Clinical trials: Pre Eclampsia
Preeclampsia
Aspirin for Prevention of Preeclampsia
Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and…
- Trial name
- NCT03726177
- Testing
- aspirin 162 mg, aspirin 81 mg
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Aswan University Hospital
Preeclampsia
PP13 and Doppler Study to Predict Preeclampsia
Assessment of biochemical and sonographic marker to predict the risk for developing preeclampsia Among biochemical markers are serum level of Placental Protein 13 (PP13) and Placenta Growth factor (PIGF).
- Trial name
- NCT00928213
- Testing
- Progesterone, Low molecular weight Heparin, No Drug
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Ben-Gurion University of the Negev
Preeclampsia
LMWH to Prevent Preeclampsia and Fetal Growth Restriction
The objective of this trial will be to determine whether prophylactic low-molecular weight heparin therapy in pregnant women with the heterozygous Factor V Leiden and G20210A prothrombin gene mutations thrombophilia and a history…
- Trial name
- NCT00260520
- Testing
- Dalteparin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florence
Medication Adherence, Preeclampsia
Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia
There are data showing that a majority of pregnant women may not be accurately identified as high risk through screening and therefore, not receiving prophylactic low dose aspirin as recommended.
- Trial name
- NCT04797949
- Testing
- Low-dose aspirin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Postpartum Preeclampsia
Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies.
- Trial name
- NCT03449277
- Testing
- Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Hossam Ahmed Abd Ellah
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the efficacy and safety of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556357
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 138 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypertension, Cardiovascular Diseases
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
The purpose of this study is to understand more about why women who have had hypertensive pregnancies may be at increased risk of high blood pressure and why these women are often at increased risk of heart and blood vessel…
- Conditions
- Hypertension, Cardiovascular Diseases, Cerebrovascular Disorders, Vascular Diseases
- Trial name
- HELPFUL (NCT06187012)
- Testing
- Hypertensive pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Detection of Preeclampsia Complications
Pre-eclampsia and Biochemical Markers
In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who…
- Trial name
- PET (NCT02665897)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Preeclampsia
Predicting Late-onset Preeclampsia at 10-14 Weeks of Pregnancy
The aim of this study is to make it easier to predict late-onset preeclampsia at 11-14 weeks of pregnancy. This will be done by measuring certain proteins in the mother's blood together with obtaining the mother's medical…
- Trial name
- NCT04075708
- Where
- Denmark
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Preeclampsia
Study of Maternal and Fetal Cardiovascular Function in Hypertensive States of Pregnancy
The pharmacological treatment strategy is then tailored to the underlying hemodynamic phenotype of each patient. That is, rather than applying a one-size-fits-all treatment for all patients, therapy is tailored to the specific…
- Trial name
- CARDIAC-OAT (NCT06858345)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia
Management of Hypertension in the Early Postpartum: a Randomized Controlled Trial
In hypertensive mothers, it is common in clinical practice to substitute methyldopa for another medication, such as captopril, immediately after delivery, which may, as a consequence, cause a rebound effect or an initial lack of…
- Conditions
- Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia, Hypertension
- Trial name
- NCT04835233
- Testing
- Methyldopa 250 MG
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Federal University of Paraíba
Preeclampsia, Vitamin A Deficiency
The Correlation Between Vitamin A / E Levels and Preeclampsia
Vitamin A (VA) and vitamin E (VE) are fat-soluble vitamins and indispensable substances in life activities. VA plays an important role in visual function, normal formation and development of epithelial cells, development and…
- Conditions
- Preeclampsia, Vitamin A Deficiency, Vitamin E Deficiency
- Trial name
- NCT03971604
- Testing
- Vitamin A, Vitamin E
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Preeclampsia
Progesterone in Expectantly Managed Early-onset Preeclampsia
Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks postpartum
- Trial name
- NCT04077853
- Testing
- 17 Hydroxyprogesterone Capronate
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Preeclampsia Awarness
Improve Awarness of Preeclampsia Among Pregnant Women
Preeclampsia is a major pregnancy-related hypertensive disorder and a leading cause of maternal and perinatal morbidity and mortality worldwide, particularly in developing regions.
- Trial name
- NCT07805239
- Testing
- Questionnaire
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aya Magdy Mohamed Amin
Pre-eclampsia Aggravated
Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients
Background: The aim of this prospective study was to evaluate the effect of magnesium on the reversal of rocuronium-induced neuromuscular block by sugammadex.
- Trial name
- NCT01972659
- Testing
- Magnesium Sulphate, sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University
Preeclampsia, Eclampsia
uChek Pilot Study for Urinalysis in the Antenatal Care Setting
A prospective observational study to test the feasibility of smartphone enabled uChek urinalysis device to detect biomarkers (protein, microalbumin and protein:creatine ratio) in urine, indicative of preeclampsia/eclampsia at…
- Conditions
- Preeclampsia, Eclampsia, Pregnancy, Proteinuria
- Trial name
- uChekBangla (NCT02256995)
- Testing
- uChek
- Where
- Bangladesh
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Maternova Research
Mild Pre-eclampsia, Severe Pre-eclampsia
Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach
Acid/base imbalances are not well understood in pre-eclamptics, and better tools are needed to allow a thorough and meaningful evaluation.
- Trial name
- NCT02164370
- Where
- 2 sites in United States, South Africa
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Preeclampsia
Maternal Serum Stathmin-1 Levels in Preeclampsia
The goal of this observational study is to investigate maternal serum Stathmin-1 levels in pregnancies affected by preeclampsia compared to healthy gestations. The main questions it aims to answer are: 1.
- Trial name
- MSSLP (NCT06481683)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Burak Yücel Special Clinic
Abortion, Spontaneous, Pregnancy Complications
Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy
Studies have demonstrated a relationship between subclinical hypothyroidism and obstetrics complications like preterm delivery, pre-eclampsia, placental abruption and stillbirth.
- Conditions
- Abortion, Spontaneous, Pregnancy Complications, Subclinical Hypothyroidism
- Trial name
- GravThyr (NCT01335802)
- Where
- Denmark
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Naestved Hospital