Clinical trials: PreDiabetes, completed
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Physical Activity
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program.
- Trial name
- NCT02552355
- Testing
- Metformin, Carbohydrate Beverage, Protein Beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colorado State University
PreDiabetes
Attitudes of General Practitioners in Lorraine Towards Prediabetes
Screening for the risk factors of type 2 diabetes is a part of the primary prevention approach. Pre-diabetes is one of the modifiable risk factors; however, it remains under-diagnosed.
- Trial name
- PréDiabMedG (NCT05473078)
- Testing
- online anonymous exploratory study
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Central Hospital, Nancy, France
PreDiabetes, Prediabetic State
Use of Empagliflozin to Treat Prediabetes
The overall purpose of this study is to identify how empagliflozin (a drug commonly used to treat type 2 diabetes) impacts skeletal muscle metabolic health among adults with prediabetes.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05426525
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Pre-diabetes
Continuous Glucose Monitoring (CGM) With a Low Carbohydrate Diet to Reduce Weight in Patients With Pre-Diabetes
This study will recruit pre-diabetic patients to see if continuous glucose monitoring (CGM) with a low carbohydrate diet can reduce the percentage of time the CGM readings are above the normal range.
- Trial name
- NCT03695913
- Testing
- Normal Diet, Low carb diet, CGM with no real time feedback
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Pre Diabetes, Overweight and Obesity
TRE With Physical Activity for Weight Management
Approximately 24 million older adults have prediabetes. Obesity, age related decreases in lean mass and increases in fat mass, and sedentary lifestyle have been associated with functional and cognitive decline in older adults.
- Trial name
- NCT04978376
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Illinois Chicago
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
Pre-diabetes
Diabetes Prevention Program Pilot
This initiative, which is a partnership between State College area Penn State Health ambulatory care clinics located off campus in the State College area, has two primary goals: 1) improve the health and quality of life of Penn…
- Trial name
- NCT04651816
- Testing
- Financial Incentives, Motivational Message, DPP Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Obesity, Morbid
GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children
The prevalence of severely obese children is on the rise. Behavioral therapies for weight loss are successful in some, but others need more aggressive approaches such as drug therapy.
- Trial name
- NCT00886626
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Prediabetes
Exploring Unconventional Plant-Derived Metabolites for Glycemic Control: the Case of Pomegranate
The EXPLORER study will investigate whether supplementation with a pomegranate extract rich in ellagitannins is able to improve well-being and metabolic health in individuals without diabetes.
- Trial name
- EXPLORER (NCT06659523)
- Testing
- EPS supplement intervention
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regina Menezes
Glucose Intolerance, Obesity
Physiological Effects of Stevia Consumption in Humans
This study will evaluate whether long-term consumption of the low calorie sweetener stevia affects glucose tolerance in healthy participants.
- Trial name
- NCT03993418
- Testing
- stevia
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Prediabetes
Prevention of Type 2 Diabetes With Vitamin D Supplementation
PREVENT-WIN study has three components. The work plan will have the following S\&T components. Component 1: Cross-sectional Study Cross-sectional study will be of 1.5 years where 400 women from rural will be screened randomly for…
- Trial name
- PREVENT-WIN (NCT02513888)
- Testing
- vitamin D + diet and lifestyle
- Where
- India
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabetes, Nutrition Disorders
OPTIFIT-Optimal Fiber Trial for Diabetes Prevention
High intake of insoluble fiber is strongly associated with a reduced incidence of diabetes and cardiovascular events in prospective observation studies.
- Conditions
- Diabetes, Nutrition Disorders, Obesity, Overweight
- Trial name
- NCT01681173
- Testing
- Fiber
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- German Institute of Human Nutrition
Weight Loss, Blood Pressure
Feasibility & Implementation of a Plant-Based Weight-Loss Program in an Office-Based Setting
This prospective study aims to assess the feasibility and implementation of a plant-based, weight-loss program in an office setting.
- Conditions
- Weight Loss, Blood Pressure, Lipid Disorder, PreDiabetes
- Trial name
- NCT04091516
- Testing
- Low-fat plant-based diet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Over Age 60, Prediabetes or Overweight
Curcumin Supplementation for the Improvement of Diabetes-related Outcomes
The goal of this clinical trial is to learn about, test, and compare health outcomes of curcumin supplementation (400 mg). Two primary hypotheses are: 1.
- Trial name
- CUR-T2D (NCT06984640)
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Hypertension
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hypertension.
- Trial name
- MEAD (NCT00887510)
- Testing
- Hydrochlorothiazide, Trandolapril
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Prediabetes
Anti-diabetic Effects of Persimmon Leaf Extract
The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose.
- Trial name
- NCT02706821
- Testing
- Persimmon leaf extract
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Infant Conditions, Glucose Intolerance
Monitoring of Postprandial Glycemic Variability in Healthy Young Infants
To measure and quantify the postprandial glucose variations in response to a meal in the healthy 6-12 months old child and correlate this response with the composition of this meal.
- Trial name
- IGVM (NCT03819725)
- Testing
- Glucose monitoring
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diabetes Mellitus, Type 2
A Study to Determine Acute (After First Dose) and Chronic (After 28 Days) Effects of Empagliflozin (BI 10773) on Pre and Postprandial Glucose Homeostasis in Patients With Impaired Glucose Tolerance and Type 2 Diabetes Mellitus and Healthy Subjects
An open-label, phase II study to assess the acute and chronic effects of empagliflozin (BI 10773)on fasting and postprandial glucose homeostasis in patients with IGT and type 2 diabetes mellitus and assess the acute effects of…
- Trial name
- NCT01248364
- Testing
- BI 10773
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim