Clinical trials: Pre-Diabetic
Fibromyalgia, Painful Diabetic Peripheral Neuropathy
Examination of Pregabalin Access for Treatment of Indicated Pain Disorders: the ExPAND Study
The investigators hypothesize that fibromyalgia (FM) and painful diabetic peripheral neuropathy (pDPN) patients with access restrictions on pregabalin will lead to higher healthcare resource use and cost compared to patients…
- Trial name
- NCT01280747
- Testing
- prior authorization, no prior authorization
- Where
- 17 sites in United States
- Volunteers
- 42 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glucose Intolerance
The Effect of Momordica Charantia Supplementation on Blood Glucose Levels
The study is a randomized, cross-over, double blind, controlled trial in which study participants will receive two 4-week interventions with a washout period of 4 weeks between interventions.
- Trial name
- Bitter-sweet (NCT04090788)
- Testing
- dried bitter-gourd supplements, dried cucumber supplements
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Wageningen University and Research
Type 2 Diabetes, Obesity
Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy
The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis.
- Trial name
- NCT01820273
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lund University
Prediabetes / Type 2 Diabetes
A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes
This is a randomized, single-blind, controlled, parallel clinical trial to examine the efficacy and safety of AMPK Charge+® with and without use of semaglutide on glycemic response in adults with prediabetes or Type 2 Diabetes.
- Trial name
- NCT07195994
- Testing
- AMPK Charge+®, AMPK Charge+® with semaglutide
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- QuickSilver Scientific
Pre Diabetes
Glycemic Metrics and Patterns in People With and Without Prediabetes
The FreeStyle Libre 3 Continuous Glucose Monitoring (FSL3) System is used to characterize the glycemic profiles of people with and without a prediabetes diagnosis.
- Trial name
- PREMAP (NCT06921902)
- Testing
- FreeStyle Libre 3
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Abbott Diabetes Care
Fatty Liver, Overweight/Obesity
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism
The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases.
- Conditions
- Fatty Liver, Overweight/Obesity, Prediabetes/Type2 Diabetes Mellitus, Hypogonadism, Male
- Trial name
- Test2Func (NCT03851627)
- Testing
- Testosterone Undecanoate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Alexandra Kautzky-Willer
CKD Progression
Hyperuricemia as Early Indication of CKD Progressing in Prediabetic
Chronic kidney disease (CKD) is a major global health problem, and hyperuricemia has emerged as both a consequence and a potential driver of its progression.
- Trial name
- NCT07199205
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus, Type 2, PreDiabetes
18F-FDOPA PET/CT Imaging in Patients Undergoing Metabolic Surgery
The aim of the study is to compare the endocrine function of pancreas between pre and post metabolic surgery in patients with type 2 diabetes or prediabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03821961
- Testing
- Metabolic Surgery
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
Type 2 Diabetes, Obesity
Energy Flux and Fat Oxidation Using Low and High Glycaemic Index Foods
Purpose: This study is carried out to determine the effect of GI on 24 hour blood glucose profiles and energy regulation in Asians when fed a normal diet modulated with sweeteners.
- Conditions
- Type 2 Diabetes, Obesity, PreDiabetes
- Trial name
- NCT03031886
- Testing
- low glycaemic index intervention, high glycaemic index intervention
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Weight Loss, Obesity
A Study to Assess the Effect of a Normal vs. High Protein Diets in Carbohydrates Metabolism in Obese Subjects With Diabetes or Prediabetes
The objective of the study is to assess the effect of low-calorie diets with normal (18%) vs. high (35%) protein (mainly coming from animal source) composition on body weight and carbohydrates metabolism in overweight and obese…
- Conditions
- Weight Loss, Obesity, Diabetes, Diet, Reducing
- Trial name
- NCT02559479
- Testing
- Weight loss interventional study with a low-calorie 18%-protein diet, Weight loss interventional study with a low-calorie 35%-protein diet
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Overweight and Obesity, Pre-diabetes
SWITCH Diets Study: Self-monitoring With Internet Technology to Choose Healthy Diets
The goal of the Self-monitoring With Internet Technology to Choose Healthy Diets (SWITCH) study is to examine a 12-week remotely delivered program designed to help adults adopt a healthy dietary lifestyle and lose weight in a…
- Trial name
- SWITCH (NCT06245369)
- Testing
- learning modules (within app), SWITCH app (self-regulation features) - Experimental, SWITCH app (self-regulation features) - Comparator
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Prediabetes
Mechanism Study of Metabolic Response and Health Benefit Induced by Exercise
This study is a single-arm, self-control, single-center study to investigate the mechanism under exercise inducing metabolic response and health benefit.
- Trial name
- NCT06633653
- Testing
- exercise intervention
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Obesity
Incretin Effect in People With Impaired Fasting Glucose
Regulation of endogenous glucose production (EGP) and insulin secretion are major actions of glucagon-like peptide-1 (GLP-1). Determining whether alterations in GLP-1 may contribute to abnormal EGP and insulin secretion in people…
- Trial name
- 1651 (NCT00795275)
- Testing
- Sitagliptin Phosphate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prediabetes, Type 2 Diabetes
BETA: Study in Prediabetes Type 2 Diabetes
This study is testing the feasibility of using non-invasive, remote digital tools including continuous glucose monitors (CGMs) and the Oura Ring to predict the function of beta-cells, the cells in the pancreas that secrete…
- Trial name
- BETATrack (NCT07598773)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- 4YouandMe
PreDiabetes, Diabetes Mellitus, Type 2
Acceptance and Commitment Therapy Principles for Diabetes Prevention
The investigators will evaluate whether a brief intervention (i.e. a workbook and video presenting educational information and activities materials for diabetes prevention) that incorporates principles drawn from focused…
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Diabetes, Diabetes type2
- Trial name
- NCT05260983
- Testing
- Diabetes Prevention Education and Acceptance and Commitment Therapy, Diabetes Prevention Education Only
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Oregon
Gum Disease, Prediabetes
Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by AI
Prediabetes is an intermediate stage before the development of diabetes, characterized by elevated blood glucose levels but lower than the diagnostic criteria of diabetes and is associated with multiple long-term complications.
- Trial name
- NCT06980701
- Testing
- AI OHI group, Dental professionals OHI group
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Enterovirus Infection, Type 1 Diabetes
Live Enterovirus Vaccine and Type 1 Diabetes
Enterovirus infections may either increase or decrease the risk of type 1 diabetes depending on the age of infection and the type of enterovirus in question.
- Conditions
- Enterovirus Infection, Type 1 Diabetes, Prediabetic State
- Trial name
- NCT02961595
- Testing
- Oral Polio Vaccine (OPV)
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Tampere University
Diabetic Macular Edema, Cataract
Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification
The primary objective of this study is to compare the efficacy of antecedent intravitreal anti-vascular endothelial growth factor therapy vs.
- Trial name
- STAMP (NCT03832179)
- Testing
- Bevacizumab, Ranibizumab, Aflibercept
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bay Area Retina Associates
Diabetes in Adolescence, PreDiabetes
The Efficacy of AP029 Mix in Patients With Impaired Carbohydrate Metabolism
The aim of the study is to demonstrate that a daily supplementation of AP029 Mix: I) has a positive effect on reducing side effects of metformin, while enhancing the therapeutic effect of metformin; II) normalizes prediabetes…
- Trial name
- NCT05994586
- Testing
- AP029 mix
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- AronPharma Sp. z o. o.