Clinical trials: Pre-eclampsia
Preeclampsia Postpartum, Adverse Pregnancy Outcomes
A Community Health Worker Intervention to Address Adverse Pregnancy Outcomes
United States maternal mortality and preterm birth rates are among the highest among high-income countries due in part to a combination of racial, regional and socioeconomic disparities in access to care and overall health.
- Trial name
- AW2H (NCT06353256)
- Testing
- usual postpartum care, usual postpartum care + community health worker intervention
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pre-Eclampsia, Gestational Hypertension
Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide
Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03298802
- Testing
- Hydrochlorothiazide 50mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 453 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hypertensive Disorder of Pregnancy, Pre-Eclampsia
Optimal Blood Pressure Treatment Thresholds Postpartum
The objective of this research project is to conduct a single-site pilot trial within our institution's clinical remote blood pressures (BP) management program to assess the feasibility and effect of tight blood pressure control…
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia
- Trial name
- NCT06069102
- Testing
- Usual care, Tight blood pressure control
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Alisse Hauspurg
Severe Preeclampsia
Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
This study evaluates the use of AMAG-423 (Digoxin Immune Fab) in addition to expectant management in the treatment of severe preeclampsia as compared to placebo.
- Trial name
- NCT03008616
- Testing
- AMAG-423 (digoxin immune fab)
- Where
- 18 sites in United States, Poland and 1 more
- Volunteers
- 58 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia
Postpartum Hypertension Study
The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.
- Conditions
- Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia, Pregnancy-Induced Hypertension in Postpartum, Hypertensive Emergency
- Trial name
- NCT05139238
- Testing
- Labetalol, Nifedipine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University
Preeclampsia, Maternal Hypertension
PROtecting Maternal Brains From Injury and Stroke
The purpose of this study is to test a new approach to blood pressure management in postpartum preeclampsia. There will be two groups of patients in this early stage single center trial.
- Trial name
- PROMIS (NCT05726279)
- Testing
- NIRS based personalized blood pressure management
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Columbia University
Preeclampsia, Obstetric Labor Complications
Pravastatin to Prevent Preeclampsia
This study is a double-blind randomized placebo-controlled trial of 1,550 high-risk women to assess whether daily treatment with pravastatin administered early in pregnancy reduces the rate of a composite outcome of preeclampsia…
- Conditions
- Preeclampsia, Obstetric Labor Complications, Hypertension in Pregnancy
- Trial name
- Pravastatin (NCT03944512)
- Testing
- Pravastatin
- Where
- 12 sites in United States
- Volunteers
- 102 people
- Sponsor
- The George Washington University Biostatistics Center
Pre-Eclampsia
Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia
Endothelial dysfunction and defective placental vascularization are hypothesized to be significant causes of preeclampsia. In preeclampsia, due to vascular endothelial dysfunction, vasoconstriction and platelet activation can…
- Trial name
- ASPERIN (NCT03893630)
- Testing
- Acetylsalicylic Acid 81 mg, Acetylsalicylic Acid 162 mg, Control
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- John O'Brien, MD
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Preeclampsia
Low Doses of Aspirin in the Prevention of Preeclampsia
Preeclampsia (PE) is a morbid and potentially lethal complication of pregnancy and is more common in women with specific risk factors.
- Trial name
- ASAPP (NCT04070573)
- Testing
- acetylsalicylic acid
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Weill Medical College of Cornell University
Gestational Hypertension, Preeclampsia
App-based Remote Blood Pressure Monitoring
Remote postpartum blood pressure monitoring program with text messages has been shown to increase adherence to recommended postpartum blood pressure checks among those with hypertension at discharge from birth hospitalization…
- Conditions
- Gestational Hypertension, Preeclampsia, Chronic Hypertension Complicating Pregnancy
- Trial name
- NCT05595629
- Testing
- App-based remote blood pressure monitoring, text-message based remote blood pressure monitoring
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Hypertensive Disorder of Pregnancy
Remote BP Monitoring in the PP Period
The purpose of this study is to trial remote patient monitoring (RPM) in the postpartum hypertensive population in a randomized control design, with an aim to increase the number of blood pressure measurements taken during the…
- Trial name
- NCT03728790
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Columbia University
Neurodevelopmental Abnormality
ASPIRIN: Neurodevelopmental Follow-up Trial
A total of 620 children will be enrolled in this study from six sites in sub-Saharan Africa, South Asia, and Latin America. Half of the children's mothers will have taken aspirin and half will have taken placebo.
- Trial name
- NCT04888377
- Testing
- Aspirin
- Where
- 14 sites in United States, Democratic Republic of the Congo and 4 more
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Preeclampsia, Preeclampsia Severe
Nudge to Drive Transitions of Care
Hypertensive disorders of pregnancy (HDP) are stress tests which may identify women at high risk of future cardiovascular disease (CVD), the leading cause of death among women.
- Conditions
- Preeclampsia, Preeclampsia Severe, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- REMIND (NCT04660032)
- Testing
- Nudge
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Pennsylvania
Pre-Eclampsia
FACT Biomarker Subgroup Analysis
The FACT Biomarker Subgroup Analysis is a pilot study of mothers who participated in the Folic Acid Clinical Trial (FACT, NCT01355159).
- Trial name
- NCT03981029
- Testing
- 4.0mg Folic Acid received through participation in FACT (NCT01355159)
- Where
- 4 sites in Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pre-Eclampsia, Hypertension in Pregnancy
Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
To compare the incidence of preeclampsia in obese pregnant women (BMI greater than 30) with a singleton gestation at less than 20 weeks and either a history of preeclampsia in a prior pregnancy or stage I hypertension or…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Obesity
- Trial name
- ASPREO (NCT03961360)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The University of Texas Health Science Center, Houston
Preeclampsia
The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia
Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is not known.
- Trial name
- NCT03735433
- Testing
- 162mg aspirin dose
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Ohio State University
Pre-Eclampsia, Hypertension in Pregnancy
Furosemide vs. Placebo for Severe Antepartum Hypertension
Primary objective: To determine whether the addition of intravenous furosemide with usual antihypertensives is associated with a reduction in mean systolic blood pressure from baseline compared to treatment with placebo plus…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications, Hypertension, Pregnancy-Induced
- Trial name
- NCT04615624
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Melanie Maykin, MD
Preeclampsia, Severe Preeclampsia
Complement Regulation to Undo Systemic Harm in Preeclampsia
This is a Phase II, single arm, open-label study to determine if treatment with eculizumab prolongs pregnancy compared to historical controls in women with preeclampsia between 23-30 weeks gestation.
- Conditions
- Preeclampsia, Severe Preeclampsia, Eculizumab, HELLP
- Trial name
- CRUSH (NCT04725812)
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cedars-Sinai Medical Center