Clinical trials: Pragmatic Randomized Controlled Trial
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Sedentary Behavior, Physical Activity
Teen Mom Study: A Confirmatory Pragmatic Cluster RCT
The goal of this clinical trial is to test the effectiveness of #BabyLetsMove - a 24-week mobile Health and peer health coaching intervention paired with the Special Supplemental Nutrition Program for Women, Infants, and Children…
- Conditions
- Sedentary Behavior, Physical Activity, Gestational Weight Gain, Arterial Pressure
- Trial name
- NCT06216925
- Testing
- #BabyLetsMove, WIC Antenatal Care
- Volunteers
- 144 people
- Sponsor
- University of Mississippi Medical Center
Ovarian Cancer, Endometrium Cancer
ROGYcare: The Impact of a Cancer Survivorship Care Plan on Patient Reported Outcomes and Health Care Providers
Earlier diagnoses and improved treatments have contributed to the growing cohort of cancer survivors. Nevertheless, these patients remain at risk for adverse long-term or late physical or psychosocial effects of cancer and its…
- Trial name
- ROGYcare (NCT01185626)
- Testing
- SCP care
- Where
- 12 sites in Netherlands
- Volunteers
- 396 people
- Sponsor
- Lonneke van de Poll-Franse
Chronic Kidney Disease Stage 5, End Stage Renal Disease
CKD Specific Telemonitoring Platform to Minimize Adverse Outcomes in High Risk CKD Patients
The main purpose of this trial is to determine whether the addition of the VIEWER virtual care platform to usual care will lead to a reduction in composite emergency department (ED) visits and/or hospitalizations/or increase the…
- Trial name
- VIEWER (NCT05726526)
- Testing
- VIEWER virtual care platform
- Where
- 5 sites in Canada
- Volunteers
- 340 people
- Sponsor
- University of Manitoba
Multimorbidity
Self-Management Program for Older Adults With Multimorbidity
Patients with multimorbidity move between multiple care settings, and so they are at high risk of receiving fragmented care leading to increased risk for avoidable illness, death, and health care costs.
- Trial name
- NCT02209285
- Testing
- Self-Management Program for Older Adults with Multimorbidity
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- McMaster University
Cancer
Enhancing the Patient Journey to Clinical Trial Enrolment With Navigation to Optimize Accrual
Less than 5% of patient enter clinical trials, despite the fact that many patients facing cancer are recommended to seek out clinical trials.
- Trial name
- NCT06905002
- Testing
- Educational program
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Windsor Regional Hospital
Preventive Effectiveness, Elderly With Qi-deficiency Constitution
The Preventive Effectiveness of the Individualized Jade Wind-Barrier Herbal Tea Bag on the Common Cold in Elderly With Qi-deficiency Constitution (CCJWBT): A Pragmatic Randomized Controlled Trial
Objectives Based on the individualized Jade Wind-Barrier Herbal Tea Bag intake after randomization, to evaluate the relationship of the individualized Jade Wind-Barrier Herbal Tea Bag intake and the improvement of Qi-deficiency…
- Conditions
- Preventive Effectiveness, Elderly With Qi-deficiency Constitution, The Individualized Jade Wind-Barrier Herbal Tea Bag, Common Cold
- Trial name
- CCJWBT (NCT05640570)
- Testing
- The individualized Jade Wind-Barrier Herbal Tea Bag
- Where
- China
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Heart Failure
The SELEQT-HF (SELEnium and CoQ10 NuTrition for Heart Failure) Study Will Evaluate the Effect of Adding Selenium/and coQ10 on Top of Standard HF Therapy in Patients With HF and Will do so Using a Pragmatic, Registry Based Randomized Controlled Trial in the Netherlands.
The goal of this clinical trial is to learn whether taking selenium and coenzyme Q10 (CoQ10) can reduce HF related events and deaths related to cardiovascular disease.
- Trial name
- SELEQT-HF (NCT07234422)
- Testing
- Selenium/CoQ10
- Where
- 7 sites in Netherlands
- Volunteers
- 1,100 people
- Sponsor
- Netherlands Heart Institute
Stroke
Rehabkompassen® - a Patient-centered Digital Follow-up Tool in the Post-stroke Continuum of Care
Stroke is a leading cause of disability and with a heavy burden for the society. Despite the demands from 'Socialstyrelsen' of improving post-acute care, an effective structured follow-up to promote a patient-tailored…
- Trial name
- NCT04915027
- Testing
- a usual follow-up with Rehabkompassen®, a usual follow-up with Post-Stroke Checklist, i.e. without Rehabkompassen®
- Where
- Sweden
- Volunteers
- 1,106 people
- Sponsor
- Umeå University
Post-traffic Accident Fatigue
The Efficacy and Safety of Herbal Medicine Treatment Strategy for Patients With Post-Accident Fatigue
This study is a pragmatic randomized controlled pilot clinical trial aimed at evaluating the efficacy and safety of herbal medicine treatment strategy for patients with post-traffic accident fatigue, using an education-only group…
- Trial name
- TA fatigue (NCT07254169)
- Testing
- Herbal medicine, Education
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Colles' Fracture, Distal Radius Fracture
Conservative Treatment of Distal Radius Fracture in Elderly in Randomized Controlled Trial
There is no consensus about the best conservative treatment for patients with dorsally displaced distal radius fractures. The previous studies that have examined the most valid method for cast immobilization have lacked uniform…
- Trial name
- NCT02894983
- Testing
- Flexion-ulnar cast, Functional cast
- Where
- 3 sites in Finland
- Volunteers
- 114 people
- Sponsor
- Tampere University Hospital
Mental Health Wellness 1, COVID
Telepsychoeducation for the Prevention of Emotional Distress in Professionals and Students From Essential Services in the Context of COVID-19
A pragmatic superiority randomized controlled trial comparing Telepsychoeducation plus personalized videos vs. Telepsychoeducation without personalized videos for the prevention of future emotional distress in professionals and…
- Conditions
- Mental Health Wellness 1, COVID, Emotional Distress, Depressive Symptoms
- Trial name
- NCT04632082
- Testing
- Telepsychoeducation with personalized videos, Telepsychoeducation without personalized videos
- Where
- Brazil
- Volunteers
- 2,200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Kidney Disease, Chronic, Peritoneal Dialysis Catheter-Associated Peritonitis
Targeted Education ApproaCH to Improve Peritoneal Dialysis Outcomes Trial
For many patients peritoneal dialysis (PD) is the preferred form of dialysis to treat kidney disease as it provides greater flexibility and the ability to dialyse at home.
- Conditions
- Kidney Disease, Chronic, Peritoneal Dialysis Catheter-Associated Peritonitis, Peritoneal Dialysis Catheter Exit Site Infection, Peritoneal Dialysis Catheter Tunnel Infection
- Trial name
- TEACH-PD (NCT03816111)
- Testing
- TEACH-PD Training Curriculum, Current standard PD training
- Where
- 48 sites in Australia, New Zealand
- Volunteers
- 1,462 people
- Sponsor
- The University of Queensland
Anti-Synthetase Syndrome, Interstitial Lung Disease (ILD)
A Randomized, Double-Blind, Placebo-Controlled Trial of Fufei Huazhuo Tongluo Formula Combined With Standardized Medicine in Patients With Anti-Synthetase Syndrome-Associated Interstitial Lung Disease
The goal of this clinical trial is to learn if the traditional Chinese medicine formula "FuFei HuaZhuo TongLuo Granule" combined with standardized western medicine works to treat anti-synthetase syndrome-associated interstitial…
- Trial name
- NCT07836790
- Testing
- FuFei HuaZhuo TongLuo Granule
- Where
- China
- Volunteers
- 54 people
- Sponsor
- First People's Hospital of Hangzhou
Sarcopenia in Elderly
RANKL Inhibition to Combat Sarcopenia in Hip Fracture Patients
The objective of this study is to conduct a pragmatic, randomized, double-blind, active-controlled trial to assess the efficacy of receptor activator of nuclear factor-kB ligand (RANKL) inhibition in the treatment of sarcopenia…
- Trial name
- NCT07056478
- Testing
- Denosumab (Prolia), Zoledronic acide (Aclasta)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Morning Rounds, Teaching Rounds
A Pragmatic Cluster Randomized Controlled Trial to Standardize Attending Morning Rounds in Medicine
Attending morning rounds take place at teaching hospitals every day. They are the primary mechanism for patient care delivery, supervision and education of trainees, and communication with patients, families, and staff.
- Conditions
- Morning Rounds, Teaching Rounds, Hospitalization, Inpatients
- Trial name
- NCT01931553
- Testing
- Standardized attending morning rounds
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of California, San Francisco
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Immunization Coverage, Vaccination
Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months
Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization…
- Conditions
- Immunization Coverage, Vaccination, Nutrition
- Trial name
- NCT06387511
- Testing
- Small-quantity lipid-based nutrition supplements (SQ-LNS) NutriVax, Sensitization on vaccination and on Infant and Young Child Feeding (IYCF) practices
- Where
- Nigeria
- Volunteers
- 3,814 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Chronic Low-back Pain
Effectiveness and Safety of Pharmacopunture Therapy for Chronic Low Back Pain: A Pragmatic Randomized Controlled Trial
This is a multi-center, 2-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy with physical therapy for chronic low back pain.
- Trial name
- NCT04833309
- Testing
- pharmacopuncture therapy, physical therapy
- Where
- 4 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Jaseng Medical Foundation