Clinical trials: Precancerous Condition
Periampullary Tumor, Common Bile Duct Neoplasms
Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy
The primary objective of this study is to assess the safety, tolerability and toxicity of preoperative HBOT in patients undergoing a pancreaticoduodenal resection for premalignant and malignant tumors of the common bile duct…
- Conditions
- Periampullary Tumor, Common Bile Duct Neoplasms, Duodenal Neoplasms
- Trial name
- HBOT (NCT02575014)
- Testing
- Preoperative hyperbaric oxygen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida Hospital Tampa Bay Division
Clonal Hematopoiesis of Indeterminate Potential, Monoclonal Gammopathy
Pre-malignant States to Hematologic Malignancies in Firefighters
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic…
- Conditions
- Clonal Hematopoiesis of Indeterminate Potential, Monoclonal Gammopathy, Non Hodgkin Lymphoma, Leukemia
- Trial name
- NCT06870760
- Testing
- Monoclonal Gammopathy, Complete Blood Count with differential (CBC w/ diff), Clonal hematopoiesis (CHIP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Skin Cancer, Non-melanoma Skin Cancer
DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients
This is a pilot, phase 2, prospective, comparative study to evaluate the safety and efficacy of the combination of Levulan® Kerastick® for Topical Solution and blue light illumination using the BLU-U® Blue Light Photodynamic…
- Conditions
- Skin Cancer, Non-melanoma Skin Cancer, Sun Damaged Skin, Actinic Keratosis
- Trial name
- NCT03110159
- Testing
- Levulan® Kerastick®, BLU-U Blue Light Photodynamic Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical Dermatology Specialists
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Actinic Keratoses
Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times
This is an investigator initiated, two center, randomized, evaluator-blinded, bilateral (right vs. left) study of photodynamic therapy in subjects with facial actinic keratoses.
- Trial name
- NCT02622594
- Testing
- Aminolevulinic Acid (ALA), Environ Cosmetic Roller, BLU-U IIlluminator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dermatology, Laser & Vein Specialists of the Carolinas
Chronic Myeloproliferative Disorders, Leukemia
Monoclonal Antibody Therapy in Treating Patients With Advanced Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003082
- Testing
- monoclonal antibody A27.15, monoclonal antibody E2.3
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Arizona
Barrett's Esophagus
Patient Registry: Radio Frequency Ablation of Barrett's Esophagus Using HALO System
The purpose of this study is to provide a tool for physicians to compare outcome data related to the use of the HALO Ablation Systems.
- Trial name
- HALO (NCT02033070)
- Where
- United States
- Sponsor
- Ochsner Health System
Myelodysplastic Syndromes
Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome
This study will investigate the effects of sertraline in people with low-risk myelodysplastic syndrome (MDS). It is hoped that sertraline will decrease disease progression and reduce the need for blood transfusions.
- Trial name
- SS1 (NCT02452983)
- Testing
- Sertraline, Bone Marrow Aspirate/Biopsy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Gustavo Rivero
Actinic Keratoses
A Randomized Multicenter Study of Daylight Mediated Photodynamic Therapy (PDT)
A randomised, multi-center study of daylight mediated photodynamic therapy (PDT) with Metvix in patients with multiple actinic keratosis on the face and/or scalp.
- Trial name
- NCT00711178
- Testing
- Photodynamic therapy with methyl aminolevulinate
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Bispebjerg Hospital
Keratosis
Study to Determine the Maximum Tolerated Dose and Safety of PEP005 Topical Gel
The purpose of this study is : To determine the maximum tolerated dose (MTD) for PEP005 Topical Gel in patients with actinic keratoses.
- Trial name
- NCT00239135
- Testing
- PEP005
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Peplin
Monoclonal Gammopathy of Uncertain Significance, Smoldering Myeloma
Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers
A prospective, pilot study to assess the impact of a 12-month multi-focal lifestyle intervention on myeloma-relevant biomarkers in patients with MGUS or SM.
- Trial name
- NCT06987708
- Testing
- The Multimodal Lifestyle Intervention
- Volunteers
- 67 people
- Sponsor
- Hackensack Meridian Health
Cervical Cancer, Diarrhea
Low-Residue Diet in Treating Diarrhea in Patients Receiving Pelvic Radiation Therapy.
RATIONALE: Eating a diet low in residue (fiber, fat, and certain milk or vegetable products) may help prevent or reduce diarrhea caused by pelvic radiation therapy.
- Conditions
- Cervical Cancer, Diarrhea, Prostate Cancer, Radiation Toxicity
- Trial name
- NCT00258401
- Testing
- dietary intervention, management of therapy complications, quality-of-life assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Cancer, Precancerous Condition
Photodynamic Therapy in Treating Patients With Premalignant or Early Stage Head and Neck Tumors
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed.
- Trial name
- NCT00978081
- Testing
- aminolevulinic acid hydrochloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Barrett Esophagus
Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus
Radiofrequency ablation (RFA) is a mainstay of treatment for patients who have Barrett's esophagus (BE) with dysplasia. For unclear reasons, Barrett's esophagus recurs after successful RFA treatment in approximately 1/3 of…
- Trial name
- NCT02688114
- Testing
- Baseline surveillance endoscopy, Radiofrequency ablation, Follow up endoscopy 1
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Dallas VA Medical Center
Barrett Esophagus, Esophageal Adenocarcinoma
Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus
This study compares patients' acceptability and safety of two established endoscopic methods for treating dysplastic Barrett's esophagus: radiofrequency ablation versus hybrid argon plasma coagulation.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Reflux Disease
- Trial name
- RATE (NCT05051475)
- Testing
- Endoscopic radiofrequency ablation, Endoscopic hybrid argon plasma coagulation
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Centre of Postgraduate Medical Education
CIN - Cervical Intraepithelial Neoplasia, HPV
Multiple Human Papillomavirus Infections in the Development of CIN
Multiple infections of high-risk genotypes of Human Papillomavirus (HR-HPV) in patients with abnormal cervical cytological or histological findings are detectable in a percentage ranging from 20% to 50% of cases.
- Conditions
- CIN - Cervical Intraepithelial Neoplasia, HPV, HPV Vaccines
- Trial name
- HPV dysplasia (NCT06862102)
- Testing
- HPV vaccine
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cervical Intraepithelial Neoplasia
An Assessment of an Attenuated Live Listeria Vaccine in CIN 2+
Cervical cancer is associated with Human Papilloma Virus. About 57% of cervical cancer is the result of infection by Human Papilloma Virus strain 16 (HPV-16). HPV is a very common virus that can affect the cells of the cervix.
- Trial name
- ADXS11-001 (NCT01116245)
- Testing
- ADXS11-001 (Lm-LLO-E7)
- Where
- 15 sites in United States
- Volunteers
- 81 people
- Sponsor
- Advaxis, Inc.
Actinic Keratosis
Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses
The goal of this clinical trial is to see if shorter Photodynamic Therapy (PDT) treatment times will still be effective at treating actinic keratoses (AK) while reducing or eliminating the pain that patients sometimes experience…
- Trial name
- NCT06027619
- Testing
- Topical aminolevulinate (10% ALA gel), Red light illumination
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Atrophic Gastritis
Objective Study on Tongue Diagnosis of Chronic Atrophic Gastritis
Chronic atrophic gastritis with intestinal metaplasia or dysplasia is called precancerous lesions of gastric cancer ( PLGC ). It is an important stage in the transformation of normal mucosa to gastric cancer and is significantly…
- Trial name
- NCT06489132
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Precancerous Conditions, Oral Cancer
Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions
45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals.
- Trial name
- NCT02323672
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University