Clinical trials: PreDiabetes, completed
Cystic Fibrosis Homozygous for Phe 508 Del CFTR, Glucose Intolerance or Newly Diagnosis Diabetes
Observational Study of Glucose Tolerance Abnormalities in Patient With Cystic Fibrosis Homozygous for Phe 508 Del CFTR Treated by Lumacaftor-Ivacaftor
Cystic Fibrosis related diabetes (CFRD), a major factor of morbid-mortality in CF, is characterized by a preclinical phase of glucose intolerance particularly long reaching up to 10 years.
- Trial name
- GLUCORRECTOR (NCT03512119)
- Testing
- Lumacaftor-Ivacaftor treatment
- Where
- 13 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
Pre-Diabetic, Overweight
Feasibility of an Interval Exercise and Nutrition Intervention to Reduce Cardiovascular Disease Risk Factors
Purpose : Test the feasibility (acceptability, adherence) of a home-based interval exercise training (IET) and nutrition program, as well as its preliminary effects on resting heart rate, blood pressure, fasting glucose, HDL…
- Conditions
- Pre-Diabetic, Overweight, Obesity
- Trial name
- IETnutrition (NCT02482922)
- Testing
- Exercise & Dietary Supplement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Weight Loss Trial, Cardiometabolic Syndrome
Peau o le Vasa: Analysis of the Efficacy and Feasibility of the PILI Lifestyle Program (PLP) + Social Determinants of Health (SDOH) Intervention and Adaptation of SDOH Measures Pilot Study
Native Hawaiians and Pacific Islanders (NHPIs) are defined as the descendants of the original peoples of Polynesia (e.g., Hawai'i, Sāmoa, and Tonga), Melanesia (e.g., Fiji), and Micronesia (e.g., Guam, Chuuk, and Marshall…
- Conditions
- Weight Loss Trial, Cardiometabolic Syndrome, Hypertension, Dyslipidemia
- Trial name
- NCT06471595
- Testing
- Partnership for Improving Lifestyle Intervention (PILI) Lifestyle Program + Social Determinants of Health (SDOH) Component
- Where
- 4 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Hawaii
Diabetes Mellitus, Prediabetic State
Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes
An increased risk of incident diabetes with statin therapy have been reported in several studies. However, it is not recommended to limit the use of statin for this reason since the absolute risk increase was small, and the…
- Trial name
- NCT02754739
- Testing
- Pravastatin, Nutritional education only
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
PreDiabetes
Preventing Diabetes
The purpose of this project is to improve the quality of weight management care for patients with pre-diabetes and overweight or obesity.
- Trial name
- PD (NCT05395377)
- Testing
- Registered Dietitian/Nutritionist, Diabetes Prevention Program, Weight Watchers, Reimagined
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Geisinger Clinic
PreDiabetes
Effects of Allium Hookeri on Blood Glucose
The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.
- Trial name
- NCT03330366
- Testing
- Allium hookeri extract
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Gestational Diabetes Mellitus
MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study
MAIN STUDY: Low glycaemic index (GI) diets are recommended by the Canadian Diabetes Association for treating type 1 and 2 diabetes mellitus (DM), but the role of GI in the management of gestational diabetes(GDM)is not yet clear.
- Trial name
- GIinGDM (NCT01589757)
- Testing
- Standard Care, Low GI diet
- Where
- 4 sites in Canada
- Volunteers
- 99 people
- Sponsor
- University of Toronto
Healthy, Pre Diabetes
Millet-based Muffins, Glycaemic Response, Insulinemic Response and Gastric Emptying
Millet is a functional grain that has attracted the attention of scientists for many years due to its significant benefits to human health.
- Trial name
- NCT04599738
- Testing
- Wheat muffin, Finger millet grain muffin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Pre Diabetes, Overweight and Obesity
TRE With Physical Activity for Weight Management
Approximately 24 million older adults have prediabetes. Obesity, age related decreases in lean mass and increases in fat mass, and sedentary lifestyle have been associated with functional and cognitive decline in older adults.
- Trial name
- NCT04978376
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Illinois Chicago
PreDiabetes, Diabetes Mellitus, Type 2
Improving Individual Glycemic Response With Exercise Intensity
Large interindividual variability exists in the glycemic response to exercise program, resulting in a subset of individuals known as exercise non-responders (NRs).
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Exercise, Physical Activity
- Trial name
- INTENSITY (NCT03787836)
- Testing
- Maintained Exercise, Increased Intensity
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of New Brunswick
Gestational Diabetes Mellitus
Prevention of Diabetes Mellitus Type 2 in Women Post Gestational Diabetes Mellitus Diagnosis
Diabetes Mellitus (DM) is a chronic metabolic disorder with increasing incidence and long term complications. Its incidence differs in various ethnic populations.Gestational DM (GDM) is diagnosed when impaired glucose tolerance…
- Trial name
- GDM (NCT01480895)
- Testing
- Lifestyle instruction for Jews and Bedouin GDM women.
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Obesity, Pre Diabetes
Inulin and Acetate Production and Human Substrate Metabolism
Based on our hypothesis that orally administered resistant starch and inulin/beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy…
- Trial name
- NCT03711383
- Testing
- Inulin and Resistant Starch, Inulin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes, Pre-diabetes
Immediate and Long-term Induction of Incretin Release by Artificial Sweeteners 2
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft drinks may play a role in the development of diabetes.
- Trial name
- ILIAS-2 (NCT02487537)
- Testing
- custom-made soft drink
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
PCOS
Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome
Metformin is the first-line therapy for PCOS with high metabolic risk, yet a large proportion of patients cannot tolerate it due to associated gastrointestinal adverse events.
- Trial name
- NCT03122041
- Testing
- Sitagliptin, Lifestyle intervention
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Pre-diabetes
Metformin and Sitagliptin in Women With Previous Gestational Diabetes
The goal of the present research is to compare the effects of treatment with metformin and sitagliptin, alone or in association, in women with previous gestational diabetes to evaluate the impact of the two drugs on beta-cell…
- Trial name
- NCT01336322
- Testing
- Metformin, Sitagliptin, Sitagliptin + Metformin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pisa
Obesity, Pre-diabetes
Evaluation of Lifestyle Interventions to Treat Elevated Cardiometabolic Risk in Primary Care
The purpose of the E-LITE Study is to evaluate the feasibility and potential effectiveness of two lifestyle interventions in a community based primary care setting.
- Conditions
- Obesity, Pre-diabetes, Metabolic Syndrome
- Trial name
- E-LITE (NCT00842426)
- Testing
- Self-management program (SM), Care management program (CM)
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Palo Alto Medical Foundation
Obesity, Prediabetes
Effect of Aerobic Exercise Program on Blood Glucose Level and Quality of Life in Pre-diabetic Overweight/Obese Adolescents
PURPOSE: The study aims to: Investigate the effect of the designed aerobic exercise program on the blood glucose level (fasting blood glucose and HbA1C) in overweight/ obese pre-diabetic adolescents.
- Trial name
- NCT06756425
- Testing
- aerobic exercise program, nutritional health awareness sessions
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pre-diabetes
ELFI Health (e-Health for Empowerment by Lifestyle, Food Advice and Interaction)
In the present study the investigators will examine whether people living with prediabetes benefit from an e-health lifestyle intervention of three months.
- Trial name
- ELFI (NCT06236334)
- Testing
- ELFI lifestyle intervention
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- TNO
Prediabetic State, Obesity
Presessions for the National Diabetes Prevention Program
The National Diabetes Prevention Program (NDPP) is a widely available, evidence-based intervention that promotes weight loss to prevent type 2 diabetes; however, participant attendance is problematic and leads to suboptimal…
- Conditions
- Prediabetic State, Obesity, Gestational Diabetes
- Trial name
- NCT04022499
- Testing
- Presessions, National Diabetes Prevention Program
- Where
- United States
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Diabetes Prevention in Women After GDM Who Are at High-risk
Dapagliflozin and Metformin,Alone and in Combination, in Overweight/Obese Prior GDM Women
Women with a history of gestational diabetes (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). Compared with the general population, these women are more likely to be overweight or obese.
- Trial name
- DAPA-GDM (NCT02338193)
- Testing
- DAPA/MET XR, DAPA, MET XR
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Woman's