Clinical trials: Precancerous Condition
Cervical Cancer
SUCCESS - Feasibility of HPV Testing and Treatment of Pre-cancerous Cervical Cancer Lesions (HPV Study)
The goal is to assess the feasibility and acceptability of integrating into existing health systems, provision of HPV screening and treatment of pre-cancerous cervical cancer lesions with ablative treatments in Burkina Faso, Côte…
- Trial name
- HPV (NCT05133661)
- Testing
- HPV testing
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire and 2 more
- Volunteers
- 17,602 people, healthy volunteers welcome
- Sponsor
- Jhpiego
Intestinal Metaplasia of Gastric Mucosa, Gastric Dysplasia
Novel Approach to Surveillance of Gastric Lesions
This will be a pilot study investigating the feasibility of using pressurized irrigation of the stomach mucosa to obtain gastric aspirate cell samples for analysis and identification of premalignant lesions of the stomach.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Gastric Dysplasia, Gastric Cancer, Atrophic Gastritis
- Trial name
- NCT04251403
- Testing
- Mucosal Irrigation
- Volunteers
- 10 people
- Sponsor
- New York Presbyterian Hospital
Cervical Cancer, DNA Methylation
Cervical Cytology DNA Methylation for Cervical Cancer Screening
Cervical cancer represents one of the foremost causes of cancer-related morbidity and mortality among women worldwide. Given the current limitations, such as the low specificity of human papillomavirus (HPV) testing and the…
- Conditions
- Cervical Cancer, DNA Methylation, Cytology, Human Papillomavirus Infection
- Trial name
- NCT06557954
- Testing
- human PAX1 and JAM3 gene methylation assays (PAX1m/JAM3m)
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Lei Li
Barrett's Esophagus
A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy
The primary objective of this study is to determine the percentage segment regression after spray cryotherapy in a dose-escalation study performed in patients with dysplastic Barrett's Esophagus (BE) using trūFreeze™ spray…
- Trial name
- DOSE (NCT01845454)
- Testing
- trūFreeze™ Spray Cryotherapy
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- CSA Medical, Inc.
Barrett's Oesophagus
The Use of Biomarkers to Guide Management of Patients Treated With Radiofrequency Ablation for Early Oesophageal Neoplasia
This prospective cohort study aims to assess the utility of a panel of molecular biomarkers for predicting the risk of relapse of Barrett's Oesophagus after endoscopic treatment of early oesophageal neoplasia with RadioFrequency…
- Trial name
- PROBAN (NCT04155242)
- Testing
- Cytosponge test, Assessment of the panel of molecular biomarkers: IM-SCORE, TFF3 protein expression, methylation panel, p53 mutation, Oesophagogastroduodenoscopy
- Where
- United Kingdom
- Volunteers
- 147 people
- Sponsor
- University of Cambridge
Actinic Keratosis
Cellular and Molecular Events During Treatment of Actinic Keratosis With Imiquimod 5% Cream
Treatment of actinic keratosis with imiquimod cream is expected to cause changes in the genes that are turned on, and turned off, by skin cells.
- Trial name
- NCT00335179
- Testing
- Aldara (imiquimod 5% cream), Vehicle cream
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Graceway Pharmaceuticals, LLC
Actinic Keratoses
Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis
This Phase I study is designed to evaluate the systemic exposure and safety of KX2-391 Ointment in adult subjects when applied to an area of skin containing at least 5 clinically typical, visible, and discrete Actinic Keratosis…
- Trial name
- NCT03575780
- Testing
- KX2-391 Ointment 1%
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Athenex, Inc.
Lung Cancer, Precancerous Condition
Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease
RATIONALE: Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This randomized clinical trial is studying screening tests or exams to see how well they work compared to…
- Trial name
- NCT00512746
- Testing
- cytology and cytometry specimen collection procedure, Chest x ray, Autofluorescence bronchoscopy
- Where
- 10 sites in United Kingdom
- Volunteers
- 1,569 people
- Sponsor
- University College, London
Actinic Keratosis
Observational Trial Tolerability and Efficacy of Resiquimod Gel in Patients Treated for Actinic Keratosis.
Determine the recurrence rate of actinic keratosis (AK) lesions in patients with complete clinical clearance at the end of the previous trial SP848-AK-1101 at 6 and 12 months of follow-up.
- Trial name
- NCT01806961
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 16 people
- Sponsor
- Spirig Pharma Ltd.
Actinic Keratosis
Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis
Actinic keratosis (AKs) are premalignant disorders that can evolve into skin cancer. To prevent their development, a study is being conducted with oral isotretinoin and topical tretinoin to verify what drug is the most effective…
- Trial name
- ARISOAK (NCT02278861)
- Testing
- Oral isotretinoin, Tretinoin 0,05% cream, Sunscreen FPS 60
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Goias
Actinic Keratoses
Study to Evaluate the Safety of BF-200 ALA (Ameluz®) for Photodynamic Therapy (PDT) in the Treatment of Expanded Fields of Actinic Keratosis (AK)
The aim of this study is to assess the pharmacokinetics (PK) of the parent drug 5-aminolevulinic acid (ALA) and its active metabolite protoporphyrin IX (PpIX) during photodynamic therapy with 3 tubes of BF-200 ALA 10% gel…
- Trial name
- NCT04319159
- Testing
- BF-200 ALA and red light LED lamp
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Biofrontera Bioscience GmbH
Gastric Lesion, Gastric Precancerous Condition
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer
The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control…
- Conditions
- Gastric Lesion, Gastric Precancerous Condition, Gastric Cancer
- Trial name
- PREGASIGN#1 (NCT05854368)
- Testing
- Additional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care., Blood collection
- Where
- 8 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Barrett Esophagus, Esophageal Adenocarcinoma
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This randomized phase II trial studies the safety of and how well aspirin works in preventing Barrett's esophagus from returning after it has been successfully eliminated by radiofrequency ablation.
- Trial name
- NCT02521285
- Testing
- Aspirin, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 10 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia
12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004058
- Testing
- tetradecanoylphorbol acetate
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Submucosal Esophageal Adenocarcinoma, Barrett Esophagus
Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma
Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or…
- Conditions
- Submucosal Esophageal Adenocarcinoma, Barrett Esophagus, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- PREFER (NCT03222635)
- Testing
- Endoscopic follow-up
- Where
- 20 sites in Australia, Belgium and 4 more
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC
Infection, Precancerous Condition
Human Papillomavirus Vaccine Therapy in Treating Men With HIV-1 Infection
RATIONALE: Vaccines made from human papillomavirus may help the body build an effective immune response to kill HIV cells. PURPOSE: This phase II trial is studying the side effects and how well human papillomavirus vaccine…
- Trial name
- NCT00513526
- Testing
- Gardasil
- Where
- 8 sites in United States
- Volunteers
- 112 people
- Sponsor
- AIDS Malignancy Consortium
Actinic Keratoses
Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Hands
Interventional, monocentric, national, internal placebo-controlled, prospective pilot study, consisting of two parts, A (single-blinded) and B (open) to assess Efficacy of Tirbanibulin for the treatment of AK on the back of the…
- Trial name
- NCT06026358
- Testing
- Tirbanibulin
- Sponsor
- Medical University of Graz
Actinic Keratoses
PDT vs Peels for Treatment of Actinic Keratoses
The purpose of this study is to to compare photodynamic therapy (PDT) versus the combination of Jessner's solution and 35% trichloroacetic acid (TCA) chemical peels for the treatment of actinic keratoses on upper extremities.
- Trial name
- NCT04429308
- Testing
- Photodynamic Therapy, Chemical Peels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lung Cancer, Precancerous Condition
Natural History of Lung Nodules Seen on CT Scans From Participants at High-Risk of Developing Lung Cancer
RATIONALE: Comparing lung CT scans from participants with lung nodules at high-risk for lung cancer may help doctors learn more about the disease and find better methods of treatment.
- Trial name
- NCT01540552
- Testing
- medical chart review, computed tomography, computer-aided detection/diagnosis
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Precancerous Condition
Omega-3 Fatty Acids in Treating Women With Newly Diagnosed Ductal Carcinoma In Situ and/or Atypical Ductal Hyperplasia
RATIONALE: Polyunsaturated fatty acids are important for normal growth and development. One type, called omega-3 fatty acids (found in fish, fish oil, and some other foods), may affect the growth of abnormal breast cells.
- Trial name
- NCT00627276
- Testing
- omega-3 fatty acid
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- OHSU Knight Cancer Institute