Clinical trials: PreDiabetes, completed
Pre-diabetes, Obesity
Effect of Diet and Physical Activity on Incidence of Type 2 Diabetes
Type-2 diabetes is one of the fastest growing chronic diseases worldwide. This trend is mainly driven by a global increase in the prevalence of obesity.
- Trial name
- PREVIEW (NCT01777893)
- Testing
- High protein/ high intensity physical activity (HP-HI), High protein / moderate intensity physical activity (HP-MI), Moderate protein/ high intensity physical activity (MP-HI)
- Where
- 9 sites in Australia, Bulgaria and 6 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Anne Birgitte Raben
Prediabetes
The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers
Hypothesis 1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2.
- Trial name
- Sleep GLP-1 (NCT02229487)
- Testing
- Oral glucose tolerance
- Where
- Thailand
- Volunteers
- 51 people
- Sponsor
- Ramathibodi Hospital
Diet, PreDiabetes
Dietary Pattern and Metabolic Health Study
This is a single-blind, randomized trial. Based on inclusion and exclusion criteria, 253 eligible volunteers, who were 25-60 years old, with overweight/obese and prediabetes are assigned to one of three dietary patterns: healthy…
- Conditions
- Diet, PreDiabetes, Weight Loss
- Trial name
- NCT03856762
- Testing
- traditional Jiangnan diet, Mediterranean diet, Current Shanghai diet
- Where
- China
- Volunteers
- 253 people
- Sponsor
- Chinese Academy of Sciences
Glucose Intolerance
Acetylcarnitine and Metabolic Flexibility
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02072759
- Testing
- Carnitine supplement
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
PreDiabetes
Emotional Awareness and Expression Therapy for Prediabetes
This feasibility study seeks to develop and pilot test Emotional Awareness and Expression Therapy as a possible treatment for people with prediabetes.
- Trial name
- NCT05344196
- Testing
- Modified EAET for prediabetes
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Glucose Intolerance
The Effects of Light on Glucose Metabolism
This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.
- Conditions
- Diabetes Mellitus, Type 2, Glucose Intolerance, Prediabetic State
- Trial name
- NCT03829982
- Testing
- Exposure to bright light during the day, Exposure to dim light during the day
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Obesity, Overweight
Smart Technology for Weight Loss and Metabolic Health
The study will evaluate whether a technology-based lifestyle intervention program using primarily a smartphone platform is an acceptable and effective way for treating obesity.
- Conditions
- Obesity, Overweight, Prediabetes, Weight Loss
- Trial name
- NCT02742662
- Testing
- Wearable technology, smartscale, Smartphone applications, Standard Weight Management Visits
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Temple University
PreDiabetes, Prediabetic State
Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes
The goal of this randomized pilot clinical trial is to describe the feasibility of a couple-based lifestyle intervention and the study protocol in preparation for a future definitive randomized clinical trial.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05695170
- Testing
- PreventT2 (Individual intervention), PreventT2 Together (Couple-based intervention)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
Coronary Artery Disease, Glucose Intolerance
Exercise Training, Insulin Resistance and Coronary Artery Disease
The purpose of this study was to determine the effects of exercise training on insulin resistance in subjects with coronary artery disease independent of changes in weight, diet, or the effect of an acute bout of exercise.
- Trial name
- NCT00412815
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Impaired Glucose Tolerance
Glycemic and Insulinemic Impact of Selected Canadian Beans
The objective of this study is to compare the glycemic and insulinemic response elicited by ½ cup servings of 6 beans to those elicited by ½ cup servings of mashed potato, macaroni, rice and corn.
- Trial name
- MED-beans (NCT02907190)
- Testing
- Bean Type, Starchy Foods
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Impaired Glucose Tolerance, Peripheral Polyneuropathy
Electrodiagnostic Parameters in Patients With Impaired Glucose Tolerance and Diabetes Mellitus
The purpose of this study is to evaluate the distal sensory nerves of the feet, namely, the dorsal sural, medial dorsal cutaneous and medial plantar nerves, in patients with impaired glucose tolerance and diabetes mellitus type 2…
- Conditions
- Impaired Glucose Tolerance, Peripheral Polyneuropathy, DM
- Trial name
- NCT01094418
- Testing
- Nerve conduction studies ( NCS) of the peripheral nerves
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Prediabetic State
Effect of Atorvastatin on Glycemic Control in Prediabetic Patients
The study was conducted to find out any possible effect of Atorvastatin on glycemic parameters in prediabetic patients.
- Trial name
- NCT02470455
- Testing
- Atorvastatin
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Shri Ramachandra Bhanj Medical College
Obesity
Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial
A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS), combined with a lifestyle modification program, compared to a sham control and a lifestyle modification…
- Trial name
- VeSTAL (NCT03640286)
- Testing
- VeSTAL
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Prediabetes
Prevention of Type 2 Diabetes Mellitus by Changes in Diet
investigators evaluated the efficacy of two types of diet with different macronutrients, on prevention or delaying the onset of type 2 diabetes in subjects with either impaired fasting glucose (IFG) or impaired glucose tolerance…
- Trial name
- NCT02250066
- Testing
- Diet
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ilam University of Medical Sciences
PreDiabetes
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
One in three American adults have prediabetes, and up to 70% of adults with prediabetes eventually develop type 2 diabetes. With the high cost of treating diabetes, cost-effective approaches are needed to reduce the incidence of…
- Trial name
- NCT03504683
- Testing
- Early TRE, Mid-day TRE, Control Schedule
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Heart Diseases, Diabetes Mellitus, Type 2
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
This single-arm trial of the Cardiovascular Risk Reduction Among People Experiencing Homelessness (CV-Homes) intervention alone (n=8) will test the perception and feasibility of anticipated study procedures.
- Conditions
- Heart Diseases, Diabetes Mellitus, Type 2, Pre-diabetes, Hypertension
- Trial name
- CV-Homes (NCT06025721)
- Testing
- Cardiovascular Risk Homeless Support
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Katherine Vickery
Pre-diabetes
Common Genetic Variation and Type 2 Diabetes
Type 2 diabetes is a common metabolic disorder arising from a complex interaction between genetic predisposition and the environment.
- Trial name
- NCT00707616
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes, Vitamin D Deficiency
Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a major public health problem .Prevalence of vitamin D deficiency is also high i.e. 78-96% in different groups of population in north India.
- Trial name
- NCT01436916
- Testing
- oral cholecalciferol + life style counselling
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh