Clinical trials: Pre Eclampsia
Pre-Eclampsia; Complicating Pregnancy, Blood Loss
Blood Loss and Preeclampsia
Study of blood loss in preeclamptic patients using mathematical formulae
- Conditions
- Pre-Eclampsia; Complicating Pregnancy, Blood Loss, Coagulation Disorder
- Trial name
- NCT04777097
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Pre-Eclampsia
Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial (FORECAST)
This implementation study aims to evaluate the efficacy, acceptability, and safety of first-trimester screening and prevention for preterm-preeclampsia.
- Trial name
- FORECAST (NCT03941886)
- Testing
- Low-dose aspirin in women with high risk of preeclampsia
- Where
- 19 sites in China, Hong Kong and 8 more
- Volunteers
- 42,454 people
- Sponsor
- Chiu Yee Liona Poon
Preeclampsia, Severe Preeclampsia
Complement Regulation to Undo Systemic Harm in Preeclampsia
This is a Phase II, single arm, open-label study to determine if treatment with eculizumab prolongs pregnancy compared to historical controls in women with preeclampsia between 23-30 weeks gestation.
- Conditions
- Preeclampsia, Severe Preeclampsia, Eculizumab, HELLP
- Trial name
- CRUSH (NCT04725812)
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cedars-Sinai Medical Center
Preeclampsia
KW-3357 Study in Patients With Early Onset Severe Preeclampsia
The purpose of this study is to evaluate the efficacy of intravenous KW-3357 in patients with early-onset severe preeclampsia by comparing the prolongation days of pregnancy with that of placebo.
- Trial name
- NCT04182373
- Testing
- Antithrombin gamma, physiological saline
- Where
- 63 sites in Japan
- Volunteers
- 181 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Preeclampsia
Second Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Placentation Disorders
The current study included the singleton pregnancies (without history of previous risk factors), had their homocysteine measured as part of a serum-screening program in addition to uterine artery Doppler.
- Trial name
- NCT02854501
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cairo University
Severe Pre-eclampsia, Eclampsia
Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Management of Severe Preeclampsia and Eclampsia.
Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting.
- Trial name
- NCT06126068
- Testing
- Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia
- Where
- Nigeria
- Volunteers
- 120 people
- Sponsor
- Federal Teaching Hospital Abakaliki
Preeclampsia
Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial
This is a prospective, multicenter, randomized controlled, double-blind trial of three treatment arms: (1) aspirin 75 mg/day vs. (2) aspirin 150 mg/day vs.
- Trial name
- NCT05580523
- Testing
- 75 mg acetylsalicylic acid, 1.5g Metformin, 150 mg acetylsalicylic acid
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Preeclampsia
Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
The purpose of this study is to determine the prevalence of positive antiphospholipid antibodies among women with preeclampsia and to determine the effect of antiphospholipid antibodies on the severity of preeclampsia and the…
- Trial name
- NCT02699437
- Testing
- Testing for antiphospholipid antibodies
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mohamed Sayed Abdelhafez
Hypertensive Disorder of Pregnancy, Sleep Apnea, Obstructive
Positive Airway Pressure Treatment of Obstructive Sleep-disordered Breathing in Hypertensive Disorders of Pregnancy
The purpose of this study is to conduct a pilot randomized, controlled trial to evaluate the feasibility and obtain pilot outcome data for a subsequent definitive trial evaluating the effects of postitive airway pressure (PAP)…
- Trial name
- NCT03309826
- Testing
- Positive Airway Pressure, Nasal Dilator Strip
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Dr John Kimoff
Hypertension, Pregnancy-Induced
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide
The main purpose of this study is to learn if incorporating a loop diuretic such as furosemide along with labetalol in the routine management of postpartum gestational hypertensive disorders could lower the need for additional…
- Trial name
- NCT04343235
- Testing
- furosemide, labetalol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wright State University
Preeclampsia, Pregnancy Related
Use of Lumella-glycosylated Fibronectin for Diagnosis of Preeclampsia
women with symptoms of preeclampsia from antenatal clinic or triage will be offered Lumella test along with traditional blood tests. If Lumella test is positive which will be compared with the traditional blood test results.
- Conditions
- Preeclampsia, Pregnancy Related, Hypertension
- Trial name
- Lumella (NCT06085001)
- Testing
- Lumella finger prick blood test
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Croydon University Hospital
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Low Dose Calcium to Prevent Preeclampsia
The purpose of this study is to assess, in pregnant women with calcium-poor diets, what is the effectiveness of low-dose (500 mg/day) calcium supplements associated with an educational intervention, compared to the educational…
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Dietary Calcium Deficiency
- Trial name
- AMCAL (NCT02338687)
- Testing
- calcium, Educational sessions
- Where
- Brazil
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Mild Pre-eclampsia
Effect of Foot Reflexology on Preeclampsia
the aim of this study to investigate the effect of foot reflexology on mild preeclampsia during pregnancy
- Trial name
- NCT05888896
- Testing
- methyldopa tablets 250mg, methyldopa tablets 250mg + foot reflexology
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Preeclampsia, Intrauterine Growth Restriction
Fetal, Obstetrics and Reproduction Genomics
The purpose of this study is to determine the impact of a clinical screening strategy and genomic analysis of the factors involved in Placental Dysfunction (Preeclampsia and IUGR) in women of advanced maternal age undergoing…
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Placental Disease
- Trial name
- FORgenomics (NCT05720169)
- Testing
- Doppler ultrasound, Blood sample
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundación Ginemed
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Pre-Eclampsia
Evaluation of HALP Score in Preeclampsia
Preeclampsia is a serious condition that can occur during pregnancy and can pose problems for both the mother and the baby. It occurs in approximately 2-8% of all pregnancies globally and is caused by issues with blood vessels…
- Trial name
- NCT05816044
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Pre-Eclampsia, HELLP Syndrome
Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features
NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the setting of preeclampsia have not been well…
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Eclampsia
- Trial name
- NCT02911701
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Pre-Eclampsia, Stage 1 Hypertension
Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)
To determine if low dose aspirin reduces the incidence of hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome) in pregnant women with stage 1 hypertension and elevated blood…
- Conditions
- Pre-Eclampsia, Stage 1 Hypertension, Elevated Blood Pressure
- Trial name
- NCT04402385
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University