Clinical trials: Pre Eclampsia
High Risk Pregnancy
Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies
Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical underlying placental pathology revealing small placentas and maldevelopment of the decidual blood vessels, suggesting under-perfusion…
- Trial name
- NCT01355822
- Testing
- PETN
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- University of Jena
Pulmonary Edema - Acute, Preeclampsia
Lung Ultrasound for the Detection of Volume Overload in Patients With Severe Preeclampsia
This research aims to evaluate the usefulness of lung ultrasound (LUS) for detecting and monitoring fluid overload in patients with severe preeclampsia.
- Trial name
- NCT07261956
- Testing
- Lung ultrasound
- Where
- Panama
- Volunteers
- 202 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia
Introduction: The etiology/pathophysiology of preeclampsia remains an enigma. Cellular immunity is a key factor in the etiology of late-onset preeclampsia (L-PrE).
- Trial name
- Presepsin&PE (NCT04126902)
- Testing
- interleukin-6, presepsin and pentraxin-3
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Hypertension, Cardiovascular Diseases
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
The purpose of this study is to understand more about why women who have had hypertensive pregnancies may be at increased risk of high blood pressure and why these women are often at increased risk of heart and blood vessel…
- Conditions
- Hypertension, Cardiovascular Diseases, Cerebrovascular Disorders, Vascular Diseases
- Trial name
- HELPFUL (NCT06187012)
- Testing
- Hypertensive pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Pre-Eclampsia, Pregnancy
Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia
Preeclampsia is associated with significant maternal and fetal morbidity and mortality. Early identification and subsequent management of patients at risk of developing preeclampsia presents an ongoing challenge in prenatal care.
- Conditions
- Pre-Eclampsia, Pregnancy, Hypertension
- Trial name
- NCT01351428
- Testing
- Nifedipine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pre-eclampsia, Pre-Term
Study of Pregnancy Pathologies Associated With Placental Abnormalities
Pregnancy pathologies can occur from implantation until childbirth. The investigators are interested in the development mechanisms of these pathologies and aim to develop therapies to treat them.
- Conditions
- Pre-eclampsia, Pre-Term, Fetal Growth Retardation
- Trial name
- NCT05188066
- Testing
- Histology
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Pre-Eclampsia
Utilization of Somatic Tissue Oxygen Saturation Monitoring in Pregnant Women
The purpose of this study is to compare 3 methods of assessing endothelial function in healthy female volunteers and pregnant women with and without pregnancy induced hypertension.
- Trial name
- NCT03196141
- Testing
- StO2 and EndoPAT
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Heart Failure, Diastolic Dysfunction
Timely Recovery After Subclinical Heart Failure
The goal of this randomized controlled trial is to assess the effectiveness of ACE inhibitors versus standard care) in reversing asymptomatic heart failure (HF stage-B) and/or diastolic dysfunction during a two-year open-label…
- Trial name
- TREASURE (NCT06341101)
- Testing
- Perindopril
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Preeclampsia, Pregnancy Toxemias
Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean
Anesthesia for cesarean section has been a great challenge for the anesthesiologist, for mother and fetus are closely related. So the challenge is to anesthetize the mother without interfering with the physiology of the fetus.
- Trial name
- Vasopressors (NCT01451060)
- Testing
- Metaraminol, Ephedrine
- Where
- Brazil
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Pre-Eclampsia
Predictors of Intrauterine Growth Restriction
The main objectives of modern antenatal care programs are to identify high risk pregnancies then to predict any possibility of adverse pregnancy outcome as early as possible.
- Trial name
- NCT03349671
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Assiut University
Pre-Eclampsia, Gestational Diabetes
Development of Intervention for Women After Gestational Diabetes or Pre-eclampsia
Our objectives in this qualitative exploratory study: To explore the perspectives and preferences of women with preeclampsia and/or GDM history related to a potential health promotion program To identify perception of support…
- Trial name
- NCT04716244
- Testing
- interview/focus group/questionnaire
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Pre-eclampsia
Dietary Intervention Program for Pre-eclampsia in Women at Risk
Aims: Pre-eclampsia is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. Preeclampsia frequency is 2-8% from all pregnancies.
- Trial name
- NCT02706158
- Testing
- 1500 mg Calcium and 1200 IU Vitamin D for 2 months, balanced diet
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Pregnancy Complications, Ultrasound Therapy; Complications
Lung Ultrasound Patterns Preeclampsia
Evaluation of lung ultrasound as a diagnostic tool in pregnant patients.
- Conditions
- Pregnancy Complications, Ultrasound Therapy; Complications, Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT03576092
- Testing
- Lung Ultrasound
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Heart Diseases
Renin and Prorenin in Pregnancy
To determine the role of the prorenin-renin-angiotensin-aldosterone system (RAAS) in normal and hypertensive pregnancy.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005207
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Urinary Tract Infection (Diagnosis), Preeclampsia
Association of Urinary Tract Infection With Preeclampsia During Pregnancy
Urinary tract infections (UTIs) are a major clinical issue, especially in pregnant women, due to physiological changes that increase susceptibility.
- Trial name
- NCT06962644
- Testing
- Preeclampsia developed
- Where
- Pakistan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Preeclampsia, Microbiome
A Multicenter Cohort Study on Maternal and Infant Microecology and New Targets for Pre-eclampsia Screening in China
major objective This multicenter, prospective cohort study aims at evaluating the predictive value of microbiome ,proteomics and serum markers in preeclampsia.
- Trial name
- CALM2001 (NCT05445544)
- Testing
- Observational studies, The diagnosis was preeclampsia
- Where
- 2 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Preeclampsia
Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Case-control Study
A case-control study will evaluate the clinical utility of the Congo Red test GV-005 in following women with a clinical diagnosis of preeclampsia and clinically healthy women in the postpartum period
- Trial name
- NCT02610972
- Testing
- Congo Red test GV-005
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the efficacy and safety of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556357
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 138 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypertensive Disorders of Pregnancy, Preeclampsia
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy…
- Conditions
- Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- ASPIRIN (NCT06468202)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- 20 sites in United States
- Volunteers
- 10,742 people
- Sponsor
- Ohio State University