Clinical trials: PreDiabetes, completed
Diabetes Mellitus, Pre Diabetes
Development and Validation of DM and Pre-DM Risk Prediction Model
Many DM and pre-DM remain undiagnosed. The aim is to develop and validate a risk prediction function to detect DM and pre-DM in Chinese adults aged 18-84 in primary care (PC). The objectives are to: 1.
- Trial name
- NCT04881383
- Testing
- OGTT and HbA1c
- Where
- Hong Kong
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Glucose Intolerance, Microbial Colonization
Effects of Tagatose on Glycemic Response and Gastrointestinal Microbiota in Healthy Adults
The primary objective of this clinical-trial is to determine, in subjects with impaired fasting glucose (IFG) and/or insulin resistance (IR), if tagatose meets the definition of a prebiotic, namely that consuming tagatose for 4…
- Trial name
- NCT06920641
- Testing
- Tagatose
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Prediabetes
We Can Prevent Diabetes: A Behavioral Intervention to Reduce Diabetes Risk in African Americans
Pre-diabetes, characterized by glucose levels that are above normal but below the diagnostic criteria for diabetes, is an increasingly common condition, particularly among African Americans.
- Trial name
- NCT01227473
- Testing
- Mindfulness-based diabetes prevention education group, Conventional diabetes prevention education group
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of North Carolina, Chapel Hill
Pre Diabetes
Personalized Nutrition for Pre-Diabetes
The Personalized Nutrition Project for Prediabetes (PNP3) study will investigate whether personalized diet intervention will improve postprandial blood glucose levels and other metabolic health factors in individuals with…
- Trial name
- NCT03222791
- Testing
- Algorithm-based diet, Mediterranean-style low-fat diet
- Where
- Israel
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Coronary Heart Disease, Acute Coronary Syndrome
Acarbose Cardiovascular Evaluation Trial
The purpose of this study is to determine whether acarbose therapy can reduce cardiovascular-related morbidity and mortality in patients with impaired glucose tolerance (IGT) who have established coronary heart disease (CHD) or…
- Conditions
- Coronary Heart Disease, Acute Coronary Syndrome, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- ACE (NCT00829660)
- Testing
- Acarbose
- Where
- 177 sites in China, Hong Kong
- Volunteers
- 6,526 people
- Sponsor
- University of Oxford
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2…
- Trial name
- SURMOUNT-5 (NCT05822830)
- Testing
- Tirzepatide, Semaglutide
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Pre-diabetes
Vitamin D in Minorities With Prediabetes
Vitamin D supplementation in minority subjects with both pre-diabetes and low vitamin D levels will delay the development of diabetes.
- Trial name
- NCT00876928
- Testing
- vitamin D
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Charles Drew University of Medicine and Science
Diabetes Mellitus, Pre-diabetes
Improving T2DM Detection Using Spot cHbA1c Test
Objectives: To evaluate the effectiveness of active opportunistic screening using point-of-care capillary Hemoglobin-A1c (POC-cHbA1c) testing, compared to venous HbA1c (vHbA1c) testing, in improving detection of type 2 diabetes…
- Trial name
- DM-REACH (NCT06382363)
- Testing
- POC-cHbA1c testing
- Where
- 8 sites in Hong Kong
- Volunteers
- 852 people
- Sponsor
- The University of Hong Kong
Prediabetic State
Pilot Stair Climbing Study
This pilot study seeks to demonstrate feasibility to conduct data collection and illustrate potential for effect of fractionalized bouts of stair climbing on glucose control in adults at risk for type 2 diabetes.
- Trial name
- NCT02827383
- Testing
- Stair Climbing Frequency
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Jennifer Gay
Type 2 Diabetes, Obesity, Prediabetes
The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter
The study is carried out to find out the inclusion of high and low glycaemic index foods to daily meals and how they impact 24 hour blood glucose fluctuations and energy regulation.
- Trial name
- NCT02631083
- Testing
- Breakfast, lunch, snack and dinner
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Insulin Resistance, Dementia
Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes
The purpose of this study is to evaluate the effects of liraglutide on the memory and attention of people with insulin resistance.
- Trial name
- LGT (NCT02140983)
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Stanford University
Breast Cancer, PreDiabetes
Diabetes Care for Breast Cancer Patients
The goal of this study is to find a new way to make diabetes care better for patients with breast cancer and diabetes who are currently receiving cancer treatment.
- Conditions
- Breast Cancer, PreDiabetes, Type 2 Diabetes
- Trial name
- NCT05565534
- Testing
- Nurse-practitioner led intervention
- Where
- 3 sites in United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Prediabetes
Prospective Follow-up of a Cohort of Pre-diabetics in the North of France (DiabeNord)
The purpose of this study is to identify in prediabetic subjects, physiopathological changes involved in the evolution to type 2 diabetes mellitus and to identify new biomarkers of type 2 diabetes risk in this population.
- Trial name
- DiabeNord (NCT01432509)
- Testing
- Prediabetes screening and prospective follow-up over 5 years
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Nantes University Hospital
Type 2 Diabetes
Lifestyle Control of Postprandial Hyperglycemia
Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes…
- Trial name
- NCT02683135
- Testing
- High-carbohydrate diet, Low-carbohydrate diet, Low-carbohydrate diet with post-meal walking
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of British Columbia
Obesity, Diabetes
Studying the Effect of Capsinoids on Brown Fat Using Infrared Thermal Imaging.
The primary hypothesis of this study is that consumption of capsinoids increases brown adipose tissue activity, detectable by infrared thermal imaging.
- Conditions
- Obesity, Diabetes, Impaired Glucose Tolerance
- Trial name
- NCT01961674
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Prediabetic State
Physical Activity and Obesity
The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by…
- Conditions
- Obesity, Prediabetic State, Sedentary Lifestyle
- Trial name
- NCT02060240
- Testing
- High Activity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Healthy, Pre-diabetic
The Effect of Acute Lysine Administration on α-aminoadipic Acid
This study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.
- Trial name
- NCT02756117
- Testing
- L-Lysine, Normal (0.9%) Saline
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Type 2, PreDiabetes
Exercise and Time of Day in Type 2 Diabetes
The overall purpose of the study is to test the effect exercise time of day in adults with type 2 diabetes or prediabetes. The overarching hypothesis is that afternoon exercise in the afternoon may promote better changes in…
- Trial name
- NCT05108987
- Testing
- Morning Exercise, Afternoon Exercise
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Diabetes Mellitus, Non-Insulin-Dependent
The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)
The primary objectives of the ORIGIN study were: To determine whether insulin glargine-mediated normoglycemia can reduce cardiovascular morbidity and/or mortality in people at high risk for vascular disease with either Impaired…
- Trial name
- ORIGIN (NCT00069784)
- Testing
- insulin glargine (HOE901), omega-3 polyunsaturated fatty acids (PUFA), reusable pen device for insulin injection
- Where
- 40 sites in United States, Argentina and 38 more
- Volunteers
- 12,537 people
- Sponsor
- Sanofi