Clinical trials: Postural Tachycardia Syndrome
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome
Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS
The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic…
- Trial name
- POTS (NCT05633407)
- Testing
- Efgartigimod
- Where
- 11 sites in United States
- Volunteers
- 53 people
- Sponsor
- argenx
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ehlers Danlos Syndrome, External Hydrocephalus
Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life
It is known that 33-50% of Classic and Hypermobile Ehlers-Danlos Syndrome patients eventually develop dysautonomia, otherwise known as "POTS" (Postural Orthostatic Tachycardia Syndrome).
- Conditions
- Ehlers Danlos Syndrome, External Hydrocephalus, Dysautonomia, Postural Orthostatic Tachycardia Syndrome
- Trial name
- NCT01367977
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Genetic Disease Investigators
Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS)
Presentation of Young Adults With and Without Joint Hypermobility
People with multiple hypermobile joints are diagnosed with Generalized Joint Hypermobility (GJH) when asymptomatic, or Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) when symptomatic…
- Trial name
- NCT07657507
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Postural Orthostatic Tachycardia Syndrome
Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)
This study is designed to investigate whether the treatment of non-anemic iron deficiency with intervenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in adolescents (age 12-21)…
- Trial name
- NCT01978535
- Testing
- Iron infusion, Normal saline infusion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome
Compression Garments in the Community With POTS
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting.
- Trial name
- COM-COM-POTS (NCT04881318)
- Testing
- Waist-High Compression Tights, Abdominal Compression Garments, Medications that modulate heart rate and blood pressure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Postural Tachycardia Syndrome
Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
This study is to determine different chemical levels in the blood during a low salt diet. This study will compare normal volunteers to those with Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT01764711
- Testing
- Cosyntropin administration
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Vasovagal Syncope, Postural Tachycardia Syndrome
Hypnosis in Autonomic Function
This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating).
- Conditions
- Vasovagal Syncope, Postural Tachycardia Syndrome, Hypnosis
- Trial name
- NCT00061009
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post-COVID-19 Syndrome, Long COVID
ImPROving Quality of LIFe in the Long COVID Patient
The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with placebo/ritonavir to improve quality of life in non-hospitalized adult participants suffering from post-acute…
- Conditions
- Post-COVID-19 Syndrome, Long COVID, Long Covid19, COVID-19
- Trial name
- PROLIFIC (NCT05823896)
- Testing
- Nirmatrelvir/ritonavir
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Karolinska Institutet
Postural Orthostatic Tachycardia Syndrome
Cardiovascular Effects of Selective I(f)-Channel Blockade
The study compares three treatment modalities in a human model of Postural orthostatic tachycardia syndrome (POTS): beta-blockers, I(f)-blockers, and placebo.
- Trial name
- NCT00865917
- Testing
- beta-blocker (Metoprolol), I(f)-blocker (ivabradine)
- Where
- 2 sites in Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Vomiting Syndrome, Irritable Bowel Syndrome
Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea
Retrospectively review the charts of all children who had heart rate variability, deep breathing test, valsalva maneuver, tilt table test, thermoregulatory sweat testing, quantitative sudomotor axon reflex test (QSART) completed…
- Conditions
- Vomiting Syndrome, Irritable Bowel Syndrome, Postural Orthostatic Tachycardia Syndrome, Abdominal Pain
- Trial name
- NCT00728026
- Volunteers
- 19 people
- Sponsor
- Medical College of Wisconsin
Postural Orthostatic Tachycardia Syndrome (POTS)
Beta-3 Enhanced Autonomic Therapy for POTS
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
- Trial name
- BEAT-POTS (NCT07585513)
- Testing
- Mirabegron
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Postural Orthostatic Tachycardia Syndrome (POTS)
aVNT in POTS - Pilot
Autonomic nervous system imbalance causes postural tachycardia and related cardiac symptoms in Postural Orthostatic Tachycardia Syndrome (POTS). The impact of POTS is more far-reaching than postural tachycardia.
- Trial name
- NCT07026643
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Chronic Fatigue Syndrome, Orthostatic Intolerance
Autonomic Nervous System and Chronic Fatigue Syndrome
The investigators propose to test the hypothesis that the sympathetic nervous system contributes to the cardiovascular and inflammatory abnormalities present in the chronic fatigue syndrome (CFS) and, in particular in the subset…
- Conditions
- Chronic Fatigue Syndrome, Orthostatic Intolerance, Postural Tachycardia Syndrome
- Trial name
- CFS&ANS (NCT00580619)
- Testing
- Autonomic Function Testing, Saline infusions, L-NMMA trimethaphan
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome
In this pilot study, the investigators will test the hypothesis that patients with postural tachycardia syndrome will have an elevated percentage of functional antibodies to adrenergic receptors compared with control subjects…
- Trial name
- NCT02196376
- Testing
- History, Physical, blood draw
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postural Orthostatic Tachycardia Syndrome (POTS)
Programming Aquatic Therapy for POTS
The goal of this pilot study is to create, implement, and evaluate an aquatic therapy for Postural Orthostatic Tachycardia Syndrome (POTS) program feasibility and ability to improve quality of life as determined by reduced…
- Trial name
- NCT07182578
- Testing
- Aquatic Occupational Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- California State University, Dominguez Hills