Clinical trials: Pouchitis, open to volunteers
Chronic Pouchitis, Pouchitis
Fecal Microbiota Transplant for Patients With Chronic Pouchitis
The purpose of this research study is to assess the safety and efficacy of fecal microbiota transplant (FMT) in the treatment of chronic pouchitis.
- Trial name
- NCT05829109
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Maia Kayal
Ulcerative Colitis (UC), Pouchitis
ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients After Pelvic Pouch Surgery
Ulcerative colitis (UC) is a chronic intestinal disease, often debuting early in life, and affecting the colon and rectum. The therapy is mainly medical and based on 5-aminosalicylic acid (5-ASA) and steroids.
- Trial name
- ASAPP (NCT07773948)
- Testing
- 5-ASA
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- University Hospital, Linkoeping
Pouchitis
Exploring the Influence of Trptophan on the Treatment of Pouchitis
Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation…
- Trial name
- TryProPouch (NCT06861140)
- Testing
- Tryptophan 25mg/kg bodyweight
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pouchitis, UC - Ulcerative Colitis
Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC)
The goal of this single-arm, prospective clinical trial is to assess the clinical efficacy and safety of oral Aeromonas sp. MTB-specific phage therapy in adult participants aged 18-70 years with pouchitis following ileal…
- Trial name
- NCT07878026
- Testing
- MTB-targeted phage therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jinling Hospital, China
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Pouchitis, Pouches, Ileoanal
Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch
The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Participants will: Take…
- Conditions
- Pouchitis, Pouches, Ileoanal, Pouch, Ileal
- Trial name
- NCT06864403
- Testing
- Mirikizumab - Intravenous (IV), Mirikizumab - Subcutaneous (SC)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Pouchitis
Etrasimod as Prevention of Pouchitis
The researchers propose conducting a multi-center, randomized, placebo-controlled study to investigate the potential role of etrasimod for the primary and secondary prevention of pouchitis among high-risk patients submitted to…
- Trial name
- ESPIRIT (NCT07486921)
- Testing
- etrasimod
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Maia Kayal
Ileal Pouch
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
The aim of this study is to assess the safety and preliminary efficacy of treatment with EXE-346, a live biotherapeutic, which may reduce bowel movement frequency in patients with an ileal pouch-anal anastomosis (IPAA) and lead…
- Trial name
- PROF (NCT05938465)
- Testing
- EXE-346
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Exegi Pharma, LLC
Pouchitis
GUselkumAb inteRvention and DIet evaluAtioN for Pouchitis
Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is considered the procedure of choice in patients with ulcerative colitis (UC) refractory to medical therapy or with neoplasia.
- Trial name
- GUARDIAN (NCT06916390)
- Testing
- Guselkumab, Diet
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pouchitis
A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
When some people have their large bowel removed, a surgeon can make a "pouch" from part of the small bowel to connect it to the back passage (anus). Pouchitis is when the pouch becomes inflamed (swollen) or infected.
- Trial name
- NCT06443502
- Testing
- Vedolizumab, Concomitant Antibiotic Therapy
- Where
- 14 sites in Belgium, Croatia and 6 more
- Volunteers
- 30 people
- Sponsor
- Takeda
Pouchitis
Rifaximin for the Secondary Prevention of Recurrent Pouchitis
Although many people will develop recurrent pouchitis (inflammation of the ileal pouch-anal anastomosis or J-pouch after colectomy for ulcerative colitis) after an initial episode of pouchitis, there are currently no effective…
- Trial name
- NCT06312683
- Testing
- Rifaximin 550 MG Oral Tablet [XIFAXAN]
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill