Clinical trials: PreDiabetes, completed
Cardiovascular Disease
Prevention of Cardiac and Vascular Events in Patients With NGT/IGT.
Impaired glucose tolerance or mild glucose elevations in the non-diabetic range are associated with increased cardiovascular disease and recent studies suggested the need to detect these glucose abnormalities early in the…
- Trial name
- NCT00408577
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Glucose Intolerance, Obesity
Identification of Predictors of Success for Lifestyle Modifications in Overweight Pre-diabetic Subjects
The primary objective of the study is to identify baseline and early predictors of favorable and unfavorable response to lifestyle intervention.
- Trial name
- NCT00969007
- Testing
- Lifestyle modification counselling
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Marie-France Langlois
Prediabetes, Impaired Fasting Glucose
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
Prediabetes is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, involving a higher risk of progression type 2 diabetes mellitus (T2DM).
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT02700334
- Testing
- Dapagliflozin
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Prediabetes, Cardiovascular Disease
Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
Cardiovascular disease (CVD) is largely a lifestyle-related condition that is the #1 killer of adults in the United States. Our work is aimed at understanding how short-term increases in blood sugar, like those that accompany…
- Trial name
- NCT02364570
- Testing
- Glucose (100g), Glucose (75g), Whole Eggs
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Non-alcoholic Fatty Liver Disease (NAFLD)
Study of Magnetic Resonance Imaging (MRI) to Quantify Liver Fat in Diabetic and Pre-Diabetic Patients (0000-171)
This study will assess the inter-center reproducibility and accuracy of hepatic fat fraction measurements using up to two MRI-based methods.
- Trial name
- NCT01110577
- Volunteers
- 10 people
- Sponsor
- Merck Sharp & Dohme LLC
Prediabetes
Effect of the Extract of the Flour Fermented With Bacillus Subtilis Var Natto DC-15 on Postprandial Glucose
The purpose of the present study is to evaluate the effect of the extract of the flour fermented with Bacillus subtilis var natto DC-15 on postprandial glucose level in subjects with prediabetes.
- Trial name
- NCT02300181
- Testing
- Bacillus subtilis var natto DC-15
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
PreDiabetes
Effects of Bitter Melon on Cardiometabolic Health
The objectives of this study are to assess the effects of a bitter melon product at two doses, compared to control, on indicators of cardiometabolic health among men and women with prediabetes.
- Trial name
- NCT05540405
- Testing
- Low-dose bitter melon, High-dose bitter melon
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Impaired Glucose Tolerance
ACute and Chronic Effects of Saxagliptin
Glucose ACCES study will explore the acute and long term (12-week treatment) effects of saxagliptin in patients with impaired glucose tolerance during fasting and after a standardised breakfast.
- Trial name
- ACCES (NCT01521312)
- Testing
- saxagliptin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PreDiabetes, Metabolic Syndrome
Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response?
To investigate whether co-administration of lactate with a glucose load affects postprandial glucose levels/handling, gastrointestinal hormones, gastric emptying, and appetite sensations in individuals with pre-diabetes when…
- Conditions
- PreDiabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT06265337
- Testing
- Lactate
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pre-diabetes, Overweight
Fit and Trim for Diabetes Prevention
Filipino Americans (FA) are the second largest (3.4 million) Asian group in the US. and have one of the highest prevalences of obesity and type 2 diabetes mellitus compared to non-Hispanic whites, African Americans and Hispanics.
- Conditions
- Pre-diabetes, Overweight, Obese
- Trial name
- NCT02278939
- Testing
- Filipinos Fit and Trim Weight Loss Program
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Prediabetes
Impact of Saccharin and Acesulfame-Potassium on Glycemia
The major purpose of this research project is to learn if consuming artificial sweeteners have any impact on glucose levels in adults at high risk for developing type 2 diabetes.
- Trial name
- NCT07506577
- Testing
- non-sugar sweetener - saccharin, non-sugar sweetener - acesulfame potassium, non-sugar sweetener - control
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Polytechnic Institute and State University
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2, PreDiabetes
Contrasting Ketogenic and Mediterranean Diets in Individuals With Type 2 Diabetes and Prediabetes: The Keto-Med Trial
The objective of this study is to compare two metabolically distinct diets, WFKD vs Med-Plus, in order to examine the potential benefits, and unintended consequences, of going beyond a focus on maximally avoiding added sugars and…
- Trial name
- NCT03810378
- Testing
- Mediterranean Diet (Med-Plus), Well-Formulated Ketogenic Diet (WFKD)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pre-diabetes
AI-Assisted Blood Glucose Management Study
AI-driven health management tools can leverage continuous glucose monitoring (CGM), physical activity, and dietary data to provide real-time, individualized feedback, improving self-management and adherence.
- Trial name
- NCT07160985
- Testing
- AI-based Lifestyle Management, Lifestyle Management
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Li Huating
Healthy, PreDiabetes
Blood Glucose, Cognition and Wellbeing @ Work
This randomized controlled pilot study has as a main aim to investigate the relationship between glucose and cognition and wellbeing, as well as food intake in an at-work setting.
- Trial name
- NCT03295578
- Testing
- Personalized feedback, Generic feedback, Continuous glucose monitoring device
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TNO
Obesity
Antidiabetic Properties of Rose Hip
The purpose of this study is to determine whether daily intake of a drink containing rose hip powder reduces risk markers of type diabetes and cardiovascular disease.
- Trial name
- NCT01316016
- Testing
- Rose hip
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Lund University
Aging, Cardiovascular Diseases
Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population
Physical inactivity is known to increase post meal blood sugar levels in young, active populations. However, how quickly this may occur in active, older adults is not clear.
- Conditions
- Aging, Cardiovascular Diseases, Glucose Intolerance
- Trial name
- NCT04812392
- Testing
- Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leryn Reynolds
Prediabetes, Vitamin D Deficiency
Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a major public health problem .Prevalence of vitamin D deficiency is also high i.e. 78-96% in different groups of population in north India.
- Trial name
- NCT01436916
- Testing
- oral cholecalciferol + life style counselling
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Prediabetes
Chinese Diabetes Prevention Program (Chinese DPP)
This study is being conducted in two phases. The first phase was a pilot implementation of the study protocol, which provided preliminary data from seeking funding for a larger scale trial.
- Trial name
- NCT02277509
- Testing
- Chinese DPP, Minimal Intervention Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs