Clinical trials: PreDiabetes, completed
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Glucose Intolerance, Overweight and Obesity
GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response
This project investigates the anti-obesity mechanisms of glucagon-like peptide-1 (GLP-1) analogs, which are used in the treatment of human obesity and diabetes mellitus.
- Conditions
- Glucose Intolerance, Overweight and Obesity, Drug Effect, Adiposity
- Trial name
- NCT04387201
- Testing
- Cyanocobalamin, Dulaglutide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Risk Factor, Prediabetes
Active You: Feasibility of a Unique Physical Activity Program to Prevent Diabetes and Heart Disease
Individuals who are overweight/obese are more vulnerable to type 2 diabetes (T2D). Current evidence suggests that PA, even without dietary prescription, can be efficacious in preventing T2D.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04621045
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pre Diabetes, Obesity
Effects of Different Types of Carbohydrates in Snacks and Beverages on Glycemia, Insulinemia and Appetite.
The aim of the study is to describe the glycemic, insulinemic and appetitive responses to liquid and solid foods where either soluble fiber or maltodextrin are used as the carbohydrate substrate.
- Trial name
- NCT03279107
- Testing
- Soluble corn fiber, maltodextrin
- Where
- Singapore
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- JeyaKumar Henry
Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance
Diabetes Prevention Program
The Diabetes Prevention Program is a nationwide clinical study to answer the question: Can Type 2 diabetes (also called noninsulin-dependent or adult-onset diabetes) be prevented or delayed? The study has recruited volunteers…
- Trial name
- NCT00004992
- Testing
- Intensive lifestyle, Metformin
- Where
- United States
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pre-diabetes
Impact of High Fiber and Vegetal Protein Diet on Gut Health and Immunity Biomarkers in Prediabetic Patients
The research area that focuses on the links between nutrition and health, nutrition and the immune system as well as nutrition-related public health interventions, which often falls into the gap between the agricultural and…
- Trial name
- PreVegDiet (NCT06147323)
- Testing
- Normal Healthy Diet, Seaweed Group
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Pre Diabetes, Postprandial Hyperglycemia
Evaluating the Acute Glycemic Response to Different Strategies of Breaking Up Sedentary Time
This study aims to determine the most effective strategy of reducing sedentary behavior to improve health. Specifically, we aim to answer the following questions: (a) To determine if there is a significant difference in acute…
- Trial name
- NCT04144920
- Testing
- CS: Continuous sitting, HFLD: HIgh frequency, low duration standing breaks, LFHD: Low frequency, high duration standing breaks
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Arizona State University
Prediabetes
Interdisciplinary and Family Intervention to Prevent Type 2 Diabetes
The purpose of the study is to evaluate the effect of a family and interdisciplinary approach on individual and family insulin resistance and insulin secretion in patients with prediabetes.
- Trial name
- CARE-in-DEEP (NCT02635646)
- Testing
- Family and interdisciplinary approach, individual approach
- Where
- Mexico
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Impaired Glucose Tolerance, Overweight
Effective Endurance Training in Metabolic Syndrome
To see how fast and how much physical training can reduce risk factors related to metabolic syndrome
- Conditions
- Impaired Glucose Tolerance, Overweight, Hypertension, Dyslipidemia
- Trial name
- NCT00218998
- Testing
- exercise training
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Glucose Intolerance, Obesity
The Snack Study: The Feasibility of Changing Night-time Food Choices to Improve Glucose Tolerance in Pregnancy
Obesity during pregnancy increases the risk for high glucose and diabetes in the mother, and for obesity and comorbid metabolic disease in the offspring.
- Trial name
- NCT02634593
- Testing
- Low glycemic load snacks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Prediabetes
Effects of Aerobic Exercise in Patients With Pre-diabetes
It is well known that diabetes and excessive or high blood sugars causes blood vessel and blood cell damage. It is also possible, then, that people with pre-diabetes may also start to have blood vessel and blood cell damage as…
- Trial name
- NCT01860599
- Testing
- Exercise, Without exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baystate Medical Center
Obesity, Metabolic Syndrome
Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults
The purpose of the study was to determine the effects of growth hormone and an insulin sensitizer drug in pre-diabetic adults with excessive amounts of abdominal fat.
- Conditions
- Obesity, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT00352287
- Testing
- Recombinant human growth hormone; pioglitazone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pre-diabetes
Supplementation of YMETA, on Gut Health, Immunity and Metabolism in Pre-diabetic Adult Population
Type 2 diabetes mellitus (T2DM) is a major non-communicable disease and one of the world's fastest growing health problems. According to a 2019 report, about 463 million adults worldwide currently have diabetes and future…
- Trial name
- YMETA (NCT05400525)
- Testing
- YMETA
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Roehampton
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Effects of Colesevelam HCl On Bile Acid Kinetics
This project will compare the amount of bile acids and their kinetics in overweight and obese people with normal glucose metabolism, impaired glucose tolerance and frank type 2 diabetes.
- Trial name
- NCT00476710
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- KineMed
Endocrine Disease, Diabetes
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
Background: Metabolic syndrome is a name given to a group of factors that tend to occur together. These risk factors include central obesity (extra weight around the middle of the body) and high blood pressure and blood sugar…
- Trial name
- NCT01419535
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity
Identification of Muscle-specific Biomarkers of Fatty Acid Beta-oxidation
Elevated fat levels within skeletal muscle cells (intramyocellular lipids) are highly correlated with muscle and whole-body insulin resistance, and more prevalent in obesity.
- Trial name
- FL-68 (NCT01494025)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
PreDiabetes, Diabetes
New Diabetes Mellitus and Pre-Diabetes With First-time Diagnosed Coronary Artery Disease
A prospective analytic study to evaluate the incidence, clinical and laboratory characteristics, extent of coronary artery disease and short-term outcome of newly diagnosed diabetes and pre-diabetes in patients with first-time…
- Conditions
- PreDiabetes, Diabetes, Coronary Artery Disease
- Trial name
- DMCAD (NCT05208424)
- Testing
- Coronary angiography
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- Saud Al Babtain Cardiac Center
Pre-diabetes
Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
Early Phase Pre-Clinical and Initial Clinical Research on (+)- Epicatechin.
- Trial name
- Epicatechin (NCT02330276)
- Testing
- (+)-Epicatechin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Diabetes Mellitus, Hyperglycemia
Durban Diabetes Study:A Study of the Epidemiology of Diabetes Mellitus in Urban South Africans of African Descent (DDS)
Type 2 diabetes (T2D) is an emerging epidemic in sub-Saharan Africa, with an estimated prevalence of 6%. With around seven million cases of T2D in 2000, it is anticipated that over 18 million Africans will have the disease by…
- Conditions
- Diabetes Mellitus, Hyperglycemia, Hereditary Diseases, Glucose Intolerance
- Trial name
- DDS (NCT02416440)
- Testing
- blood sample
- Where
- South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu