Clinical trials: Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome
Muscular and Cutaneous Dysfunction in POTS
POTS patients seem to experience orthostasis-dependent muscle weakness and pain as well as increased muscle fatigue upon physical activity, which can be improved by regular aerobic exercise.
- Trial name
- NCT04170725
- Testing
- Patient and Healthy Volunteers training protocol
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Postural Tachycardia Syndrome
Vagal Stimulation in POTS
The purpose of this study is to investigate how the electrical stimulation of a nerve in the skin of the earlobe (transcutaneous vagal nerve stimulation), alone or in combination with two medications (galantamine and…
- Trial name
- NCT03124355
- Testing
- Pyridostigmine Pill, Galantamine Pill, Vagal stimulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
IVIG (Gamunex-C) Treatment Study for POTS Subjects
The purpose of this trial is to evaluate the symptomatic benefits of immunomodulatory treatment with IVIG for POTS (postural tachycardia syndrome) patients with evidence of autoimmunity.
- Trial name
- iSTAND (NCT03919773)
- Testing
- IVIG, Albumin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome
Long COVID Immune Profiling
Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation.
- Conditions
- Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome, Autonomic Dysfunction
- Trial name
- NCT06027255
- Testing
- IL-6, cytokines (IL-17, and IFN-ɣ), Compass 31
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Chronic Fatigue Syndrome
The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS), otherwise known as Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), is an under-recognized disorder whose cause is not yet understood.
- Conditions
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Exercise Intolerance
- Trial name
- NCT03674541
- Testing
- Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brigham and Women's Hospital
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Postural Tachycardia Syndrome
Autonomic Determinants of POTS - Pilot 2
Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. These patients have high heart rate and disabling symptoms during standing. Quality of life may be poor.
- Trial name
- NCT04140721
- Testing
- Moxonidine Pill
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
POTS, POTS - Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19
This study aims to better understand the biological mechanisms underlying dysautonomia and postural orthostatic tachycardia syndrome (POTS), including how these conditions may be related to COVID-19.
- Conditions
- POTS, POTS - Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Autonomic Dysfunction
- Trial name
- fBRI (NCT07405515)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Orthostatic Hypotension, Heart Rate
Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.
Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid…
- Conditions
- Orthostatic Hypotension, Heart Rate, Blood Pressure
- Trial name
- NCT07579026
- Testing
- diaphragmatic breathing exercise, educational retraining
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Standing Cognition and Co-morbidities of POTS Evaluation
The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.
- Trial name
- SCOPE (NCT03602482)
- Testing
- Standing, Supine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
POTS - Postural Orthostatic Tachycardia Syndrome
Restoring Iron Deficiency in POTS
People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body).
- Trial name
- NCT07197905
- Testing
- Intravenous iron
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
Hemodynamic Effects of Compression in POTS
When an individual with Postural Tachycardia Syndrome (POTS) stands up, their heart rate increases significantly (>30BPM) and they may experience symptoms such as lightheadedness, dizziness, shortness of breath, nausea and mental…
- Trial name
- NCT03484273
- Testing
- LifeWrap Compression Garment
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Postural Tachycardia Syndrome
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.
The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and…
- Trial name
- NCT05409651
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome
Transdermal Vagal Stimulation for POTS
Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure. These patient are disabled and can't be in upright position for a longer time.
- Trial name
- NCT02281097
- Testing
- Stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
Compression Garments in the Community With POTS
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting.
- Trial name
- COM-COM-POTS (NCT04881318)
- Testing
- Waist-High Compression Tights, Abdominal Compression Garments, Medications that modulate heart rate and blood pressure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome, COVID-19
Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, COVID-19, Post COVID-19 Condition, Post-Acute COVID-19 Syndrome
- Trial name
- NCT05877534
- Testing
- Individual tailored exercise
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
POTS - Postural Orthostatic Tachycardia Syndrome
RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome
RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing.
- Trial name
- RESET-POTS (NCT07837804)
- Testing
- Bilateral Sequential Stellate Ganglion Block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana