Clinical trials: PreDiabetes, completed
PreDiabetes
Patient-centered Goal Setting in the National Diabetes Prevention Program
This is a cluster-randomized controlled trial of NDPP-Flex versus the standard NDPP to evaluate effects on glycemia, heterogeneity of treatment effects, and mechanisms of change.
- Trial name
- NDPP-Flex (NCT05559515)
- Testing
- NDPP-Flex, NDPP
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Denver Health and Hospital Authority
Glucose Intolerance
A Low Glycemic Index Diet for Prevention of Glucose Intolerance During Bed Rest
Recovery from surgery, injury or illness might require periods of bed rest in-hospital or at home. Bed rest may be needed for recovery but also has negative consequences.
- Trial name
- NCT03595943
- Testing
- Low glycemic index, pulse-based diet, Moderate glycemic index hospital diet
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Overweight, Pre-hypertension
Short Term Intermittent Fasting and Mediterranean Diet
The purpose of this research study is to evaluate the effects of intermittent fasting in subjects that are eating a Mediterranean diet or a Western diet.
- Conditions
- Overweight, Pre-hypertension, Hypertension, Hypercholesterolemia
- Trial name
- NCT02148458
- Testing
- Mediterranean diet, Control group
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 2, PreDiabetes
Contrasting Ketogenic and Mediterranean Diets in Individuals With Type 2 Diabetes and Prediabetes: The Keto-Med Trial
The objective of this study is to compare two metabolically distinct diets, WFKD vs Med-Plus, in order to examine the potential benefits, and unintended consequences, of going beyond a focus on maximally avoiding added sugars and…
- Trial name
- NCT03810378
- Testing
- Mediterranean Diet (Med-Plus), Well-Formulated Ketogenic Diet (WFKD)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cystic Fibrosis
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
This study will investigate the link between glucose abnormalities and elements critical to muscle function including mass, composition and energy metabolism.
- Trial name
- NCT02776098
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Obesity
Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes
This study looks at how well a new medicine, called semaglutide, works at helping people with obesity and prediabetes. This study will look at how much weight participants lose, and if participants can go from having blood sugar…
- Trial name
- STEP 10 (NCT05040971)
- Testing
- Semaglutide 2.4 mg
- Where
- 43 sites in Canada, Denmark and 3 more
- Volunteers
- 207 people
- Sponsor
- Novo Nordisk A/S
Prediabetes
Prebiotics, Gut Microbiota, and Cardiometabolic Health
Forty-eight prediabetic men and women (50-75 years of age) will participate in a 6-week feeding study in which they will randomized to receive either 10 g/day of inulin or placebo.
- Trial name
- NCT02346838
- Testing
- Inulin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Virginia Polytechnic Institute and State University
Pre-diabetes
Diabetes Prevention Program Pilot
This initiative, which is a partnership between State College area Penn State Health ambulatory care clinics located off campus in the State College area, has two primary goals: 1) improve the health and quality of life of Penn…
- Trial name
- NCT04651816
- Testing
- Financial Incentives, Motivational Message, DPP Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Neoplasms, Adipose Tissue
Sitagliptin and Brown Adipose Tissue
The obesity epidemic has resulted in an exponential increase in obesity-related disorders including type 2 diabetes, dyslipidemia and cardiovascular disease.
- Trial name
- Sita01 (NCT02294084)
- Testing
- Sitagliptin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Impaired Glucose Tolerance
Breaks in Sedentary Time and Glucose Regulation in Women
The number of people diagnosed with Type 2 diabetes (T2DM) is increasing rapidly and about 2.9 million people in the UK currently have diabetes.
- Trial name
- ACUTE (NCT02135172)
- Testing
- Sitting, Standing, Walking
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Leicester
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Glucose Intolerance
Effects of a Dietary Supplement Containing Salacia Extract, Citrus Bioflavonoids, and Trivalent Chromium on Markers of Glucose Control
This study was a double-blind, randomized, placebo-controlled, clinical trial with two parallel groups. Participants reported to a single investigational center in Ohio (i.e., The Center for Applied Health Sciences) during the 12…
- Trial name
- NCT05887050
- Testing
- Active
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The Center for Applied Health Sciences, LLC
Diabetes Mellitus, Type 2
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and…
- Trial name
- NCT00520962
- Where
- Italy
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Normal, Impaired Fasting Glucose
A Crossover Trial of Chitosan Oligosaccharide on Post Prandial Glucose Control in Subjects With Normal, IFG and IGT
It is well known that Chitosan oligosaccharide is low molecular weight and water soluble and chitosan oligosaccharide has been shown to reduce blood cholesterol and blood pressure, increase immunity, and enhance antitumor…
- Conditions
- Normal, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT03650023
- Testing
- Chitosan Oligosaccharide (GO2KA1), White egg
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Impaired Glucose Tolerance, Cardiovascular Disease
The DREAM (Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication) Trial
The purpose of this study is to determine if ramipril and/or rosiglitazone prevent the onset of type 2 diabetes.
- Conditions
- Impaired Glucose Tolerance, Cardiovascular Disease, Glucose Metabolism Disorders
- Trial name
- NCT00095654
- Testing
- Ramipril, Rosiglitazone
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Gerstein, Hertzel, MD
Pre Diabetes, Impaired Glucose Tolerance
Efficacy and Safety of 12-weeks Supplementation of Eubacterium Hallii on Insulin Sensitivity and Glycaemic Control
This 12 week placebo-controlled study evaluates the efficacy and safety of E. hallii supplementation.
- Conditions
- Pre Diabetes, Impaired Glucose Tolerance, Insulin Sensitivity, Insulin Resistance
- Trial name
- NCT04529473
- Testing
- Eubacterium hallii
- Where
- 3 sites in United States, Ireland and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Obesity, Type 2 Diabetes
GOAL Life-Style Change Intervention to Prevent Type 2 Diabetes
Life-style change achieved in controlled experimental condition has been shown to prevent type 2 diabetes. The purpose of this study is to evaluate to what extent the life-style change can be achieved in a routine health care…
- Trial name
- NCT00398060
- Testing
- Cognitive-behavioral life-style counseling
- Where
- Finland
- Volunteers
- 389 people
- Sponsor
- Finnish Institute for Health and Welfare
Type 2 Diabetes
Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program
This study was conducted to test the possibility of preventing or delaying the development of type 2 diabetes in individuals with impaired glucose tolerance and elevated fasting plasma glucose concentrations by internet-based…
- Trial name
- NCT01085682
- Testing
- Lifestyle counseling, Standard care
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea