Clinical trials: Pre-Eclampsia, Severe
Preeclampsia Severe, Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter in Pre-Eclamptic Parturient Receiving Magnesium Sulfate Combined With Dexmedetomidine
Dexmedetomidine was reported to effectively reduce cerebral metabolism and ICP by decreasing cerebrospinal fluid pressure in patients with cerebral tumors or head injuries that require craniotomy.
- Trial name
- NCT05610774
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Pressor Response
Lignocaine Nebulization for Attenuation of Intubation Stress Response
To study the effect of lignocaine nebulization on attenuation of the pressor response during induction and emergence of anesthesia in patients with severe pre-eclampsia
- Trial name
- NCT04441073
- Testing
- Lignocaine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hypertension
Prevention of Severe Postpartum Hypertension
The purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours…
- Trial name
- NCT02450773
- Testing
- Furosemide, Potassium chloride
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Preeclampsia
Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome
Pre-eclampsia seems to be associated with a four to five times increase risk of later microalbuminuria and CKD which might suggest a possible direct renal damage from pre-eclampsia
- Trial name
- NCT03891394
- Testing
- Human epididymis protein 4
- Volunteers
- 110 people
- Sponsor
- Ain Shams University
Antithrombin III Deficiency
Atenativ Effect on Uterine Blood Flow and Preeclampsia
The study will be an open controlled pilot study of 6 patients with early-onset severe preeclampsia. Patients will receive Atenativ in addition to conventional therapy The patients will be followed up within the study until three…
- Trial name
- NCT02278575
- Testing
- Atenativ
- Where
- Sweden
- Sponsor
- Vastra Gotaland Region
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia Severe
Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patients
It had been shown that high percentage of severe preeclampsia patients got a high cerebral perfusion pressure (CPP) due to abnormal autoregulation of cerebral blood vessels with associated endothelial dysfunction and disrupted…
- Trial name
- NCT03210350
- Testing
- Optic nerve sheath diameter
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Corniche Hospital
Preeclampsia
Aggressive Versus Expectant Management of Severe Preeclampsia Remote From Term
How best to manage preeclampsia remote from term is controversial because of conflicting maternal and neonatal risks. Gestational age is the most important determinant of neonatal outcome.
- Trial name
- MEXPRE-Latin (NCT01164852)
- Testing
- Delivery
- Where
- 8 sites in Ecuador, Guatemala and 4 more
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Preeclampsia
Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia
The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly understood pathophysiology of preeclampsia.
- Trial name
- NCT00719654
- Where
- United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Preeclampsia With Severe Features
Use of Cheetah® Cardiac Monitoring System to Guide Discontinuation of Magnesium Sulfate in Women With Severe Preeclampsia
This is a single site pilot randomized, controlled, trial randomizing patients with PE with severe features to one of 2 groups: 24 hours of postpartum magnesium sulfate (current arbitrary standard of care) Using the Cheetah®…
- Trial name
- NCT04474704
- Testing
- Cheetah® non-invasive cardiac monitoring system, Standard of care
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Preeclampsia With Severe Features
Acute Labetalol Use in Preeclampsia
The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's body-mass index, will be more effective at controlling severe hypertension…
- Trial name
- ALERT (NCT03872336)
- Testing
- Experimental labetalol dose, Current standard of care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Albany Medical College
Severe Pre-eclampsia
Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery
Prospective randomized single blind trial. Study population are women diagnosed with severe pre-eclampsia during singleton pregnancy, between 24+0 weeks and 41+6 weeks gestational age.
- Trial name
- NCT02314286
- Testing
- Rosuvastatin
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Preeclampsia, Preeclampsia Postpartum
Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound
This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction.
- Conditions
- Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
- Trial name
- PPPOCUS (NCT07167862)
- Testing
- Butterfly iQ3 ultrasound system for determination of postpartum volume status, Oral furosemide, Intravenous furosemide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Severe Preeclampsia
Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia
Preeclampsia is commonly viewed as one of the hypertensive pregnancy disorders, which cover a spectrum of clinical presentations from chronic hypertension ( hypertension occurring prior to 20 weeks of gestation) and gestational…
- Trial name
- NCT03164304
- Testing
- Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Assiut University
Severe Preeclampsia
Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia
This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery.
- Trial name
- NCT07861685
- Testing
- Furosemide and Potassium
- Where
- Pakistan
- Volunteers
- 434 people
- Sponsor
- Lady Reading Hospital, Pakistan
Preeclampsia, Acute Kidney Injury
Accuracy of Venous Excess Ultrasound Score at Hospital Admission to Predict Acute Kidney Injury
To evaluate diagnostic accuracy of venous excess ultrasound score to predict acute kidney injury
- Trial name
- NCT07040696
- Testing
- Venous excess ultrasound score (VEXUS)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Severe Pre-Eclampsia, Antepartum
Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in pre eclamptic pregnant patients Design: Randomised control trial SETTING: Department Obstetrics \& gynaecology, Services Hospital…
- Trial name
- NCT03325348
- Testing
- Nifedipine 10 mg, Labetalol
- Where
- Pakistan
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Hypertension, Preeclampsia
The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
The objective of this study is to demonstrate that urapidil is not inferior to nicardipine for the treatment of hypertension associated with preeclampsia (PE) and that it is better tolerated.
- Trial name
- Uranic (NCT02558023)
- Testing
- Urapidil, Nicardipine
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Preeclampsia, Antiphospholipid Syndrome
Antiphospholipid Antibodies and Early Severe Preeclampsia.
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and…
- Trial name
- NCT01538121
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama