Clinical trials: Pouch, Ileal
Familial Adenomatous Polyposis (FAP), Pouches, Ileoanal
Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL)
This international, multi-centre randomised controlled trial will compare dye-based chromoendoscopy with virtual chromoendoscopy, using NBI/BLI, for adenoma detection during routine surveillance pouchoscopy in adults with…
- Trial name
- ENDOPOL (NCT07726771)
- Testing
- Chromoendoscopy (Indigo Carmine), Virtual Chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- London North West Healthcare NHS Trust
Obesity, Ulcerative Colitis
A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis
The purpose of this research is to gather information on the safety and effectiveness of Endoscopic Sleeve Gastroplasty (ESG) for weight loss in a population of obese UC patients undergoing colectomy with eventual IPAA.
- Trial name
- NCT05739162
- Testing
- Apollo Endoscopic Suture System, Lifestyle Intervention
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Pouchitis, Pouches, Ileoanal
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Participants will: Take…
- Conditions
- Pouchitis, Pouches, Ileoanal, Pouch, Ileal
- Trial name
- NCT06864403
- Testing
- Mirikizumab - Intravenous (IV), Mirikizumab - Subcutaneous (SC)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Pouchitis, Crohn's Disease
Stem Cells for the Treatment of Pouchitis
The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with medically refractory Pouchitis.
- Conditions
- Pouchitis, Crohn's Disease, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases
- Trial name
- NCT05578508
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Sponsor
- The Cleveland Clinic
Ulcerative Colitis (UC), Pouchitis
ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients After Pelvic Pouch Surgery
Ulcerative colitis (UC) is a chronic intestinal disease, often debuting early in life, and affecting the colon and rectum. The therapy is mainly medical and based on 5-aminosalicylic acid (5-ASA) and steroids.
- Trial name
- ASAPP (NCT07773948)
- Testing
- 5-ASA
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- University Hospital, Linkoeping
Ulcerative Colitis, Colorectal Cancer
Subjective Near-infrared Fluorescence Guidance in Perfusion Assessment of Ileal Pouch Formation and Ileal-pouch-anal Anastomosis
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at three time points during ileal pouch…
- Conditions
- Ulcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous Polyposis
- Trial name
- NCT04695184
- Testing
- ICG-NIRF Imaging
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Ulcerative Colitis
Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU)
The purpose of this study is to investigate a new technique: Close Rectal Dissection (CRD) as restorative surgery for Ulcerative Colitis patients: the Close Rectal Ileo Pouch Anal Anastomosis (CR-IPAA).
- Trial name
- CR-IPAA (NCT01111708)
- Testing
- Close Rectal Dissection - IPAA
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Medical Center Nijmegen
Ulcerative Colitis, Pouchitis
Adalimumab in the Treatment of Chronic Pouchitis
This study wants to investigate the efficiency of biological treatment for chronic pouchitis. Chronic pouchitis is inflammation in a reconstruction after removal of the colon, a pouch.
- Trial name
- ADAP (NCT01670240)
- Testing
- Adalimumab
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Odense University Hospital
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Ulcerative Colitis
Outcomes of Transanal Tran-section and Single-stapled (TTSS) Ileal Pouch-Anal Anastomosis
This study aims to compare the functional and surgical outcomes of Ulcerative Colitis (UC) patients undergoing Transanal Transection and Singl-Stapled (TTSS) versus Double-stapled Ileal Pouch-Anal Anastomosis (IPAA)
- Trial name
- TTSS-Pouch (NCT06331637)
- Testing
- Transanal Transection and Single-Stapled anastomosis (TTSS), Double-stapled anastomosis
- Where
- Italy
- Volunteers
- 174 people
- Sponsor
- Istituto Clinico Humanitas
Ulcerative Colitis, Ileal Pouch
MRI Anastomotic Integrity of Pelvic Intestinal Anastomoses
This protocol describes using an MRI-Enema technique to assess the integrity of colorectal anastomoses when compared to fluoroscopic water soluble contrast enema, and provides information the participant recruitment process…
- Conditions
- Ulcerative Colitis, Ileal Pouch, Anastomotic Leak
- Trial name
- NCT04719169
- Testing
- Dynamic MRI enema, Fluoroscopic enema
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- London North West Healthcare NHS Trust
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Pouchitis
Exploring the Influence of Trptophan on the Treatment of Pouchitis
Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation…
- Trial name
- TryProPouch (NCT06861140)
- Testing
- Tryptophan 25mg/kg bodyweight
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf