Clinical trials: Pre-operative
Locally Advanced Gastric Adenocarcinoma
Adebrelimab Combined With SOX Regimen in Preoperative Neoadjuvant Transformation Therapy for Locally Advanced Gastric Adenocarcinoma
Abstract Objective: Adebrelimab is a PD-L1 inhibitor. The aim of this trial is to evaluate the safety and efficacy of adebrelimab combined with SOX regimen for preoperative neoadjuvant therapy in locally advanced gastric…
- Trial name
- NCT06192186
- Testing
- Adebrelimab combined with SOX regimen
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Yang Jianjun, PhD
Breast Cancer Invasive
Neoadjuvant Treatment of Triple-Negative Breast Cancer with Stereotactic Radiotherapy, PD-1 Monoclonal Antibody, and Chemotherapy
The primary aim is to evaluate the efficacy of neoadjuvant SBRT combined with PD-1 monoclonal antibody and chemotherapy in patients with triple-negative breast cancer, with the endpoint being the pCR rate-defined as the…
- Trial name
- NCT06691594
- Testing
- neoadjuvant SBRT combined with PD-1 monoclonal antibody and chemotherapy
- Volunteers
- 20 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Anxiety, Cesarean Section Complications
The Effect of Pre-operative Videotape Before a Planned Cesarean Section on Anxiety Level
The study aim is to examine the relationship between providing information to women prior to elective cesarean delivery and anxiety levels around surgery. the patients will be assigned into two groups - intervention and control.
- Conditions
- Anxiety, Cesarean Section Complications, Pain, Postoperative, Analgesia
- Trial name
- NCT04177966
- Testing
- pre-prepared video describing the cesarean surgery, general information
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Stomach Neoplasm, GastroEsophageal Cancer
PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy
Although the incidence of gastric cancer has been substantially declining for several decades, it is still the sixth most common cancer and the fourth most frequent cause of cancer death worldwide.
- Conditions
- Stomach Neoplasm, GastroEsophageal Cancer, Adenocarcinoma, Locally Advanced Cancer
- Trial name
- PREACT (NCT03013010)
- Testing
- Tegafur-Gimeracil-Oteracil Potassium, Chemoradiotherapy, Gastric resection
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Cancer Hospital, China
Newly Registered Patients for Primary Liver Transplantation
Effects of Preoperative Long-Term Immunonutrition in Patients Listed for Liver Transplantation
Patients with endstage liver disease characteristically are malnourished which is associated with poor outcome. Formulas enriched with arginine,ω3 fatty acids, and nucleotides potentially improve their nutritional status.
- Trial name
- PROUD (NCT00495859)
- Testing
- Immunonutrition, food for special medical purposes (FSMP)
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- Heidelberg University
Post Partum Hemorrhage
Misoprostol Before and After Cesarean Section
comparison of the effect of misoprostol before and after cesarean on the blood loss
- Trial name
- NCT03463070
- Testing
- rectal misoprostol 600mg
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- sarah mohamed hassan
Glioma, Brain Neoplasms
Susceptibility-Weighted Imaging in Preoperative Grading of Cerebral Gliomas
Gliomas are the most common primary brain tumors in adults. Determining whether a glioma is low-grade or high-grade before surgery is essential for surgical planning, choosing treatment pathways, and determining prognosis.
- Conditions
- Glioma, Brain Neoplasms, Cerebral Glioma
- Trial name
- NCT07813741
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hip Arthropathy, Malnutrition; Anemia
Nutritional Status and Its Modifications After Hip Replacement
Data literature lacks of evidence concerning the variation of the nutritional status in patients undergoing hip surgery, thus preventing an effective application a nutritional support program.
- Conditions
- Hip Arthropathy, Malnutrition; Anemia, Frail Elderly Syndrome
- Trial name
- NCT03981354
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Prostate Cancer, Radiation Toxicity
Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer
RATIONALE: Gathering information about the Gleason score, prostate-specific antigen (PSA) level, and cancer stage from patients who have undergone radiation therapy for prostate cancer may help doctors predict how patients…
- Trial name
- NCT00769223
- Testing
- medical chart review, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 3,561 people
- Sponsor
- University of California, San Francisco
Sarcoma of Soft Tissue, Sarcoma
Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas
Based upon the preliminary data derived from first SCOPES clinical trial and the results of patients treated during the recent COVID-19 pandemic, patients with soft tissue sarcomas (STS) can be preoperatively irradiated in a…
- Conditions
- Sarcoma of Soft Tissue, Sarcoma, Sarcoma, Soft Tissue
- Trial name
- SCOPES II (NCT07071727)
- Testing
- Preoperative radiotherapy
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- The Netherlands Cancer Institute
Acute Pain
Psychosocial Support for Pre-operative Pain and Distress
The purpose of this randomized study is to determine the impact of three different types of psychosocial support delivered by mental health professionals to pre-operative joint replacement patients.
- Trial name
- Mind-Body JRA (NCT03665727)
- Testing
- Mindfulness, Suggestion, Psychoeducation
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Utah
Hypovolemia
Echocardiographic Assessment of Volume Variation Secondary to Preoperative Fasting
The primary objective of this study is to demonstrate that preoperative fasting does not increase the rate of lowered blood volume (defined by a variation of 15% ΔITV during a leg lift) in patients undergoing surgery.
- Trial name
- NCT01258361
- Testing
- echocardiography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Breast Cancer
Patient-Reported Outcome and Safety Between Preoperative and Postmastectomy Radiotherapy in DIEP Flap Reconstruction
This study is the first prospective randomized study assessing the patient-reported outcomes and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate…
- Trial name
- CAPPELLA (NCT05512286)
- Testing
- Preoperative radiotherapy, Postmastectomy radiotherapy
- Where
- 6 sites in China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Preoperative Evaluation, Preoperative Anxiety
Comparison of the Effects of Preoperative Anesthesia Evaluation on Preoperative Anxiety Using Anxiety Scales and Evaluation of Patient Satisfaction
To measure the degree of preoperative anxiety with the STAIT, APAIS and VAS anxiety scales before and after the preoperative anesthesia evaluation in patients who applied for preoperative anesthesia evaluation for elective…
- Conditions
- Preoperative Evaluation, Preoperative Anxiety, STAI, Visual Analogy Scala
- Trial name
- NCT06849583
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Naime Yalçın
Pain, Postoperative, Atrial Fibrillation
BRS and Outcomes in Cardiothoracic Surgery
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how likely you are to suffer…
- Conditions
- Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
- Trial name
- NCT03243279
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Thoracic, Colorectal Disorders
Evaluating Intuitive 3D Models in Preoperative Surgical Planning for Thoracic and Colorectal Procedures.
The Study Objective: To evaluate the clinical utility of a 3D model with 2D CT/MRI scans during simulated preoperative surgical planning of open, laparoscopic, or robotic-assisted anatomic lung resection (segmentectomy…
- Trial name
- ISI-I3DM-01 (NCT06434727)
- Testing
- observational study
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Intuitive Surgical
Breast Cancer
Phase II Study in Patients With Operable Breast Cancer
The study will evaluate the safety and efficacy of the combination PLD, paclitaxel, and trastuzumab in patients with operable breast cancer. Patients will be treated with the combination for 18 weeks, followed by surgery.
- Trial name
- NCT00518583
- Testing
- Pegylated Liposomal Doxorubicin (Doxil)
- Where
- 9 sites in United States
- Volunteers
- 30 people
- Sponsor
- Aptium Oncology Research Network
Cardiac Surgery, Congenital Heart Disease
Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery.
- Conditions
- Cardiac Surgery, Congenital Heart Disease, Cardiopulmonary Bypass, Fibrinogenemia
- Trial name
- NCT05525195
- Testing
- Congenital cardiac surgery
- Where
- Belgium
- Volunteers
- 932 people
- Sponsor
- Brugmann University Hospital
Pain, Postoperative
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
The primary objective of this study is to assess the effect of preoperative administration of N1539 on opioid consumption in subjects undergoing open unilateral total knee arthroplasty compared to placebo.
- Trial name
- NCT03434275
- Testing
- N1539
- Where
- 6 sites in United States
- Volunteers
- 194 people
- Sponsor
- Baudax Bio
Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma
Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer
This randomized phase III trial is comparing the effectiveness of three adjuvant combination chemotherapy regimens in treating patients who are receiving radiation therapy and fluorouracil either before or after surgery for stage…
- Conditions
- Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma, Recurrent Rectal Carcinoma, Stage IIA Rectal Cancer AJCC v7
- Trial name
- NCT00068692
- Testing
- Radiotherapy, Fluorouracil, Leucovorin Calcium
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Cancer Institute (NCI)