Clinical trials: PreDiabetes, completed
Type 2 Diabetes, PreDiabetes
Butyrate-enriched Triglyceride and Diabetes Prevention
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT06384313
- Testing
- butyrate/hexanoate-enriched triglycerides
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
PreDiabetes, Obesity
Promotora-Led Intervention for Metabolic and Mental Health
Evidence-based programs to prevent diabetes among high-risk individuals are less effective among those who also have mental health needs.
- Conditions
- PreDiabetes, Obesity, Metabolic Disease, Body Weight Changes
- Trial name
- PRIME2 (NCT03372018)
- Testing
- Promotora-led Intervention (PLI), Usual care (UC)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
PreDiabetes
Insulin Modelling Based on Plasma Glucose Measures Via a Minimally-Invasive Glucose Sensor
The study aims to evaluate insulin as a potential biomarker for prediabetes in Singapore Chinese subjects.
- Trial name
- NCT06119035
- Testing
- Single dose of 75 grams glucose in 200ml water
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Pre-diabetes
Resveratrol and First-degree Relatives of Type 2 Diabetic Patients
The main objective of the study is to investigate if resveratrol supplementation can improve overall and muscle-specific insulin sensitivity in first-degree relatives of type 2 diabetic patients.
- Trial name
- NCT02129595
- Testing
- resveratrol
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Congestive Heart Failure
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
This study will evaluate the safety and effectiveness of the drug rosiglitazone for improving heart function in patients with heart failure and glucose intolerance or type II (adult-onset) diabetes, or both.
- Trial name
- NCT00064727
- Testing
- Avandia (Rosiglitazone), Avanclia (Rosiqlitazone)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pre Diabetes
Role of Glycaemic Index and High Protein Meal in Response of Blood Biomarkers for Pre-diabetes
This study aims to demonstrate the effectiveness of increased protein ingestion, particularly when coupled with a low glycaemic index (GI) to reduce biomarkers related to high risk of diabetes.
- Trial name
- NCT03309254
- Testing
- High Glycemic Index, Low Glycemic Index
- Where
- Singapore
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Prediabetes, Exercise
Optimization of Exercise Protocol for Prediabetic Population in Postprandial State
The core purpose of the project is to find out optimal exercise protocol for control of hyperglycemia and insulin resistance in prediabetic.
- Conditions
- Prediabetes, Exercise, Blood Glucose Profile, Lipid Profile
- Trial name
- NCT06656377
- Testing
- exercise intervention
- Where
- Pakistan
- Volunteers
- 25 people
- Sponsor
- Khyber Medical University Peshawar
PreDiabetes
Impact of Alpha-Lipoic Acid Ingestion on Glucose Tolerance in Subjects With Pre-Diabetes
Obesity, with a prevalence of over 35% in American adults, is considered the most critical threat to the health and well-being of Americans.
- Trial name
- NCT03612037
- Testing
- alpha lipoic acid, Cellulose
- Volunteers
- 12 people
- Sponsor
- State University of New York at Buffalo
Type 2 Diabetes, Prediabetes
Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism
It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose and insulin response.
- Trial name
- NCT02235194
- Testing
- Amino Acid and chromium-picolinate containing drink
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Gestational Diabetes, Glucose Intolerance
Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes
The study is being done in order to gain information on the most suitable types of birth control in women who recently had gestational diabetes, or diabetes diagnosed during pregnancy.
- Conditions
- Gestational Diabetes, Glucose Intolerance, Type 2 Diabetes, Intrauterine Contraception
- Trial name
- NCT01022645
- Testing
- Mirena (Levonorgestrel IUD), Paragard (Copper IUD ) or Tubal Ligation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwestern University
Insulin Resistance, Prediabetic State
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.
- Trial name
- NCT01956929
- Testing
- Metformin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes, Normoglycemic
Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects
Aim of the study is to investigate the postprandial response on blood glucose, insulin, C-peptide, incretin response and gastric emptying after intake of collagen hydrolysate compared to placebo in normoglycemic and in…
- Trial name
- NCT06789263
- Testing
- Collagen hydrolyzed peptides
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Gestational Diabetes Mellitus
Prevention of Diabetes Mellitus Type 2 in Women Post Gestational Diabetes Mellitus Diagnosis
Diabetes Mellitus (DM) is a chronic metabolic disorder with increasing incidence and long term complications. Its incidence differs in various ethnic populations.Gestational DM (GDM) is diagnosed when impaired glucose tolerance…
- Trial name
- GDM (NCT01480895)
- Testing
- Lifestyle instruction for Jews and Bedouin GDM women.
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Gestational Diabetes Mellitus
MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study
MAIN STUDY: Low glycaemic index (GI) diets are recommended by the Canadian Diabetes Association for treating type 1 and 2 diabetes mellitus (DM), but the role of GI in the management of gestational diabetes(GDM)is not yet clear.
- Trial name
- GIinGDM (NCT01589757)
- Testing
- Standard Care, Low GI diet
- Where
- 4 sites in Canada
- Volunteers
- 99 people
- Sponsor
- University of Toronto
Overweight and Obesity, PreDiabetes
Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study
The overall goal is to determine the real-world feasibility and utility of body fat imaging using rapid MRI to enhance risk perception, induce behavioral change, and improve clinical outcomes in overweight and obese individuals.
- Conditions
- Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
- Trial name
- BODY-REAL (NCT04763772)
- Testing
- Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University Hospitals Cleveland Medical Center
PreDiabetes
Preventing Diabetes With Digital Health and Coaching
The goal of this randomized controlled trial is to determine the efficacy of a digital diabetes prevention program for improving weight, glucose control, and secondary risk factors among people with prediabetes compared to an…
- Trial name
- PREDICTS (NCT03312764)
- Testing
- Online diabetes prevention program, Standard Care
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Omada Health, Inc.
Spinal Cord Injuries, Insulin Resistance
Once Weekly GLP-1 in Persons With Spinal Cord Injury
Chronic spinal cord injury (SCI) results in adverse soft tissue body composition changes and an extremely sedentary lifestyle. These abrupt changes often lead to a high prevalence of cardiometabolic diseases, such as impaired…
- Conditions
- Spinal Cord Injuries, Insulin Resistance, Pre Diabetes, Obesity
- Trial name
- NCT03292315
- Testing
- Semaglutide 1MG Injection [Ozempic], No Intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Pre-diabetes
AI-Assisted Blood Glucose Management Study
AI-driven health management tools can leverage continuous glucose monitoring (CGM), physical activity, and dietary data to provide real-time, individualized feedback, improving self-management and adherence.
- Trial name
- NCT07160985
- Testing
- AI-based Lifestyle Management, Lifestyle Management
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Li Huating
Metabolic Syndrome X, Overweight
Chloroquine to Treat People With Metabolic Syndrome Aim2 (ARCH-MS)
Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Overweight, Hypertension, Dyslipidemias
- Trial name
- ARCH-MS (NCT00455325)
- Testing
- Active Comparator: Second Intervention (3 weeks), Active Comparator: Third Intervention (3 weeks), Active Comparator: Fourth Intervention (3 weeks)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Washington University School of Medicine