Clinical trials: PreDiabetes, completed
Metformin, Prediabetes
Metformin and Molecular Aging in Prediabetes
The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing globally. The global prevalence of diabetes has nearly doubled since 1980, rising from 4.7% to 8.5% in the adult population.
- Trial name
- NCT07302932
- Testing
- Metformin treatment, Analyzed by qPCR for T/S ratio.
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Obesity, Hypertension
Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management
The purpose of this study is to investigate the effect of providing healthy foods and nutrition education on participants' body weight, blood pressure, and average blood sugar level.
- Conditions
- Obesity, Hypertension, Pre-diabetes, Type 2 Diabetes
- Trial name
- NCT05174078
- Testing
- Medically-tailored meals, Produce box and recipes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Cleveland Clinic Akron General
Eating Behavior, Metabolic Syndrome
Study of Eating Patterns With a Smartphone App and the Effects of Time Restricted Feeding in the Metabolic Syndrome
SwissChronoFood - Study of eating patterns with a smartphone app and the metabolic effects of time restricted feeding in metabolic syndrome The purpose of this study is to assess eating patterns among teenagers and adults with a…
- Conditions
- Eating Behavior, Metabolic Syndrome, Obesity, Dyslipidemias
- Trial name
- NCT03241121
- Testing
- Time restricted feeding, Regular dietary advices, Eating patterns
- Where
- 2 sites in Switzerland
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Myocardial Insulin Sensitivity, Impaired Glucose Metabolism
Ciprofibrate and Pre-diabetes
Free fatty acids (FFA) are the main fuel source in a healthy adult heart, since they are responsible for 70-80% of the myocardial ATP production.
- Conditions
- Myocardial Insulin Sensitivity, Impaired Glucose Metabolism, Diastolic Dysfunction
- Trial name
- FIT (NCT03662984)
- Testing
- Ciprofibrate 100Mg Tablet
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Glucose Intolerance
C-reactive Protein and Endothelial Dysfunction in Women With Glucose Intolerance
The goal of this study is to determine whether markers of vascular inflammation (such as c-reactive protein) can predict endothelial dysfunction (as measured by flow-mediated dilation) in postmenopausal women with glucose…
- Trial name
- NCT00589355
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Yale University
Pre Diabetes, Insulin Resistance
Exenatide and Weight Loss for Diabetes Prevention
Exenatide, a GLP-1 agonist approved for lowering blood glucose concentrations in patients with type 2 diabetes, has been associated with restoration of the first-phase insulin response when administered intravenously to patients…
- Trial name
- NCT02084654
- Testing
- Exenatide 5 and 10 mcg 2 times a day
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Disorder, Metabolic Glucose Disorders
Efficiency of a Nursing Intervention in Sleep Hygiene
Background: The relationship between the appearance of insulin resistance phenomena and insufficient or poor-quality sleep is scientifically documented.
- Trial name
- ENISH (NCT03857802)
- Testing
- Sleep hygiene intervention
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Pre-Diabetes
Improving Beta Cell Function in Mexican American Women With Prediabetes
This study will examine the benefits of weight loss alone or in combination with a GLP1 receptor agonist, liraglutide, on beta cell function in young adult Mexican American (MA) women with prediabetes.
- Trial name
- NCT02488057
- Testing
- Liraglutide, Weight loss
- Where
- 4 sites in United States
- Volunteers
- 360 people
- Sponsor
- Ohio State University
Diabetes, Prediabetes
Meta-analyses of the Effect of Tree Nuts on Glycemic Control and Features of the Metabolic Syndrome
Tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamia nuts, pecans, pine nuts, pistachios and walnuts) are an important source of unsaturated fatty acids, vegetable protein, and fibre, as well as minerals, vitamins, and…
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01630980
- Testing
- Tree nuts
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Prediabetic State, Dysglycemia
Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to investigate the effects of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day, on cardiometabolic health and gut microbiota profile in overweight-obese…
- Conditions
- Prediabetic State, Dysglycemia, Overweight and Obesity
- Trial name
- NCT05369585
- Testing
- TOTUM-63
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Obesity, Metabolic Syndrome
Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults
The purpose of the study was to determine the effects of growth hormone and an insulin sensitizer drug in pre-diabetic adults with excessive amounts of abdominal fat.
- Conditions
- Obesity, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT00352287
- Testing
- Recombinant human growth hormone; pioglitazone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Ferritin, Insulin Sensitivity
Blood Donation Could Improve Insulin Sensitivity
Studies in the literature suggest that people with obesity have an excess of stored iron. There is possibly an inverse relationship between ferritin levels and the actions of insulin on glycemic control.
- Conditions
- Ferritin, Insulin Sensitivity, Blood Donation
- Trial name
- GLUCFER (NCT05791968)
- Testing
- Whole blood standard donation
- Where
- Spain
- Volunteers
- 89 people
- Sponsor
- University of Castilla-La Mancha
Overweight, Obesity
Effects of a Wholegrain Diet on Body Composition and Energy Balance
The purpose of this study is to compare a diet containing whole grains versus an energy matched diet using refined grains on body composition and metabolism.
- Conditions
- Overweight, Obesity, Pre-diabetic
- Trial name
- NCT01411540
- Testing
- Whole grains
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Body Composition, Beneficial, Paresis
Meal Patterning on Weight Loss With Changes to Body Comp, Muscle and Metabolic Health
About two-thirds of adults in the United States are overweight or obese with likely adverse health consequences. A Moderate weight loss by dieting and exercise is recommended to improve health.
- Conditions
- Body Composition, Beneficial, Paresis, Impaired Glucose Tolerance
- Trial name
- S38 (NCT02066948)
- Testing
- wt loss, Meal Pattern, even
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Purdue University
Glucose Intolerance, Postprandial Hyperglycemia
Effect of Acarbose on Postprandial Lipoprotein Levels in Glucose Intolerant Patients
Is a randomized, double-blind, placebo-controlled trial to determine the behavior of hyperglycemia and postprandial lipemia after a standard mixed meal load in patients with carbohydrate intolerance treated with acarbose.
- Conditions
- Glucose Intolerance, Postprandial Hyperglycemia, Cardiovascular Risk Factor
- Trial name
- NCT02355509
- Testing
- Acarbose
- Where
- Mexico
- Volunteers
- 21 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Diabetes, Weight Loss
De Por Vida: A Diabetes Risk Reduction Intervention for Hispanic Women
This pragmatic randomized clinical trial will assess the efficacy, cost, and sustainability of a culturally tailored weight-loss program targeting obese Hispanic women with pre-diabetes or T2D.
- Conditions
- Diabetes, Weight Loss, PreDiabetes, Obesity
- Trial name
- NCT03113916
- Testing
- Behavioural Lifestyle Intervention
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Glucose Intolerance
Carnitine Supplementation in Type 2 Diabetic Patients
the results from animal studies and preliminary human studies show that carnitine availability and acetylcarnitine concentrations are low in insulin resistant states such as with type 2 diabetes mellitus.
- Trial name
- NCT03230812
- Testing
- Carnitene (L-Carnitine or Levocarnitine)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Maastricht University Medical Center
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.