Clinical trials: PreDiabetes, completed
Insulin Resistance, Type 2 Diabetes Mellitus
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
The purpose of this study is to examine the effects of treating insulin resistance on memory and attention, brain glucose utilization, and proteins in spinal fluid.
- Trial name
- NCT00212290
- Testing
- pioglitazone, nateglinide
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
PreDiabetes
β-hydroxybutyrate, Glucose Metabolism and Prediabetes
The study aims to investigate changes in blood glucose metabolism after administration of a ketone ester drink.
- Trial name
- CETUS (NCT03889210)
- Testing
- HVMN Ketone
- Where
- New Zealand
- Volunteers
- 18 people
- Sponsor
- University of Auckland, New Zealand
Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease
Healthy Liver - Healthy Brain
People with liver disease report difficulties with attention and problem-solving skills. Diet plays an important role in the development of liver disease and/or pre-diabetes.
- Conditions
- Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease, NAFLD, Pre-diabetes
- Trial name
- NCT05216796
- Testing
- Diet Intervention
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Smoking Cessation
Exenatide Once Weekly for Smoking Cessation
The purpose of this study is to identify a potential new treatment for smoking cessation.
- Trial name
- NCT02975297
- Testing
- Exenatide, NRT, Counseling
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus, Type 2, Pre-diabetes
Models of Nutrition From Continuous Glucose Monitors
With this study, researchers want to conduct ambulatory studies in which people (healthy, with T2D, or at-risk of T2D) will consume a variety of pre-set and conventional meals in free-living conditions while wearing one or more…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Diet Habit, Diet, Healthy
- Trial name
- NCT04991142
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Type 2 Diabetes, Obesity
Energy Flux and Fat Oxidation Using Low and High Glycaemic Index Foods
Purpose: This study is carried out to determine the effect of GI on 24 hour blood glucose profiles and energy regulation in Asians when fed a normal diet modulated with sweeteners.
- Conditions
- Type 2 Diabetes, Obesity, PreDiabetes
- Trial name
- NCT03031886
- Testing
- low glycaemic index intervention, high glycaemic index intervention
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Healthy, Obese
Circadian Rhythmicity in Cold-induced Thermogenesis
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.
- Conditions
- Healthy, Obese, Glucose Intolerance
- Trial name
- COLDR (NCT04406922)
- Testing
- Personalized cooling protocol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
PreDiabetes
Achilles Tendon and Balance in Prediabetes
The aim was to evaluate the Achilles tendon size and static and dynamic balance, as well as the role of Achilles tendon on balance in prediabetes.
- Trial name
- NCT06519396
- Testing
- ultrasonography evaluation, tetrax device evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Metabolic Syndrome
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome
The investigators previous research has suggested that lipid (fatty) composition in the muscle cells of mice plays a key role in their insulin sensitivity.
- Trial name
- COMP-SR (NCT02122666)
- Testing
- muscle biopsy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment, Alzheimer's Disease
BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM)
Mild Cognitive Impairment (MCI) represents a group of persons who are at risk of incident dementia in the near-term. Persons with MCI who have deficits in short-term recall (amnestic MCI) are at significant risk of incident…
- Trial name
- BDPP (NCT02502253)
- Testing
- grape seed polyphenolic extract, resveratrol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Postprandial Hyperglycemia
Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
- Trial name
- NCT02654301
- Testing
- Test 1, Test 2, Test 3
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Healthy
Efficacy of Different Doses of Amino Acids in 5AA+CrPic Water on Glucose Homeostasis in a Healthy Population.
It has previously been shown that a carbonated water including a defined amount of amino acids and chromium can decrease the postprandial glucose response.
- Trial name
- NCT03411395
- Testing
- 5AA+CrPic Water
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Pre Diabetes, Insulin Resistance
Precision Diets for Diabetes Prevention
With this study the investigators want to understand the physiological differences for people developing pre-diabetes and diabetes.
- Conditions
- Pre Diabetes, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- NCT03919877
- Testing
- Dietary, Oral Food Challege
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
PreDiabetes, Obesity
Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs
Individuals with prediabetes are at increased risk for developing diabetes. Higher hemoglobin A1c's (6.1-6.4%) are associated with a high risk of developing diabetes.
- Trial name
- NCT03200535
- Testing
- EHR gaps, Bulk outreach, Dietician call
- Where
- United States
- Volunteers
- 6,588 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2, Prediabetic State
Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients
The goal of this study is to explore the effects of FeatForward on physical activity and cardio-metabolic risk factors. The study will be implemented as a 2-arm randomized controlled trial (RCT) comparing the effects of…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Hypertension, Prehypertension
- Trial name
- NCT02551640
- Testing
- FeatForward App (on study smartphone)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
PreDiabetes, Obesity, Childhood
Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance
The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of…
- Trial name
- NCT05055219
- Where
- United States
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gestational Diabetes Mellitus, Pre-diabetes
Encourage Healthy Families
This study is a randomized intervention that will test two different approaches reflecting diverse levels of both intensity and cost, to achieving risk reduction of T2D.
- Trial name
- Encourage (NCT01823367)
- Testing
- Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes, Obesity
A Culturally Tailored Lifestyle Intervention to Prevent Diabetes in South Asians
The South Asian Community, people with origins in India, Pakistan, Bangladesh, Maldives, Nepal, Sri Lanka, or Bhutan, are more likely to get diabetes, get diabetes at younger ages, and do worse health-wise once they have diabetes…
- Trial name
- SHAPE (NCT01084928)
- Testing
- Lifestyle Intervention Classes
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University