Clinical trials: Pre Eclampsia
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Postpartum Hemorrhage, Postpartum Depression
Postpartum Video Education in High Risk Populations
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Depression, Postpartum Sepsis, Postpartum Preeclampsia
- Trial name
- NCT06310720
- Testing
- Video Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Preeclampsia
Aspirin for Prevention of Preeclampsia in Healthy, Nulliparous Obese and Overweight Pregnant Women
Preeclampsia is a pregnancy-specific syndrome that affects 3 - 5% of pregnancies. It is one of the main causes of maternal, fetal and neonatal morbidity and mortality, resulting in approximately 40,000 maternal deaths worldwide…
- Trial name
- NCT03725891
- Testing
- Aspirin 162 mg, Aspirin 81 mg
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Aswan University Hospital
Pre-eclampsia or Eclampsia With Pre-existing Hypertension
Evaluation of a Physical Therapy Protocol on Quality of Life Musculoskeletal Pain and Anxiety in Women With Preeclampsia
The purpose of this study is to verify that the implementation of a protocol physiotherapy musculoskeletal pain and reduces anxiety and improves quality of life in patients hospitalized at the clinic of high-risk pregnancies at…
- Trial name
- NCT01925508
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases, Heart Diseases
Oral Calcium in Pregnant Women With Hypertension
To determine of providing calcium supplementation to women with pre-existing hypertension reduces the level of blood pressure, requirement for antihypertensive drugs, and incidence of pre-eclampsia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pre-Eclampsia
- Trial name
- NCT00000543
- Testing
- dietary supplements, calcium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hypertension in Pregnancy, Postpartum Preeclampsia
Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension
The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water…
- Trial name
- ACE (NCT05049616)
- Testing
- ACE Inhibitors and Diuretics, NIFEdipine ER
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The University of Texas Health Science Center, Houston
Urinary Tract Infection (Diagnosis), Preeclampsia
Association of Urinary Tract Infection With Preeclampsia During Pregnancy
Urinary tract infections (UTIs) are a major clinical issue, especially in pregnant women, due to physiological changes that increase susceptibility.
- Trial name
- NCT06962644
- Testing
- Preeclampsia developed
- Where
- Pakistan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Preeclampsia With Severe Features
Use of Cheetah® Cardiac Monitoring System to Guide Discontinuation of Magnesium Sulfate in Women With Severe Preeclampsia
This is a single site pilot randomized, controlled, trial randomizing patients with PE with severe features to one of 2 groups: 24 hours of postpartum magnesium sulfate (current arbitrary standard of care) Using the Cheetah®…
- Trial name
- NCT04474704
- Testing
- Cheetah® non-invasive cardiac monitoring system, Standard of care
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Preeclampsia
Effect of Stretching Exercises Versus Aerobic Exercises on Preeclampsia
The purpose of the study is to compare between the effect of stretching exercises and aerobic exercises on preeclampsia.
- Trial name
- NCT07255677
- Testing
- Stretching exercises program, Aerobic exercises program, Antihypertensive drugs
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Preeclampsia With Severe Features
Acute Labetalol Use in Preeclampsia
The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's body-mass index, will be more effective at controlling severe hypertension…
- Trial name
- ALERT (NCT03872336)
- Testing
- Experimental labetalol dose, Current standard of care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Albany Medical College
Preeclampsia
Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders
Preeclampsia (PE) is a significant cause of maternal and fetal morbidity and mortality, characterized by high blood pressure and proteinuria during pregnancy.
- Trial name
- MATER (NCT06421493)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Infertility, Eclampsia Preeclampsia
Modelization of Early Endometrial-trophoblast Molecular Interaction
Despite significant advances in assisted reproductive technology, only 25% of in vitro fertilization (IVF) embryo transfers result in pregnancy, largely due to implantation failure.
- Trial name
- MEETMI (NCT07825649)
- Testing
- Diagnostic hysteroscopy with endometrial biopsy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Microalbuminuria, Preeclampsia
Lisinopril for Renal Protection in Postpartum Preeclamptic Women
There may be a role for Lisinopril in improving renal protection in post-partum women who had preeclampsia during pregnancy. The aim of this study is to determine whether routine initiation of Lisinopril after delivery, in women…
- Trial name
- NCT05016440
- Testing
- Lisinopril
- Where
- United States
- Sponsor
- Eastern Virginia Medical School
Preeclampsia
The Expression of Aquaporin 3, 8 and 9 in Placenta in Normal and Preeclamptic Pregnancies: Perinatal and Neonatal Outcomes.
The etiologic agent responsible for the development of preeclampsia remains unknown. Aquaporins, members of integral membrane proteins, are responsible of water molecules movements through the plasma membrane channels, energy…
- Trial name
- NCT02045316
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Rakhshanda Aslanova
PREG1
Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain
The aim of this observational study is to compare postoperative analgesic consumption in patients who received peroperative carbetocin or oxytocin. The main question it aims to answer is: .
- Trial name
- NCT06692621
- Testing
- Oxytocin, Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Anemia in Pregnancy, Preeclampsia
A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy
This study is a multi-site, retrospective chart review to determine the effect of Neevo® or Neevo®DHA (with higher folate and B12) versus standard prenatal vitamins on hemoglobin (Hgb) levels in pregnant women throughout the…
- Trial name
- NCT01062958
- Testing
- Neevo® (a medical food), Prenatal vitamins (≤1mg folic acid, 27 - 35mg iron, and ≤12mcg vitamin B12)
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Pre Eclampsia
Study of Coagulation Activation Markers and Pre Eclampsia
The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
- Trial name
- PRESTIGE (NCT01261351)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Phthalate Exposure, Preeclampsia
The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia
Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes.
- Conditions
- Phthalate Exposure, Preeclampsia, Estrogen, Progestin
- Trial name
- NCT04777929
- Testing
- test Phthalates, estrogen and progesterone
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University