Clinical trials: Prebiotic
Blood Glucose Control
A Study to Evaluate the Effects of a Prebiotic Soda on Glycemic Control in Adults
The main objective of this study is to evaluate the chronic effects of replacing traditional non-diet soda with a prebiotic soda on biomarkers associated with glycemic control in adults with glucose dysregulation who are habitual…
- Trial name
- NCT07298135
- Testing
- Prebiotic Soda, Active Control
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Olipop, PBC
PARKINSON DISEASE (Disorder)
Open Label Single Arm Prebiotic Pilot Trial SR001
The goal of this pilot clinical study is to evaluate the effect of a prebiotic fiber blend in individuals diagnosed with Parkinson's Disease. The main objectives of this pilot study are: 1.
- Trial name
- NCT07127120
- Testing
- Prebiotic fiber blend
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sorridi Therapeutics
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Healthy Infants
Study on the Effect of Inulin in Infant Formula on Gut Health
In this study the effect of Infant formula with added Inulin will be compared with the effect of Infant formula without Inulin on the Bifidobacterium level in stool.
- Trial name
- STAR-IFFO (NCT01515644)
- Testing
- Powder based infant formula
- Where
- Indonesia
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- PT. Sari Husada
Sensory Perceptual Characteristics, User Acceptability of Gel Delivery System
Perception & Acceptability of a Cervical Cancer Prevention Prebiotic Device
PreBioGyn will be compared to market leading vaginal pH buffering gels using established forearm test methods associated with vaginal lubricity sensation in 42 women.
- Trial name
- NCT04841629
- Testing
- PreBioGyn Gel, Trimosan Gel, RepHresh Gel
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Glyciome, LLC
Healthy
Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans
The aim of the study is to investigate whether the food matrix has an influence on the prebiotic efficacy (bifidobacteria growth) of chicory-derived Orafti® inulin in healthy adult volunteers.
- Trial name
- NCT05581615
- Testing
- Inulin
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Digestion, Happiness
Parental Notions and Clinical Experiences About Child's Gut Comfort, Overall Satisfaction and Sense of Well-being When Consuming a New Toddler Milk
This is a prospective, open-label, single-arm study in a real-world setting of healthy Chinese toddlers provided with new toddler milk for a total of 4 weeks (28 days).
- Conditions
- Digestion, Happiness, Temperament
- Trial name
- NCT04768933
- Testing
- Toddler Milk
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Infant Term Birth
Safety and Efficacy Study
The purpose of this study is to evaluate the safety and efficacy of the experimental formula supplemented with a prebiotic vs the control formula.
- Trial name
- NCT02670863
- Testing
- Experimental Infant Formula, Standard Infant Formula
- Where
- Philippines
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Study to Evaluate the Tolerability of Prebiotics on the Microbiota
The primary objective of this study is to determine the tolerability of two polyglycan food ingredients, GOS and GLOS, at two different levels in healthy human subjects.
- Trial name
- NCT02628652
- Testing
- GOS, GLOS, FOS
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kaleido Biosciences
Mood
Effects of Prebiotics on Intestinal Colonization and Mood in a University Cohort
There is a growing interest within the scientific community of whether prebiotics can aid in clinical outcomes including mood via modulation of the gut microbiota and its resulting metabolites via the gut-brain axis.
- Trial name
- NCT05212545
- Testing
- Prebiotic supplement, Prebiotic combination, Prebiotic oligosaccharides
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Gastrointestinal Function
Effect of MSPrebiotic on Gastrointestinal Function and Blood Glucose Levels
The objective of the study is to investigate the impact of daily consumption of MSPrebiotic at a dosage level of 30 g per day for 12 weeks on gastrointestinal microbiota in the elderly (> 70 years age) and another age group (30…
- Trial name
- NCT03910153
- Testing
- MSPrebiotic
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- MSP Starch Products Inc.
Stress, Healthy Subjects
The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety
Emerging evidence from preclinical research suggests that prebiotic fibres may play a beneficial role in supporting mental health through modulation of the gut-brain axis-a complex communication network linking the…
- Conditions
- Stress, Healthy Subjects, Anxiety, Mild to Moderate
- Trial name
- PRIME (NCT07058324)
- Testing
- Prebiotic fiber
- Where
- Germany
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Infant Nutrition
Effects of a Synbiotics-containing Starter Formula on Infant Growth
In this study the investigators want to evaluate the satiety of two infant formulas, one containing prebiotics and the other containing synbiotics.
- Trial name
- NCT01010113
- Testing
- Standard infant formula with prebiotics, Infant formula with synbiotics
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Urea Cycle Disorders
Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders
This clinical food study aims to explore the effect of KB195, a novel mixture of oligosaccharides, on the metabolism of nitrogen by the microbiome in patients with urea cycle disorders (UCDs).
- Trial name
- NCT03797131
- Testing
- KB195 (a novel mixture of oligosaccharides)
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Kaleido Biosciences
Stress, Psychological
Prebiotics and Stress Reduction in Women
In modern life, many people state to experience stress. Women compared to men report more and higher levels of stress. Recent research found that supplementation of galactose-oligosaccharides (GOS) resulted in reduced anxiety…
- Trial name
- NCT05372601
- Testing
- Relax+, Maltodextrin
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina
Child Development, Diet, Healthy
Prebiotic Effects in Healthy Toddlers
The aim of this study is to demonstrate that a dietary supplementation with a novel prebiotic combination is safe, well tolerated and able to improve overall health of toddlers.
- Trial name
- PrebiKidz (NCT05783141)
- Testing
- New prebiotic follow-on formula, randomly assigned to healthy toddlers, Standard follow-on formula, randomly assigned to healthy toddlers
- Where
- Belgium
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Constipation-predominant IBS (IBS-C)
Use of Novel Prebiotic Fiber for Targeted Dietary Management of Irritable Bowel Syndrome (Nutrabiotix Phase II)
The objective of this Phase II trial is to test the NTX-1 Fiber in patients with constipation-predominant IBS (IBS-C) and determine if it can reduce symptoms, beneficially modify gut microbiota composition, and improve gut milieu…
- Trial name
- NCT02144753
- Testing
- NTX-1, psyllium (15 g)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nutrabiotix, LLC
GI Health, Microbial Composition
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greater number and diversity of non-beneficial…
- Trial name
- NCT02743195
- Testing
- Polyphenol/prebiotic blend
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Healthy
Growth of Infants Fed a New Term Infant Formula
To evaluate the growth of healthy term infants fed an experimental infant formula with a prebiotic, a commercial control infant formula with a probiotic, but without a prebiotic and human breast milk
- Trial name
- NCT03090360
- Testing
- Infant formula (CF), Infant Formula (EF)
- Where
- 7 sites in Belgium, Italy
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy Adult Participants, Gut Microbiomes
DORA - A Study Using Digital Health Tools/Platform to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals
The DORA study is a single-arm, open-label, interventional exploratory study designed to evaluate the impact of a synbiotic-containing senior milk powder on the gut microbiome and selected biological, physiological, and digital…
- Conditions
- Healthy Adult Participants, Gut Microbiomes, AI
- Trial name
- DORA (NCT07575529)
- Testing
- Synbiotic Nutritional Product
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.