Clinical trials: Pre Eclampsia
Pre-Eclampsia
Low Dose Aspirin for Prevention of Early Pregnancy Loss
Preeclampsia is a pregnancy-specific, multisystem disorder affecting 3% to 8% of pregnancies and remains a significant cause of maternal and neonatal morbidity and mortality worldwide.
- Trial name
- NCT06261203
- Testing
- Aspirin
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Egymedicalpedia
Pre-eclampsia, Pregnancy, High Risk
Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia
The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks'…
- Conditions
- Pre-eclampsia, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- PARROT (NCT02881073)
- Testing
- Maternal plasma PlGF quantification
- Where
- 7 sites in Ireland
- Volunteers
- 2,313 people
- Sponsor
- Irish Centre for Fetal and Neonatal Translational Research
Pre-Eclampsia, Hypertension
Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women
Whole blood sample procurement study from pregnant women with signs and symptoms of Preeclampsia.
- Conditions
- Pre-Eclampsia, Hypertension, Proteinuria in Pregnancy, Thrombocytopenia
- Trial name
- NCT03767803
- Testing
- Non-interventional study
- Where
- 24 sites in United States
- Volunteers
- 344 people
- Sponsor
- Progenity, Inc.
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Pregnancy, High Risk, Pre-Eclampsia
Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Raised blood pressure is a common problem in pregnancy. Raised blood pressure and pre-eclampsia affect about one in ten women and are a major cause of death and premature birth in the United Kingdom and worldwide.
- Conditions
- Pregnancy, High Risk, Pre-Eclampsia, Hypertension, Hypertension, Pregnancy-Induced
- Trial name
- BUMP (NCT03334149)
- Testing
- Self-Monitoring of Blood Pressure
- Where
- 13 sites in United Kingdom
- Volunteers
- 3,042 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Postpartum Preeclampsia
Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth…
- Trial name
- PREDiCT-NPL (NCT07185204)
- Testing
- Early detection and management of postpartum preeclampsia bundle
- Where
- 2 sites in United States, Nepal
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Hypertension, Preeclampsia
The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
The objective of this study is to demonstrate that urapidil is not inferior to nicardipine for the treatment of hypertension associated with preeclampsia (PE) and that it is better tolerated.
- Trial name
- Uranic (NCT02558023)
- Testing
- Urapidil, Nicardipine
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Gestational Diabetes, Pre-Eclampsia
Body Fat Index for Obstetric Risk Stratification
Primary Outcome:- GDM Diagnosis Secondary Outcomes:- Pre-eclampsia diagnosis. Cesarean section delivery due to labor dystocia defined as protracted or arrested progress of labor using labor partogram.
- Conditions
- Gestational Diabetes, Pre-Eclampsia, Labour Dystocia
- Trial name
- BFIors (NCT05533996)
- Testing
- ultrasound
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pre-Eclampsia, Asymptomatic Bacteriuria
Prevalence of Asymptomatic Bacteriuria Among Pregnant Women With Pre-eclampsia in Women Health Hospital Assiut University
Pre-eclampsia is a hypertensive disorder of pregnancy that can lead to significant health complications for both the mother and the fetus.
- Trial name
- NCT07866196
- Volunteers
- 129 people
- Sponsor
- Assiut University
Pre-Eclampsia
Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia?
The purpose of the study is to test the hypothesis that a short course of atorvastatin can improve vascular function in women with a history of preeclampsia, compared to placebo.
- Trial name
- PVS3 (NCT01278459)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Oxford
Preeclampsia, Pregnancy
Analgesia After Cesarean Section
Magnesium sulphate is the first line therapy for the management of preeclampsia and eclampsia in obstetrics. Perioperative administration of magnesium sulphate has been proved to be an effective as an analgesic adjuvant.
- Trial name
- NCT01360060
- Testing
- Magnesium Sulphate
- Where
- South Korea
- Volunteers
- 503 people
- Sponsor
- Seoul National University Bundang Hospital
Preeclampsia, Gestational Hypertension
Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease.
- Trial name
- IMPACT-HT (NCT07041281)
- Testing
- spironolactone 25 mg orally once daily
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- Massachusetts General Hospital
Preterm Birth, Preeclampsia
Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia
The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the…
- Trial name
- PRIME (NCT06281262)
- Testing
- Peripheral blood collection, Swab sample collection
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- General University Hospital, Prague
Preeclampsia, Preterm Birth
The Effect of Prematurity and Hypertensive Disorders of Pregnancy on Offspring Cardiovascular Health
The purpose of this study is to investigate whether exposure to hypertensive disorders of pregnancy and/or a preterm birth results in alterations in the cardiovascular system during infancy.
- Trial name
- EPOCH (NCT01888770)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
Sleep Disordered Breathing, Obstructive Sleep Apnea
Sleep Disordered Breathing and Gestational Hypertension
Sleep disordered breathing (SDB) is a common problem in the adult population. By conservative estimates, 4% of the adult female population has SDB.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Gestational Hypertension, Preeclampsia
- Trial name
- NCT00757718
- Testing
- CPAP, Oral Appliance
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Saskatchewan
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Pre-Eclampsia
Evaluation of Neutrophil/Lymphocyte Ratio ,Platelet/Lymphocyte Ratio and CRP as Markers of Severity of Pre-eclampsia
Evaluation of neutrophil/lymphocyte ratio, Platelet /lymphocyte ratio and CRP as markers of severity of Pre-eclampsia
- Trial name
- NCT03630276
- Testing
- Neutrophil/lymphocyte ratio, Platelet /lymphocyte ratio and CRP
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pre-Eclampsia, Obesity; Endocrine
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies
The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric…
- Trial name
- CTRP (NCT03650790)
- Testing
- Blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Hypertension, Pregnancy-Induced, Pre-Eclampsia
Early Vascular Adjustments During Hypertensive Pregnancy
Paradoxical fetal and maternal results of studies have led to inconsistent use of antihypertensive drugs or no treatment at all in mild to moderate gestational hypertension in the Netherlands.
- Trial name
- EVA (NCT02531490)
- Testing
- Labetalol, Nifedipine, Methyldopa
- Where
- Netherlands
- Volunteers
- 368 people
- Sponsor
- Maastricht University Medical Center
Pregnancy, Preeclampsia
Effects of Progressive Muscle Relaxation Exercise and Finger Grip Exercise on Stress, Anxiety, Fatigue, Sleep Quality, and Physiological Parameters in Pregnant Women With Preeclampsia
The aim of this study is to examine the effects of progressive muscle relaxation exercise and finger grip exercise on stress, anxiety, sleep quality, fatigue and physiological parameters in preeclamptic pregnant women.
- Trial name
- NCT07630623
- Testing
- Progressive Muscle Relaxation Exercise, Finger Grip Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hatice Nur Nefes Pala