Clinical trials: PreDiabetes, completed
Prediabetic State, Non-alcoholic Fatty Liver Disease
ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD
A Phase 2a, randomized, double-blind, placebo-controlled, multi-center study of cenicriviroc (CVC) to be conducted in approximately 50 adult obese subjects [body mass index (BMI) ≥ 30 kg/m^2] with prediabetes or type 2 diabetes…
- Conditions
- Prediabetic State, Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT02330549
- Testing
- Cenicriviroc 150 mg
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 45 people
- Sponsor
- Tobira Therapeutics, Inc.
Myocardial Insulin Sensitivity, Impaired Glucose Metabolism
Ciprofibrate and Pre-diabetes
Free fatty acids (FFA) are the main fuel source in a healthy adult heart, since they are responsible for 70-80% of the myocardial ATP production.
- Conditions
- Myocardial Insulin Sensitivity, Impaired Glucose Metabolism, Diastolic Dysfunction
- Trial name
- FIT (NCT03662984)
- Testing
- Ciprofibrate 100Mg Tablet
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Resistance, HIV Infections
Use of a Nutritional Supplement to Treat Diabetic Symptoms in HIV-Infected Adults
The purpose of this study is to determine the effectiveness of the nutritional supplement chromium picolinate in improving insulin resistance, a symptom of diabetes, in HIV-infected patients.
- Trial name
- NT (NCT00109746)
- Testing
- chromium picolinate
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pre-diabetes
Continuous Glucose Monitoring (CGM) With a Low Carbohydrate Diet to Reduce Weight in Patients With Pre-Diabetes
This study will recruit pre-diabetic patients to see if continuous glucose monitoring (CGM) with a low carbohydrate diet can reduce the percentage of time the CGM readings are above the normal range.
- Trial name
- NCT03695913
- Testing
- Normal Diet, Low carb diet, CGM with no real time feedback
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
PreDiabetes, Obesity, Childhood
Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance
The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of…
- Trial name
- NCT05055219
- Where
- United States
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pre-diabetes, Diabetes
RCT of SMS for Drivers With Pre-DM
The purpose of this study is to prevent the professional drivers from pre-diabetes to diabetes.
- Trial name
- NCT01556880
- Testing
- Short Message Service (SMS)
- Where
- 3 sites in Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
PreDiabetes
The Effects of Hesperidin and Flaxseed in Prediabetes
To study the effects of Hesperidin and flaxseed supplement in patients with prediabetes, 50 patients will be randomly allocated to control group or 2 capsules Hesperidin and 30 gram flaxseed for 12 weeks; both groups will be…
- Trial name
- NCT03737422
- Testing
- hesperidin and flaxseed, control
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- National Nutrition and Food Technology Institute
PreDiabetes
PreDM Clinical Decision Support Intervention
Clinical practice guidelines recommend intensive lifestyle interventions and metformin to prevent or delay type 2 diabetes; yet these treatments are not routinely used among the 86 million U.S.
- Trial name
- PreDM_CDS (NCT04335331)
- Where
- United States
- Volunteers
- 7,424 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Glucose Tolerance Impaired
Dose Response Relationship Between Fat Ingestion and Metabolism
The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity.
- Trial name
- AFDR (NCT05906342)
- Testing
- 20% fat meal, 40% fat meal, 60% fat meal
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Metabolic Syndrome X, Prediabetic State
Chromium Picolinate for the Treatment of Metabolic Syndrome
The purpose of this study is to determine whether chromium supplements can reduce symptoms of metabolic syndrome, a collection of symptoms that increase one's risk for developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Prediabetic State, Insulin Resistance, Obesity
- Trial name
- NCT00128154
- Testing
- Chromium picolinate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Impaired Glucose Tolerance, Obstructive Sleep Apnea
Effects of Treatment of Sleep Apnea on Metabolic Syndrome
The investigators performed a randomized, cross-over controlled clinical trial comparing 8 weeks of Continuous Positive Airway Pressure (CPAP) to 8 weeks of sham-CPAP in patients with moderate to severe Sleep Disordered Breathing…
- Trial name
- NCT01385995
- Testing
- Continuous Positive Airway Pressure (CPAP) (Philips-Respironics RemStar Pro® CPAP)
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Postprandial Glycemia, Postprandial Insulinemia
A Human Clinical Trial Evaluating the Effect of MealShape™ on Blood Glucose Level Following Consumption of Standard Meal
The purpose of the study is to evaluate the effect of MealShape, a Ceylon cinnamon extract (Cinnamomum zeylanicum) on blood glucose and insulin response after consumption of a standard meal composed of white bread, in healthy…
- Trial name
- NCT02074423
- Testing
- MealShape cinnamon extract
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Dialpha
Sleep Disorder, Metabolic Glucose Disorders
Efficiency of a Nursing Intervention in Sleep Hygiene
Background: The relationship between the appearance of insulin resistance phenomena and insufficient or poor-quality sleep is scientifically documented.
- Trial name
- ENISH (NCT03857802)
- Testing
- Sleep hygiene intervention
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Overweight and Obesity, PreDiabetes
Effects of Yogurt With Spirulina on Cardiometabolic Risk Markers
The effects of yogurt with spirulina consumption compared to conventional yogurt (without spirulina) on several cardiometabolic and anthropometric parameters in individuals at risk of cardiovascular disease
- Conditions
- Overweight and Obesity, PreDiabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114563
- Testing
- Spirulina yogurt, Conventional yogurt
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- Agricultural University of Athens
Diabetes, Cardiovascular Diseases
The Effects of Apple Consumption on Cardiovascular Health in Prediabetics and Type 2 Diabetics
The hypothesis of this study is that the daily consumption of 75 g dried apple powder for twelve weeks will improve arterial stiffness and blood pressure by improving endothelial-mediated vasodilation and vascular sympathetic…
- Conditions
- Diabetes, Cardiovascular Diseases, Prediabetes
- Trial name
- NCT02224365
- Testing
- Apple
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida State University
Type 2 Diabetes, Glucose Metabolism Disorders
DEMOJUAN- DEMOnstration Area for Primary Prevention of Type 2 Diabetes, JUAN Mina and Barranquilla, Colombia
The main aim of this study is to investigate to what extent it is possible to reach normal glucose metabolism and optimal cardiovascular disease (CVD) risk factor levels with early lifestyle interventions in people at high risk…
- Trial name
- DEMOJUAN (NCT01296100)
- Testing
- Lifestyle intervention (nutrition), Lifestyle intervention (physical activity)
- Where
- 5 sites in Colombia
- Volunteers
- 730 people
- Sponsor
- Centro de Investigacion Sanitaria
Obesity, Pre-diabetes
SGLT2 Inhibitor Effects on Inflammation and Heart Disease in Obesity Pilot
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue.
- Trial name
- NCT04907214
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Prediabetes
Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes
Prediabetes effects 96 million people 18 years of age or older. It is important to identify treatment options to slow or prevent progression to diabetes.
- Trial name
- PREVNT (NCT06828731)
- Testing
- Empagliflozin 10mg daily, Lifestyle education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Charles George VA Medical Center