: Postural Hypotension
Orthostatic Hypotension, Sarcopenia
Sarcopenia and Orthostatic Hypotension
Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries.
- Trial name
- NCT03732716
- Testing
- blood pressure measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Polyneuropathy, Amyloid, Neuropathic Pain
Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)
An International, multicenter, epidemiological observational study investigating the prevalence of Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR-FAP) in participants with small fiber polyneuropathy of no obvious…
- Conditions
- Polyneuropathy, Amyloid, Neuropathic Pain, Cardiac Failure, Orthostatic Hypotension
- Trial name
- TRAP2-1 (NCT01705626)
- Where
- 11 sites in Austria, Hungary and 4 more
- Volunteers
- 500 people
- Sponsor
- CENTOGENE GmbH Rostock
Syncope, Syncope, Vasovagal
Assessment of the Mechanism of Non-cardiac Syncope
Identifying the mechanism of non-cardiac syncope is the essential prerequisite for an effective personalized therapy. Aim of this multicentre, prospective, cross-sectional, observational study is to assess effectiveness and…
- Conditions
- Syncope, Syncope, Vasovagal, Orthostatic Hypotension, Syncope, Carotid Sinus
- Trial name
- 2STEPS (NCT05728255)
- Testing
- ABPM plys SCAFB
- Where
- 8 sites in France, Italy and 3 more
- Volunteers
- 330 people
- Sponsor
- Istituto Auxologico Italiano
Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD)
Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study
The study aims to provide initial proof-of-concept validation data of an artificial intelligence-based model to estimate individual Parkinson's disease risk using demographic, clinical, genetic information and digital biomarker…
- Conditions
- Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD), Neurogenic Orthostatic Hypotension, Hyposmia
- Trial name
- AI-PRA (NCT07706829)
- Testing
- Smartwatch and phone app
- Where
- 3 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Hypotension, Orthostasis
Clinical Trial of Digital Therapeutics (One.Dr) for Suspected Orthostatic Hypotension Patients
Participants who meet the inclusion/exclusion criteria in the Screening visit are randomly assigned 1:1 to the treatment group or the sham control group.
- Trial name
- NCT07348445
- Testing
- Digital therapeutics (One.Dr Application)
- Volunteers
- 86 people
- Sponsor
- Yonsei University
Orthostatic Hypotension
Water and the Gastropressor Response - Tachyphylaxis
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if…
- Trial name
- NCT00580996
- Testing
- water high dose, water tiny dose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Satish R. Raj
Hypotension, Orthostatic
Orthostatic Hypotension in Rehabilitation Patients
The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary…
- Trial name
- NCT00117585
- Testing
- Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- VA Office of Research and Development
Orthostatic Hypotension
Hemodynamic Effects During Land vs Water Exercise for Older Adults With Orthostatic Hypotension
The purpose of the study is to understand how blood pressure, heart rate, and symptoms of low blood pressure (such as dizziness or nausea) are affected by positional changes and exercise when on land or in the water for people…
- Trial name
- NCT05233865
- Testing
- Water exercise, Land exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas at Austin
Parkinson's Disease
The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease
The objective of this experiment is: Primary: To determine the effects of tyrosine supplementation on orthostatic hypotension in people with PD.
- Trial name
- NCT01676103
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York Institute of Technology
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
Hypercapnia in Orthostatic Hypotension
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP).
- Trial name
- NCT05295810
- Testing
- Sequential Gas Delivery
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Autonomic Nervous System Diseases, Orthostatic Hypotension
Treatment of Orthostatic Hypotension
The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00581477
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University
Autonomic Failure, Orthostatic Hypotension
Abdominal Compression in Orthostatic Hypotension
The purpose of this study is to assess if abdominal binders that use pull strings to adjust compression (non-elastic) are more effective than standard elastic abdominal binders in attenuating neurogenic orthostatic hypotension.
- Trial name
- NCT01223391
- Testing
- Abdominal binder, No abdominal binder
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Arterial Stiffness, Renin Angiotensin Aldosterone System
RAAS and Arterial Stiffness in SCI
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
- Conditions
- Arterial Stiffness, Renin Angiotensin Aldosterone System, Orthostatic Hypotension, Spinal Cord Injury
- Trial name
- NCT04510974
- Testing
- Spinal Cord Injury
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Hypotension
An Open Label Trial to Decrease Signs and Symptoms of Orthostatic Hypotension Using Midodrine or Intravenous Fluid Bolus in Patients Following Total Hip Arthroplasty
Orthostatic hypotension following total hip arthroplasty is known to limit the ability of patients to perform physical therapy (PT) and increase the length of hospital stay and costs.
- Trial name
- NCT02154243
- Testing
- Midodrine, Intravenous fluid bolus
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hospital for Special Surgery, New York
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Orthostatic Hypotension
State of Knowledge Among Nurses Regarding the Screening for Orthostatic Hypotension in Elderly Individuals in Acute Geriatric Medicine and Medical and Rehabilitation Services
Orthostatic hypotension is a common geriatric syndrome associated with an increased risk of falls, syncope, functional decline and mortality in older adults.
- Trial name
- HTO-IDE (NCT07738666)
- Testing
- Administration of questionnaires on nurses' knowledge of orthostatic hypotension, its measurement, diagnosis and management
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hôpital NOVO
Spinal Cord Injury, Autonomic Dysfunction
Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury
This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of…
- Conditions
- Spinal Cord Injury, Autonomic Dysfunction, Sexual Dysfunction, Neurogenic Bladder Dysfunction
- Trial name
- NCT05369520
- Testing
- TESCoN or SCONE device - Thoracic stimulation, TESCoN or SCONE device - Lumbosacral stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Hypertension, Pure Autonomic Failure
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension).
- Conditions
- Hypertension, Pure Autonomic Failure, Multiple System Atrophy, Autonomic Failure
- Trial name
- NCT03042988
- Testing
- Heating pad
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Orthostatic Hypotension
Hemodynamic Effects of Aquatic vs. Land Exercise in Patients With Orthostatic Hypotension
Orthostatic hypotension is a highly prevalent deficit in the aging population especially when coupled with stroke, frailty, diabetes, Parkinson's disease or spinal cord injuries.
- Trial name
- NCT04399486
- Testing
- Physical Therapy
- Where
- United States
- Sponsor
- University of Texas at Austin
Orthostatic Hypotension
Vitamin K Status and Markers of Vascular Function in Patients With and Without Postural Hypotension
Postural hypotension is common in older people, leading to falls, decline in function, and dependence. Available treatments have limited efficacy and tolerability; novel approaches to treatment are therefore needed.
- Trial name
- VITKOH (NCT02505282)
- Testing
- Vitamin K status
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee